Essence stock solution, preparation method thereof and collagenase inhibitor

A technology of collagenase and inhibitor, which is applied in the field of essence stock solution and its preparation method and collagenase inhibitor, which can solve problems such as difficulty, and achieve the effects of improving skin elasticity, excellent inhibition, and easy raw materials

Pending Publication Date: 2021-07-16
GUANGZHOU KENENG COSMETICS RES CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the molecular weight of hydrolyzed collagen is too large, and it is difficult to penetrate the skin barrier of the human body to reach the dermis; hyaluronic acid cannot essentially slow down the loss of collagen; peptides and retinol have certain irritation and safety risks to the skin, etc.

Method used

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  • Essence stock solution, preparation method thereof and collagenase inhibitor
  • Essence stock solution, preparation method thereof and collagenase inhibitor
  • Essence stock solution, preparation method thereof and collagenase inhibitor

Examples

Experimental program
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Effect test

preparation example Construction

[0044] The preparation method of the collagenase inhibitor of the present invention is not particularly limited, and may be a common method in the art, for example, a method of mixing is used to uniformly mix the extract of Poria cocos and the extract of Calendula officinalis.

[0045] Collagenase

[0046] Collagenase belongs to a class of matrix metalloproteinases (Matrix Metalloproteinase, MMPs). Matrix metalloproteinases are a family of endopeptidases whose biological activity depends on zinc ions and has the ability to degrade extracellular matrix (Extra-Cellar Matrix, ECM). The main function of collagenase is to degrade collagen and elastin in the dermis, and its tissue inhibitors (Tissue Inhibitors of Metalloproteinase, TIMPs) specifically inhibit the activity of collagenase by covalently binding to its highly conserved zinc binding site , jointly regulate matrix metabolism and maintain the structure of the dermis.

[0047] Collagenases include mesenchymal collagenas...

Embodiment

[0090] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

[0091] Poria cocos extract was purchased from: Nanjing Specco Biochemical Industry Co., Ltd.;

[0092] Calendula extract was purchased from: Quzhou Zhanhong Biotechnology Co., Ltd.

Embodiment 1-5

[0098] Poria cocos extract and calendula flower extract are provided as collagenase inhibitors. With Poria cocos extract and calendula extract by mass ratio 1:10 (embodiment 1), 1:5 (embodiment 2), 1:3 (embodiment 3), 1:1 (embodiment 4), 2 : 1 (embodiment 5) after mixing, obtain collagenase inhibitor.

[0099] The collagenase inhibitor of Example 1 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0100] The collagenase inhibitors of Example 2 were dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0101] The collagenase inhibitor of Example 3 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0102] The collagenase inhibitor of Example 4 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0103] The collagenase inhibitor of Example 5 was dissolved in 5 groups of deionized ...

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PUM

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Abstract

The invention provides an essence stock solution, a preparation method thereof and a collagenase inhibitor. The essence stock solution comprises the collagenase inhibitor and a penetration enhancer, wherein on the basis of the total mass of the essence stock solution, the mass of the added collagenase inhibitor accounts for 0.01%-10%, and the mass of the added penetration enhancer accounts for 0.01%-10%; and the collagenase inhibitor comprises a poria cocos extract and a calendula extract, wherein on the basis of the total mass of the collagenase inhibitor, the mass of the added poria cocos extract accounts for 10%-49%, and the mass of the added calendula extract accounts for 51%-90%. The essence stock solution is mild in formula and can effectively improve skin elasticity, so that an anti-aging effect is achieved.

Description

technical field [0001] The invention relates to an essence stock solution, a preparation method thereof and a collagenase inhibitor, belonging to the field of cosmetics. Background technique [0002] Collagen is mainly produced by fibroblasts in the dermis and is the main component of the dermis. It can maintain the structure of the skin and give the skin toughness and elasticity. The content and distribution of collagen determine the youthfulness of the skin. However, the abnormal reduction of collagen content will cause the thinning of the dermis, loose skin, loss of elasticity, and wrinkles, which will affect people's quality of life. With the deepening of research on collagen, researchers have found that collagenase plays an important role in the homeostasis of skin collagen, and its overexpression and abnormal activation are one of the main causes of skin aging. Therefore, inhibiting the activity of collagenase can block the degradation of skin collagen, increase the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/9728A61Q19/08
CPCA61K8/9789A61K8/9728A61Q19/08A61K2800/782A61K2800/592
Inventor 杨登亮邓慧李传茂张楚标曾伟丹张伟杰
Owner GUANGZHOU KENENG COSMETICS RES CO LTD
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