Preparation method of photo-thermal sensitive composite bacterial cellulose antibacterial dressing

A technology of bacterial cellulose and bacterial cellulose film is applied in the field of preparation of photothermal-sensitive composite bacterial cellulose antibacterial dressings, and achieves the effects of lasting antibacterial effect, low cost, excellent biocompatibility and cell affinity

Inactive Publication Date: 2021-07-23
HAINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, there are few reports on the surface modificatio

Method used

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  • Preparation method of photo-thermal sensitive composite bacterial cellulose antibacterial dressing
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  • Preparation method of photo-thermal sensitive composite bacterial cellulose antibacterial dressing

Examples

Experimental program
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Effect test

Embodiment 1

[0037] The preparation method of photothermal sensitive composite bacterial cellulose antibacterial dressing, specifically comprises the following steps:

[0038] (1) Take bacterial cellulose with a thickness of 0.2cm, wash the surface with water to remove surface impurities, then rinse with deionized water for 3 times, soak in deionized water for 5h, and then use a NaOH aqueous solution with a concentration of 0.1mol / L at 85°C Heat and boil in a water bath for 1 hour to remove the endotoxin in the bacterial cellulose, take it out, rinse it with deionized water for 3 times, and then soak it in deionized water for 5 times to obtain the bacterial cellulose film, and refrigerate at 4°C for later use;

[0039] (2) Get 15 mL of 0.1 mol / L hydrochloric acid solution and mix 50 mL of 0.1 mol / L Tris solution, dilute to 100 mL to obtain Tris-HCl buffer solution, add 0.124 g of dopamine hydrochloride to obtain a dopamine buffer solution with a concentration of 1.0 mg / mL, Then add the bacte...

Embodiment 2

[0045] The preparation method of photothermal sensitive composite bacterial cellulose antibacterial dressing, specifically comprises the following steps:

[0046] (1) Take bacterial cellulose with a thickness of 0.2cm, wash the surface with water to remove surface impurities, then rinse twice with deionized water, soak in deionized water for 3h, and then use a NaOH aqueous solution with a concentration of 0.1mol / L at 80°C Heated and boiled in a water bath for 1 hour to remove endotoxin in the bacterial cellulose, rinsed twice with deionized water after taking it out, and then soaked in deionized water for 3 times to obtain bacterial cellulose membrane, refrigerated at 4°C for later use;

[0047] (2) Get 15 mL of 0.1 mol / L hydrochloric acid solution and mix 50 mL of 0.1 mol / L Tris solution, dilute to 100 mL to obtain Tris-HCl buffer solution, add 0.62 g of dopamine hydrochloride to obtain a dopamine buffer solution with a concentration of 0.5 mg / mL, Then add the bacterial cellu...

Embodiment 3

[0050] The preparation method of photothermal sensitive composite bacterial cellulose antibacterial dressing, specifically comprises the following steps:

[0051] (1) Take bacterial cellulose with a thickness of 0.2 cm, wash the surface with water to remove surface impurities, then rinse with deionized water for 3 times, soak in deionized water for 5 hours, and then use a NaOH aqueous solution with a concentration of 0.1mol / L at 90°C Heat and boil in a water bath for 1 hour to remove the endotoxin in the bacterial cellulose, take it out, rinse it with deionized water for 3 times, and then soak it in deionized water for 5 times to obtain the bacterial cellulose film, and refrigerate at 4°C for later use;

[0052] (2) Get 15 mL of 0.1 mol / L hydrochloric acid solution and 50 mL of 0.1 mol / L Tris solution and mix, dilute to 100 mL to obtain Tris-HCl buffer solution, add 0.248 g of dopamine hydrochloride to obtain a dopamine buffer solution with a concentration of 2.0 mg / mL, Then a...

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Abstract

The invention discloses a preparation method of a photo-thermal sensitive type composite bacterial cellulose antibacterial dressing. The preparation method specifically comprises the following steps: (1) washing the surface of bacterial cellulose with water, performing rinsing and soaking, performing heating and boiling in a water bath with alkali liquor, repeatedly soaking and washing the bacterial cellulose until the bacterial cellulose is neutral, and performing refrigerating for later use; (2) preparing a dopamine buffer solution, adding a bacterial cellulose membrane, performing lighting, ventilating and standing to react, performing soaking and washing for multiple times until the solution is neutral after reaction, and performing refrigerating for later use; and (3) preparing a chloroauric acid solution, then adding the bacterial cellulose membrane after the surface of polydopamine is modified, performing standing at an opened state to react, performing repeated soaking and washing until the solution is neutral, and performing refrigerating for later use. The antibacterial dressing has excellent mechanical property and adhesion property, the polydopamine and the nanogold are synergized in the photo-thermal effect, photo heat is transformed into high temperature through energy input of low-power near-infrared light, so that a better thermal efficacy sterilization effect is generated, and the antibacterial dressing has a simple preparation process, mild reaction condition and good biocompatibility.

Description

technical field [0001] The invention relates to the technical field of composite materials, in particular to a preparation method of a photothermal-sensitive composite bacterial cellulose antibacterial dressing. Background technique [0002] Medical dressing is a material widely used in clinical surgical fields such as skin trauma and burn treatment. Excellent medical dressing requires good biological safety, barrier properties, water absorption and water retention, and suitable mechanical properties. Traditional dressings are mainly gauze, cotton pads, and gauze composite materials, etc., which are affordable, have a wide range of raw materials, and are relatively easy to prepare. They currently occupy a major position in the market. However, the hemostatic effect of traditional dressings is not good, and the permeability is poor. When the dressing is removed, it is easy to cause skin adhesion, destroy the newly formed epithelial cells, cause bleeding, and cannot quickly ab...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/26A61L15/18A61L15/42A61L15/46A61L15/50A61K41/00A61P31/04
CPCA61L15/28A61L15/26A61L15/18A61L15/42A61L15/46A61L15/50A61K41/0052A61P31/04A61L2300/404A61L2300/102A61L2400/12C08L1/02C08L79/02A61K2300/00
Inventor 李萌婷李昌贵尹学琼邓乔元洪季璇杜雨菡
Owner HAINAN UNIVERSITY
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