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Pharmaceutical composition, compound preparation and preparation method and application thereof

A technology of compound preparations and compositions, applied in the field of medicine, can solve the problems of large side effects, unsatisfactory therapeutic effects, slow onset of effects, etc., achieve convenience in taking medicine, inhibit 5-HT and/or NE reuptake, and relieve depression Effect

Pending Publication Date: 2021-06-22
北京斯利安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since the 1950s, a variety of drugs for the treatment of depression have been developed, mainly based on the monoamine neurotransmitter hypothesis and targeting monoamine neurotransmitters or their receptors, which can be divided into 8 categories: Monoamine oxidase inhibitors (MAOIs), tricyclics (TCAs), selective serotonin reuptake inhibitors (SSRIs), 5-HT2A receptor antagonists and serotonin reuptake inhibitors (SARIs), NE / DA uptake Inhibitors (NDRIs), NE and specific 5-HT antidepressants (NaSSAs), NE reuptake inhibitors (NaRIs), 5HT and NE reuptake inhibitors (SNRIs), the above types of drugs have unsatisfactory therapeutic effects, Disadvantages such as slow onset of action and large side effects

Method used

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  • Pharmaceutical composition, compound preparation and preparation method and application thereof
  • Pharmaceutical composition, compound preparation and preparation method and application thereof
  • Pharmaceutical composition, compound preparation and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0140] The preparation of embodiment 1 compound tablet

[0141] The prescription is as follows (1000 tablets):

[0142]

[0143] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and set aside. Take by weighing dextromethorphan 15g, bupropion 30g, betaine 300g, carboxymethyl starch sodium 20g, calcium hydrogen phosphate 180g and evenly mix to form a mixture, and folic acid is dissolved in 200ml of 10% povidone aqueous solution (folic acid can dissolve completely That is, the amount of 10% povidone aqueous solution should not be too much), mix with the above-mentioned mixed material, then add the remaining 10% povidone aqueous solution, make soft material, 30 mesh granulation, add 5g magnesium stearate, mix , Determination of content, tableting, that is. During the preparation procedure, pay attention to avoid light. After the finished product passes the inspection, it will be packaged in aluminum and plastic. Keep away from light. Each...

Embodiment 12

[0151] Embodiment 12 prepares compound capsule

[0152] The prescription is as follows (1000 capsules):

[0153]

[0154] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and set aside. Take by weighing 50g of dextromethorphan, 100g of bupropion, 300g of betaine, 150g of lactose, 20g of sodium starch glycolate and evenly mix to form a mixture, and dissolve folic acid in 200ml of 10% povidone aqueous solution (folic acid can be completely dissolved). , the amount of 10% povidone aqueous solution should not be too much), mixed with the above-mentioned mixed materials, and then added the remaining 10% povidone aqueous solution to make soft materials, granulated with 30 mesh, dried at 60 ° C for 3 hours; granulated with 20 mesh, moisture Control it within 2.0%, add magnesium stearate in the prescribed amount, mix well, measure the content, pack into capsules, and get final product. During the preparation procedure, pay attention to avoid lig...

Embodiment 13～22

[0155] Embodiment 13~22 prepares compound capsule

[0156] The preparation process is the same as in Example 12. The composition and content of the 10 kinds of compound capsules are shown in Table 1, and the types and dosages of the 10 kinds of compound capsules are shown in Table 3.

[0157] Table 3 Types and dosages of excipients of 10 kinds of compound capsules.

[0158]

[0159]

[0160] Note: Adjust the dosage of 10% povidone according to the temperature and humidity, so that the soft material is suitable for the granulator.

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PUM

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Abstract

The invention discloses a pharmaceutical composition, a compound preparation as well as a preparation method and application of the pharmaceutical composition. The pharmaceutical composition comprises the following components in any ratio: a component A: at least one of dextromethorphan or pharmaceutically acceptable salts of dextromethorphan; a component B: at least one of bupropion or medicinal salt of bupropion; component C: at least one of folic acid or folic acid derivatives; and a component D: at least one of methyl donors. The mass ratio of the component A to the component B to the component C to the component D is (1-100):(1-150):(0.1-100):(5-1000). All the components of the pharmaceutical composition can generate a synergistic effect, and the pharmaceutical composition can effectively inhibit over-activation of an NMDA receptor, inhibit reuptake of 5-HT and / or NE and effectively relieve depression.

Description

technical field [0001] The application relates to a pharmaceutical composition, a compound preparation and a preparation method and application thereof, which belong to the field of medicine. Background technique [0002] The common clinical symptoms of depression are apathy, slow thinking, slow movement, etc., lack of interest in anything, loss of confidence in life, lack of sufficient sense of self-identity, and most patients have thoughts of world-weariness and suicide [Meng Pan, Wang Yuhong, Zhang Xiuli, et al. Research progress on the neuroplasticity mechanism of the brain hippocampus in depression [J]. World Journal of Integrative Medicine, 2012, 07(10):914-917]. It is reported that more than 90 million people in China alone suffer from different degrees of depression Depression, this disease seriously affects the physical and mental health of human beings. [0003] Genetic factors and external environment are important factors affecting the onset of depression; life ...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/485A61K31/137A61K31/519A61K31/205A61K31/7076A61K9/20A61K9/48A61K9/16A61P25/24
CPCA61K45/06A61K31/485A61K31/137A61K31/519A61K31/205A61K31/7076A61K9/2059A61K9/4866A61K9/1652A61P25/24
Inventor 郑莎张书彬杨卓理易斌韩雅慧钟敏张蕾岳玉荣
Owner 北京斯利安药业有限公司
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