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Preparation method of cationic waterborne polyurethane for treating onychomycosis

A water-based polyurethane and cationic technology, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of high irritation, skin burns, etc., and achieve increased hardness, green source, The effect of increasing strength

Pending Publication Date: 2021-07-23
HEFEI KETIAN WATERBORNE TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although 20% glacial acetic acid has a bactericidal effect, it is very irritating, burns the skin around the nails, and even causes paronychia and other symptoms

Method used

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  • Preparation method of cationic waterborne polyurethane for treating onychomycosis
  • Preparation method of cationic waterborne polyurethane for treating onychomycosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 145g of PO3G2000 with a molecular weight of 2000 and 130g of toluene diisocyanate were heated to 85°C for 2 hours, and the NCO content was measured for two hours. After reaching the theoretical value, the temperature was lowered to 40°C, and 38g of 1,4-butanediol, 1.58g of Myricetin and a small amount of acetone to adjust the viscosity, heat up to 80°C for 2 hours, add 0.8g of Coscat83 catalyst and 45mL of acetone after the time is up, heat up to 60°C for 3h, then test the NCO value, after reaching the theoretical value, cool down and add 90mL of acetone Adjust the viscosity to 20-30S (at 25°C), lower the temperature to 40°C, then add 22g of N-methyldiethanolamine slowly within 30 minutes by dropwise addition, react at 40°C for 1 hour, and then cool down to 0- 5°C to obtain the prepolymer; pour the prepolymer into a plum blossom bucket, then add 20g of lactic acid at a speed of 800r / min, disperse for 10min, increase the speed to 1800r / min, add 660g of deionized emulsifie...

Embodiment 2

[0024] 140g of PO3G2000 with a molecular weight of 2000 and 140g of toluene diisocyanate were heated to 85°C for 4 hours, and the NCO content was measured once every two hours. After reaching the theoretical value, the temperature was lowered to 40°C, and 40g of 1,6-hexanediol, 2g Myricetin and a small amount of acetone to adjust the viscosity, heat up to 80°C for 2 hours, add 0.7g organic bismuth 2010 catalyst and 45mL of acetone after the time is up, heat up to 60°C for 3h, then test the NCO value, cool down and add 90mL after reaching the theoretical value Adjust the viscosity to 20-30S (at 25°C) with acetone, then add 21g of N-methyldiethanolamine slowly within 30 minutes by dropwise addition, react at 40°C for 1 hour, and then cool down to 0-5°C to obtain Prepolymer: Pour the prepolymer into a plum blossom bucket, then add 19g of lactic acid at a speed of 800r / min, and after dispersing for 10min, increase the speed to 2000r / min, add 680g of deionized emulsified water, and ...

Embodiment 3

[0026] 155g of PO3G2000 with a molecular weight of 2000 and 123g of toluene diisocyanate were heated to 85°C for 4 hours, and the NCO content was measured once every two hours. After reaching the theoretical value, the temperature was lowered to 40°C, and 36g of diethylene glycol, 1.8g Myricetin and a small amount of acetone to adjust the viscosity, heat up to 80°C for 2 hours, add 0.9g Coscat83 catalyst and 45mL of acetone after the time is up, heat up to 60°C for 3h, then test the NCO value, after reaching the theoretical value, cool down and add 90mL of acetone to adjust The viscosity is 20-30S (at a temperature of 25°C), and then slowly add 20.58g of N-methyldiethanolamine in 30 minutes by means of dropwise addition, react at 40°C for 1 hour, and then cool down to 0-5°C to obtain the desired Polymer; Pour the prepolymer into the plum blossom bucket, then add 18.69g of lactic acid at a speed of 800r / min, after dispersing for 10min, increase the speed to 2000r / min, add 672g o...

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Abstract

The invention relates to the field of high-molecular polymers, and particularly discloses a preparation method of cationic waterborne polyurethane for treating onychomycosis. The waterborne polyurethane is prepared from macromolecular polyol, polyisocyanate, a micromolecular alcohol chain extender, myricetin, a catalyst, a hydrophilic chain extender and a neutralizer. The myricetin is introduced into a cationic waterborne polyurethane molecular chain, so that the hardness, wear resistance, water resistance and chemical resistance of the waterborne polyurethane resin are improved, the strength of the waterborne polyurethane resin is improved, the myricetin has antibacterial and antiviral effects, the effect is mild, and side effects such as paronychia are avoided; the myricetin can be extracted from folium artemisiae argyi, and the source is green and environment-friendly.

Description

technical field [0001] The invention relates to the field of polymers, and specifically discloses a cationic water-based polyurethane for treating onychomycosis. Background technique [0002] Our country is affected by many factors such as geographical location and climate. According to statistics from authoritative departments, about 56% of the population has tinea pedis, and more than 35% of them have onychomycosis. That is to say, 19.6% of normal people have tinea pedis. Onychomycosis has a higher incidence rate among people over 30 years old, and more than 70% of people with hand, foot skin and finger (toe) nail problems. And each person has at least 2 or more on average. Because the fungus (dermatophyte, saccharomycete, mold) for the treatment of onychomycosis has extremely strong reproduction and infectivity, it will also increase sharply with a ratio of 15-20% every year. [0003] Onychomycosis and tinea pedis are intractable infectious diseases caused by pathogenic...

Claims

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Application Information

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IPC IPC(8): C08G18/32C08G18/66A61K31/7048A61K47/59A61P17/00A61P31/10A61P31/12
CPCC08G18/3206C08G18/3218C08G18/3275C08G18/66A61K31/7048A61K47/593A61P31/10A61P17/00A61P31/12
Inventor 戴家兵汪飞朱保凌赵曦李维虎
Owner HEFEI KETIAN WATERBORNE TECH CO LTD