Epileptic focus positioning deep brain flexible micro-nano electrode array and preparation method thereof

Abstract

The invention provides an epileptic focus positioning deep brain flexible micro-nano electrode array and a preparation method thereof. The epileptic focus positioning deep brain flexible micro-nano electrode array sequentially comprises a substrate layer, a conductive layer and an insulating layer from bottom to top. The substrate layer and the insulating layer are made of flexible materials with biocompatibility and are in a sharp knife type outline; the conductive layer comprises a microelectrode array and a bonding pad; the microelectrode array comprises a plurality of detection sites; the plurality of detection sites are longitudinally distributed in a staggered manner and longitudinally cross a hippocampal brain region and a cortical brain region; the bonding pad is connected with the microelectrode array through a lead; the insulating layer covers the lead and exposes the microelectrode array and the bonding pad. According to the invention, the flexible micro-nano electrode array is utilized to simultaneously detect, regulate and control single cell action potential signals, cell population field potential signals and real-time fluctuating neurotransmitter signals of cross-sea horses and corticoencephalic regions, which is beneficial to analysis of space-time diffusion of epileptic activities and realization of accurate positioning of epileptic lesions, so that surgical planning and navigation are guided.

Description

technical field [0001] The disclosure relates to the field of micromachining of biosensors, in particular to a flexible micro-nano electrode array for locating epilepsy foci deep in the brain and a preparation method thereof. Background technique [0002] Epilepsy is a common neurological disorder characterized by recurrent abnormal electrical discharges in the brain accompanied by tonic limb convulsions and confusion. Due to the complex mechanism of epilepsy, the detection and localization of epilepsy are still key issues to be solved. [0003] The cerebral cortex and hippocampus are the key focus areas of epileptic seizures. The cortical brain area receives signals from other tissues, integrates and transmits information to the hippocampal subregion; the hippocampal brain area is responsible for cognition, learning and memory functions. Among them, the electrophysiological and electrochemical activities of neurons carry a large amount of information, and show obvious abn...

AI Technical Summary

Problems solved by technology

The Young’s modulus of the commonly used rigid silicon-based electrodes is quite different from that of the brain tissue, which will cause certain damage to the flexible brain tissue and trigger an inflammatory response

Moreover, silicon-based electrodes are brittle and easy to damage

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