Pharmaceutical composition, compound preparation and preparation method and application thereof

A technology of compound preparations and compositions, applied in the field of medicine, can solve the problems of large side effects, unsatisfactory therapeutic effects, slow onset of effects, etc., achieve convenience in taking medicine, inhibit 5-HT and/or NE reuptake, and relieve depression Effect
CN112999350APending Publication Date: 2021-06-22北京斯利安药业有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
北京斯利安药业有限公司
Publication Date
2021-06-22

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Abstract

The invention discloses a pharmaceutical composition, a compound preparation as well as a preparation method and application of the pharmaceutical composition. The pharmaceutical composition comprises the following components in any ratio: a component A: at least one of dextromethorphan or pharmaceutically acceptable salts of dextromethorphan; a component B: at least one of bupropion or medicinal salt of bupropion; component C: at least one of folic acid or folic acid derivatives; and a component D: at least one of methyl donors. The mass ratio of the component A to the component B to the component C to the component D is (1-100):(1-150):(0.1-100):(5-1000). All the components of the pharmaceutical composition can generate a synergistic effect, and the pharmaceutical composition can effectively inhibit over-activation of an NMDA receptor, inhibit reuptake of 5-HT and / or NE and effectively relieve depression.
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Description

technical field

[0001] The application relates to a pharmaceutical composition, a compound preparation and a preparation method and application thereof, which belong to the field of medicine. Background technique

[0002] The common clinical symptoms of depression are apathy, slow thinking, slow movement, etc., lack of interest in anything, loss of confidence in life, lack of sufficient sense of self-identity, and most patients have thoughts of world-weariness and suicide [Meng Pan, Wang Yuhong, Zhang Xiuli, et al. Research progress on the neuroplasticity mechanism of the brain hippocampus in depression [J]. World Journal of Integrative Medicine, 2012, 07(10):914-917]. It is reported that more than 90 million people in China alone suffer from different degrees of depression Depression, this disease seriously affects the physical and mental health of human beings.

[0003] Genetic factors and external environment are important factors affecting the onset of depression; life ...

Claims

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