Neuron-protective composition comprising cassia obtusifolia shoot-derived naphthopyrone derivative
A technology of naphthopyrone and nerve cells, which is applied in the direction of nervous system cells, sugar derivatives, sugar derivatives, etc., can solve problems such as anti-oxidation technology that has not been understood, and achieve protection from oxidative stress, relieve stress, Effects of improving memory and learning ability
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Embodiment 1
[0140] [Example 1] Production of Cassia Seed Bud Extract
[0141] Purchase unsterilized domestic cassia seeds (Cassia obtusifolia L.) ((strain) handsherb, January 2016), and use 20mg / mL concentration of bleaching powder (CaOCl 2 ) after disinfection for 15 minutes, fully washed with water, soaked in pure water for 4 hours, and cultivated under shading conditions for 6 days. The cassia seed buds obtained by the above-mentioned cultivation were dried in 32° C. hot air (38° C.) for 22 days, and ground to obtain 698.4 g of dried plants. Then, after the above-mentioned dried plants were put into an extraction container, after adding 5.5 L of ethanol, they were mixed and stirred at room temperature, and extracted for 7 days. A glass funnel with a diameter of 30 cm was used for gravity filtration, and this process was repeated twice ("extraction-filtration" twice) to obtain a filtered extract. The above-mentioned filtered extract was put into a vacuum concentrator, and under reduce...
Embodiment 2
[0144] [Example 2] Production of cassia seed bud extract cultivated under various light conditions
[0145] In order to compare and analyze the components of the cassia seed bud extract (STS) cultivated under light-shading conditions in the above-mentioned Example 1 and the components of the cassia seed bud extract cultivated under specific light conditions, different wavelength conditions of light were used to cultivate cassia seed bud. Cassiae buds are cultivated by the same method as in the above-mentioned Example 1, and the light conditions when cultivating cassia buds are not light-shielding conditions, irradiating fluorescent lamps, LEDs 385nm, 465nm, 645nm, and 780nm respectively as light of a large number of selective light qualities of wavelengths , each cultivated for 6 days. Using the five kinds of buds obtained through the above-mentioned cultivation, respective cassia seed bud extracts were produced by the same method as in the above-mentioned Example 1, and the ...
Embodiment 3
[0146] [Example 3] Production of fractions of cassia seed bud extract (STS)
[0147] After suspending 66.7 g of the cassia seed bud extract (STS) of the above-mentioned Example 1 in 600 mL of water, 1.8 L of ethyl acetate was added, shaken and stirred at room temperature, and fractional distillation was carried out 4 times every 2 hours to obtain 23.5 g of ethyl acetate fraction (STS-EA). Use dichloromethane (or ethyl acetate) alone for the above-mentioned ethyl acetate fractionation or use a mixed solvent (n-hexane : The mixing ratio (volume ratio) of dichloromethane is 1:1, and the mixing ratio (volume ratio) of dichloromethane:methanol is 200:1, 50:1, 10:1, 5:1, 3:1 and 1 : 1) As a fractionation solvent, a fraction of the above STS-EA, that is, a fraction of cassia seed bud extract (STS) was produced.
[0148] Specifically, the above-mentioned ethyl acetate fraction (STS-EA) was contacted with the above-mentioned 8 kinds of fractionation solvents, stirred in diatomaceous ...
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