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A kind of bionic fibrous ring support and preparation method thereof

A fibrous annulus, bionic technology, applied in textiles and papermaking, spinal implants, non-woven fabrics, etc., can solve the problem that the fibrous annulus support has no mechanical gradient change, cannot provide toughness, and cannot simulate the natural fibrous annulus mechanics Problems such as performance transition, to achieve good biocompatibility, excellent biodegradability and compatibility, excellent multi-layer alternating structure and tensile strain performance

Active Publication Date: 2022-04-05
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, although there have been many related reports on the preparation of artificial fiber rings by electrospinning technology, these scaffold products still do not simulate the structure and performance of natural fiber rings. The main aspects are: (1) Even if the oriented electrospun fibers have high modulus, but it is still in the shape of straight fibers, which cannot provide superior toughness; (2) the annulus fibrosus scaffold has no mechanical gradient change, and cannot simulate the transition of mechanical properties of the natural annulus fibrosus from the softer nucleus pulposus to the harder peripheral annulus fibrosus

Method used

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  • A kind of bionic fibrous ring support and preparation method thereof
  • A kind of bionic fibrous ring support and preparation method thereof
  • A kind of bionic fibrous ring support and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0041] The preparation method of the bionic annulus fibrosus support in this embodiment comprises the following steps, and the preparation process is as follows: figure 1 Shown:

[0042] (1) 0.8g PLLA was dissolved in 10mL trifluoroethanol to prepare 8% polymer spinning precursor solution, and an electrospinning film was prepared by an electrospinning method; The speed is 3mL / h, the spinning needle is a 9G stainless steel needle, the positive voltage applied to the needle is 12kV, the negative voltage of the corresponding disc receiver is -1kV, and the rotating speed of the disc receiver is 3000r / min , the distance between the needle and the receiver is 10cm; the temperature is 25°C, the relative humidity is 65%, and the time is 1.5h. After the electrospun membrane is prepared, it is dried in a vacuum environment for 12h;

[0043] (2) Cut the electrospun membrane into 1×5cm 2 The long strips are fixed on the fixture with 0.5cm at both ends (the actual induced area of ​​the f...

Embodiment 2

[0048] The preparation method of the bionic fibrous ring support in this embodiment comprises the following steps:

[0049] (1) Dissolve 0.8g PCL in 10mL trifluoroethanol to prepare 8% polymer spinning precursor solution, prepare electrospinning film by electrospinning method; syringe pump when preparing electrospinning film by electrospinning method The speed is 2mL / h, the spinning needle is 9G stainless steel needle, the positive voltage applied to the needle is 15kV, the negative voltage of the corresponding disc receiver is -1kV, and the rotating speed of the disc receiver is 3000r / min , the distance between the needle and the receiver is 8cm; the temperature is 20°C, the relative humidity is 60%, and the time is 1h. After the electrospun membrane is prepared, it is dried in a vacuum environment for 12h;

[0050] (2) Cut the electrospun membrane into 1×5cm 2 The long strips are fixed on the fixture with 0.5cm at both ends (the actual induced area of ​​the fiber membrane i...

Embodiment 3

[0054] The preparation method of the bionic fibrous ring support in this embodiment comprises the following steps:

[0055] (1) 0.8g PLCL was dissolved in 10mL trifluoroethanol to prepare 8% polymer spinning precursor solution, and the electrospinning film was prepared by the electrospinning method; the syringe pump was prepared by the electrospinning method The speed is 2.5mL / h, the spinning needle is 9G stainless steel needle, the positive voltage applied to the needle is 18kV, the negative voltage of the corresponding disk receiver is -1kV, and the rotation speed of the disk receiver is 3000r / min, the distance between the needle and the receiver is 9cm; the temperature is 20°C, the relative humidity is 70%, and the time is 1h. After the electrospun membrane is prepared, it is dried in a vacuum environment for 12h;

[0056] (2) Cut the electrospun membrane into 1×5cm 2 The long strips are fixed on the fixture with 0.5cm at both ends (the actual induced area of ​​the fiber ...

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Abstract

The invention discloses a bionic fiber ring support and a preparation method thereof, belonging to the field of biomedical materials. The preparation method of the biomimetic fiber ring scaffold of the present invention obtains a micro-nano fiber membrane with a three-dimensional structure by an electrospinning method, and then induces the fibers to bend and deform with a good orientation degree through the induction of a solvent with specific parameters, and finally the fiber membrane According to a specific cutting and winding method, the bionic fiber ring scaffold product prepared has excellent multi-layer alternating structure and tensile strain performance, and simulates the mechanical property gradient of the human fiber ring, which solves the problem of existing simulated fiber ring tension. The tensile strain performance is poor and the defect of lacking the mechanical gradient change of the natural fibrous annulus, and the extracellular matrix coated between the layers also improves the biocompatibility of the product; the preparation method has simple operation steps and low requirements for equipment. Industrial scale production can be realized. The invention also discloses the bionic fibrous ring support prepared by the preparation method.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a bionic fibrous ring support and a preparation method thereof. Background technique [0002] Intervertebral disc degeneration is a disease that plagues most middle-aged and elderly people and even young people. This symptom often causes low back pain and seriously affects normal life. The intervertebral disc is located between the two vertebral bodies of the human spine and is mainly composed of the central nucleus pulposus, the annulus fibrosus, and the upper and lower cartilage endplates. When the annulus fibrosus is damaged, the internal nucleus pulposus outflows and compresses the nerves causing pain, and the height of the intervertebral disc collapses causing further tissue degeneration. Therefore, the key to the treatment of degenerative disc disease lies in the repair of the annulus fibrosus. From the structural point of view, the fibrous annulus is a multi-layer (N=...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/44D04H1/728
CPCA61F2/442D04H1/728
Inventor 周晶罗紫灵全大萍白莹邓荣力周梓婷张田伟
Owner SUN YAT SEN UNIV
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