Collagenase inhibitor, anti-aging skin-brightening toner containing collagenase inhibitor and preparation methods
A collagenase and inhibitor technology, applied in the field of cosmetics, can solve the problems of difficult to reach the dermis and large molecular weight of hydrolyzed collagen, and achieve the effects of excellent inhibition, improvement of skin elasticity, and simple operation
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[0043]The preparation method of the collagenase inhibitor of the present invention is not particularly limited, and may be a common method in the art, specifically including the step of mixing the components of the collagenase inhibitor. For example, the pomegranate peel extract and the purslane extract are uniformly mixed by conventional mixing.
[0044] Collagenase
[0045] Collagenase belongs to a class of matrix metalloproteinases (Matrix Metalloproteinase, MMPs). Matrix metalloproteinases are a family of endopeptidases whose biological activity depends on zinc ions and has the ability to degrade extracellular matrix (Extra-Cellar Matrix, ECM). The main function of collagenase is to degrade collagen and elastin in the dermis, and its tissue inhibitors (Tissue Inhibitors of Metalloproteinase, TIMPs) specifically inhibit the activity of collagenase by covalently binding to its highly conserved zinc binding site , jointly regulate matrix metabolism and maintain the struct...
Embodiment
[0092] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.
[0093] Red pomegranate peel extract was purchased from: Quzhou Zhanhong Biotechnology Co., Ltd.;
[0094] Purslane extract was purchased from: Quzhou Zhanhong Biotechnology Co., Ltd.
Embodiment 1-5
[0100] Pomegranate peel extract and purslane extract are provided as collagenase inhibitors. Red pomegranate peel extract and purslane extract are by mass ratio 3:1 (embodiment 1), 2:1 (embodiment 2), 1:1 (embodiment 3), 1:2 (embodiment 4) , 1:3 (embodiment 5) after mixing, obtain collagenase inhibitor. The collagenase inhibitors of Examples 1-5 were respectively dissolved in 5 groups of deionized water corresponding to the volumes of Comparative Examples 1-5. Examples 1-5 can obtain 5 groups of test solutions corresponding to the concentrations of Comparative Examples 1-5 (if not corresponding, a separate list). Among them, among the collagenase inhibitors, the content (mass %) of the pomegranate peel extract and the purslane extract is shown in Table 1 below, and the logarithmic mass concentration of the collagenase inhibitor is shown in Table 3 below.
[0101] Table 1
[0102]
[0103] Inhibition of Collagenase Activity Test
[0104] Folin's phenol reagent can be r...
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