Artificial corneal endothelium in corneal stroma and preparation method thereof
A technology of artificial cornea and corneal stroma, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of artificial cornea prolapse, wound leakage, corneal edema relying on donated cornea, etc., and achieve good comfort, medium water content, The effect of good market prospects
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Embodiment 1
[0033] A preparation method for artificial corneal endothelium in corneal stroma, comprising the steps of:
[0034] (1) Preparation of dry silicon hydrogel mold base: the specific steps are as follows:
[0035] S1. Weigh each raw material according to the following mass percentages: 32% of silicon-containing monomer, 44% of hydrophilic monomer, 0.43% of crosslinking agent, 0.26% of photo / thermal initiator, and the rest is solvent;
[0036] S2. After mixing and stirring each component according to the formula amount, pour it into the mold, and polymerize under the conditions of conventional heating or ultraviolet lamp irradiation;
[0037] S3. Place the mold in an alcoholic solvent with a volume fraction of 20% for separation, and collect the silicon hydrogel mold base;
[0038] S4. Place the mold base in isopropanol with a volume fraction of 15% and reform it for 1 hour; isopropanol is used as a cleaning and degreasing agent, which can completely clean the grease material on ...
Embodiment 2
[0046] A preparation method for artificial corneal endothelium in corneal stroma, comprising the steps of:
[0047] (1) Preparation of dry silicon hydrogel mold base: the specific steps are as follows:
[0048] S1. Weigh each raw material according to the following mass percentages: 23% of silicon-containing monomer, 36% of hydrophilic monomer, 0.05% of crosslinking agent, 0.05% of photo / thermal initiator, and the rest is solvent;
[0049] S2. After mixing and stirring each component according to the formula amount, pour it into the mold, and polymerize under the conditions of conventional heating or ultraviolet lamp irradiation;
[0050] S3. The mold is placed in an alcohol solvent with a volume fraction of 10% for separation, and the silicon hydrogel mold base is collected;
[0051] S4. Place the mold base in isopropanol with a volume fraction of 10% and reform it for 1 hour; isopropanol is used as a cleaning and degreasing agent, which can completely clean the grease materia...
Embodiment 3
[0059] A preparation method for artificial corneal endothelium in corneal stroma, comprising the steps of:
[0060] (1) Preparation of dry silicon hydrogel mold base: the specific steps are as follows:
[0061] S1. Weigh each raw material according to the following mass percentages: 40% silicon-containing monomer, 52% hydrophilic monomer, 8% crosslinking agent, 5% photo / thermal initiator, and the rest is solvent;
[0062] S2. After mixing and stirring each component according to the formula amount, pour it into the mold, and polymerize under the conditions of conventional heating or ultraviolet lamp irradiation;
[0063] S3. Place the mold in an alcohol solvent with a volume fraction of 30% for separation, and collect the silicon hydrogel mold base;
[0064] S4. Place the mold base in isopropanol with a volume fraction of 20% and reform it for 1 hour; isopropanol is used as a cleaning and degreasing agent, which can completely clean the grease material on the mold base and im...
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