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Traditional Chinese medicine composition for treating female animal endometritis and its preparation method and application

A technology of endometritis and composition, which is applied in the field of veterinary medicine, can solve problems such as environmental pollution and single mode of action, unfavorable storage of sanguinarine, and easy resistance to antibiotics, so as to avoid instability and maintain stability Effect

Active Publication Date: 2022-04-08
MICOLTA BIORESOURCE INC LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the comparison document, a combination of Chinese and Western medicine is used to treat bacterial endometritis and other diseases. The antibiotics added are prone to drug resistance, resulting in environmental pollution and a relatively single mode of action.
[0005] During the research process, it was found that sanguinarine is unstable in an aqueous solution with a pH value of 5.5-7.0, and basically only 10%-20% remains after being placed for 1-3 months. The extract of Boluohui was extracted in the comparison file , the final preparation form is directly prepared into uterine perfusion solution, which is not conducive to the stable preservation of sanguinarine in Boluohui

Method used

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  • Traditional Chinese medicine composition for treating female animal endometritis and its preparation method and application
  • Traditional Chinese medicine composition for treating female animal endometritis and its preparation method and application
  • Traditional Chinese medicine composition for treating female animal endometritis and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Take 6 kg of Boluo pods, extract by diafiltration with 0.5% sulfuric acid, then use lye to adjust the solution to a pH value of about 10 to precipitate, obtain a precipitate after filtration, dry the precipitate, and dissolve it with 90% ethanol Sulfuric acid solution was added to precipitate, filtered, and after the precipitate was dried, 113.4 g of the extract was returned, and the percentage of sanguinarine was 40.9% as measured by liquid phase.

[0033] (2) Take 4kg of motherwort medicinal material, extract twice with 10 times of water, and concentrate the combined water extract to about 1.10g / cm 3 , add an equivalent amount of 95% ethanol to carry out alcohol precipitation, recover the alcohol liquid and dry it to obtain 365.8g of Motherwort extract, and the stachydrine hydrochloride is 3.2% as measured by the liquid phase.

[0034] (3) Merge the extract of Boluohui and motherwort, add 110 g of sodium citrate and 33 g of sodium carboxymethylcellulose, mix and p...

Embodiment 2

[0036] (1) Take 7.5kg of boluo pods, extract by diafiltration with 0.5% sulfuric acid, then use lye to adjust the solution to a pH value of about 10 to precipitate, obtain a precipitate after filtration, dry the precipitate, and dissolve it with 90% ethanol Then add sulfuric acid solution to precipitate, filter, and after the precipitate is dried, 141.2 g of the extract will be returned, and the percentage of sanguinarine is 41.2% as measured by liquid phase.

[0037] (2) Take 2.5kg of Motherwort herbs, extract twice with 10 times of water, and concentrate the combined water extracts to about 1.10g / cm 3, add an equivalent amount of 95% ethanol to carry out alcohol precipitation, recover the alcohol liquid and dry it to obtain 230.8g of Motherwort extract, and the stachydrine hydrochloride is 3.4% as measured by the liquid phase.

[0038] (3) Merge the extract of Boluohui and motherwort, add 142g of sodium citrate and 33g of sodium carboxymethylcellulose, mix and pack, and ster...

Embodiment 3

[0040] (1) Take 9 kg of Boluo pods, extract by diafiltration with 0.5% sulfuric acid, then use lye to adjust the solution to a pH value of about 10 to precipitate, obtain a precipitate after filtration, dry the precipitate, and dissolve it with 90% ethanol Sulfuric acid solution was added to precipitate, filtered, and after the precipitate was dried, 167.4 g of the extract was returned, and the percentage of sanguinarine was 42.8% as measured by liquid phase.

[0041] (2) Take 1kg of motherwort medicinal material, extract twice with 10 times of water, and concentrate the combined water extract to about 1.10g / cm 3 , add an equivalent amount of 95% ethanol to carry out alcohol precipitation, recover the alcohol liquid and dry it to obtain 92.5g of Motherwort extract, and the stachydrine hydrochloride is 3.1% as measured by the liquid phase.

[0042] (3) Merge the extract of Boluohui and motherwort, add 168g of sodium citrate and 33g of sodium carboxymethylcellulose, mix and pack...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating female animal endometritis and its preparation method and application. The composition includes 60-90 parts of Boluohui and 10-40 parts of Motherwort. Extraction and preparation of Boluohui extract and Motherwort extract respectively, the content of sanguinarine in the Boluohui extract shall not be less than 40%. In the present invention, Boluohui and Motherwort are used for compatible application, with Boluohui as the monarch drug and Leonurus as the subject drug, using the Boluohui extract and Leonurus extract as active ingredients respectively, and using the two combinations to play a role in clearing heat and detoxifying the composition, The effect of promoting blood circulation and removing blood stasis is used to treat endometritis in female animals.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a traditional Chinese medicine composition for treating endometritis in female animals, a preparation method and application thereof. Background technique [0002] In the animal breeding process, especially in breeding stock breeding farms, female endometritis is the most common reproductive system disease in the breeding process. Dairy cows and sows, which are more common among female animals, can be close to half of the total number of female animals suffering from endometritis if they are poorly bred and managed. Current treatment methods mainly rely on antibiotics for local administration in the uterus or oral systemic administration. The disadvantages of antibiotics compared with traditional Chinese medicine preparations for the treatment of endometritis are that they are prone to drug resistance, produce environmental pollution and have a single mod...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/66A61P15/00
CPCA61K36/66A61K36/533A61P15/00A61K2236/333A61K2236/39A61K2236/331A61K2236/51A61K2300/00
Inventor 陈燕乐曾建国杨广民曾诚
Owner MICOLTA BIORESOURCE INC LTD