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A nanoporous graphene/nitrocellulose membrane for antibacterial and wound healing promotion and preparation method thereof

A nitrocellulose membrane and nitrocellulose technology, applied in the direction of resisting vector-borne diseases, bandages, absorbent pads, etc., can solve the problems that cannot effectively improve the gas-permeable wound healing of nitrocellulose membrane, and achieve the promotion of wound healing Effects of healing, broad-spectrum antimicrobial properties, good toughness and biocompatibility

Active Publication Date: 2022-05-17
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its strong π-π conjugation, graphene oxide is easy to stack and agglomerate in solution, so it still cannot effectively improve the gas permeability of nitrocellulose membranes and promote rapid wound healing.

Method used

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  • A nanoporous graphene/nitrocellulose membrane for antibacterial and wound healing promotion and preparation method thereof
  • A nanoporous graphene/nitrocellulose membrane for antibacterial and wound healing promotion and preparation method thereof
  • A nanoporous graphene/nitrocellulose membrane for antibacterial and wound healing promotion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Mix the graphene oxide dispersion with the zinc nitrate solution so that the final concentration of the former is 4 g / L, and the final concentration of the latter is 800 g / L, stir and mix evenly, the mixed solution is filtered with filter paper, and then the filter paper and The intercepted mixture was dried in an oven at 55°C, then ignited in an alcohol lamp and fully incinerated. The incineration product was repeatedly washed with 10% hydrochloric acid, then washed with distilled water until the pH was neutral, and the nanoporous graphene was collected by centrifugation;

[0026] (2) Take 0.003 g of nanoporous graphene prepared in step (1), add it to 250 μL ethanol, and add 750 μL nitrocellulose solution (collodion; content: w / % 4-8%) after ultrasonic dispersion, Continue to sonicate and mix evenly to obtain a mixed solution;

[0027] (3) The mixed solution prepared in step (2) was added dropwise to a 35 mL petri dish, and air-dried to form a film to obtain a nan...

Embodiment 2

[0029] (1) Mix the graphene oxide dispersion with the zinc nitrate solution so that the final concentration of the former is 6 g / L, and the latter is 800 g / L, stir and mix evenly, the mixed solution is filtered with filter paper, and then the filter paper and The intercepted mixture was dried in an oven at 55°C, then ignited in an alcohol lamp and fully incinerated. The incineration product was repeatedly washed with 10% hydrochloric acid, then washed with distilled water until the pH was neutral, and the nanoporous graphene was collected by centrifugation;

[0030] (2) Take 0.001 g of nanoporous graphene prepared in step (1), add it to 250 μL ethanol, and after ultrasonic dispersion, add 750 μL nitrocellulose solution (collodion; content: w / %4-8%) to continue Ultrasound and mix uniformly to obtain a mixed solution;

[0031] (3) The mixed solution prepared in step (2) was added dropwise to a 35mL petri dish, and air-dried naturally to form a nanoporous graphene / nitrocellulose...

Embodiment 3

[0033] (1) Mix the graphene oxide dispersion with the zinc nitrate solution so that the final concentration of the former is 4 g / L, and the latter is 600 g / L, stir and mix evenly, the mixed solution is filtered with filter paper, and then the filter paper and The intercepted mixture was dried in an oven at 55°C, then ignited in an alcohol lamp and fully incinerated. The incineration product was repeatedly washed with 10% hydrochloric acid, then washed with distilled water until the pH was neutral, and the nanoporous graphene was collected by centrifugation;

[0034] (2) Take 0.003 g of nanoporous graphene prepared in step (1), add it to 200 μL ethanol, and after ultrasonic dispersion, add 800 μL nitrocellulose solution (collodion; content: w / %4-8%) to continue Ultrasound and mix uniformly to obtain a mixed solution;

[0035](3) The mixed solution prepared in step (2) was added dropwise to a 35mL petri dish, and air-dried to form a film to obtain a nanoporous graphene / nitrocel...

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Abstract

The invention discloses a preparation method of a nanoporous graphene / nitrocellulose film with the functions of antibacterial and wound healing promotion. The nanoporous graphene is ultrasonically dispersed in ethanol, and the nitrocellulose solution is added to ultrasonic and mixed uniformly to obtain a mixed solution. , and then drop the mixed solution into a petri dish, and air-dry naturally to form a film. The film has good toughness and biocompatibility, has broad-spectrum antibacterial properties and the ability to promote wound healing, and has a good water vapor transmission rate, and has clinical application potential in trauma wound dressings.

Description

technical field [0001] The invention relates to a nanoporous graphene composite material, in particular to a method for preparing a nanoporous graphene / nitrocellulose film with broad-spectrum antibacterial properties and a function of promoting wound healing, belonging to the technical field of composite materials, antibacterial materials and wounds wound dressing. Background technique [0002] The treatment of skin wounds is very important to human health, and the development of new wound dressings with excellent performance has always been a technical hotspot. Currently, nitrocellulose membranes are used for wound healing due to their good biocompatibility and porous network structure to prevent harmful bacteria from entering the wound to avoid wound infection. However, the pore size of the surface pores of the nitrocellulose membrane is too small to affect its water vapor transmission rate, which will lead to the accumulation of wound secretions, and its antibacterial pe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/42A61L15/44A61L15/46
CPCA61L15/28A61L15/18A61L15/425A61L15/42A61L15/44A61L15/46A61L2300/404A61L2300/412A61L2300/108A61L2300/232C08L1/18Y02A50/30
Inventor 邱洪灯杜少博李湛陈佳
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI