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Transdermal drug delivery preparation for treating knee osteoarthritis and preparation method thereof

A transdermal drug delivery technology for knee osteoarthritis, applied in anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., can solve problems such as poor compliance, severe pain in patients, and inaccurate dosage. Achieve the effect of improving stability, promoting drug absorption and prolonging drug effect

Active Publication Date: 2021-08-10
贵州中医药大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage of this method is inaccurate, and there is cross-infection. Although the crossbow medicine needle has been improved clinically, the pain of the patient is still severe during treatment, and the compliance is poor.

Method used

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  • Transdermal drug delivery preparation for treating knee osteoarthritis and preparation method thereof
  • Transdermal drug delivery preparation for treating knee osteoarthritis and preparation method thereof
  • Transdermal drug delivery preparation for treating knee osteoarthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0165] Embodiment 1. a kind of microemulsion for the treatment of knee osteoarthritis, get Aconitum aconitum 20g, Bailongxu 15g, Caulis vulgaris 30g, Saccharomyces osmanthus 50g and Caulis japonica 50g;

[0166] Add 12 times the amount of 70% ethanol of the above medicinal materials, reflux extraction, each extraction for 1 hour, a total of 3 extractions, filter, recover ethanol under reduced pressure, and vacuum dry to obtain a dry extract. Take 1.5g of isopropyl myristate, 8.625g of polyoxyethylene castor oil-35, and 2.875g of absolute ethanol in a vial, set the temperature of the magnetic stirrer to 25°C, and the rotation speed to 300r / min, and stir under these conditions , after stirring evenly, add 1.5g dry extract, continue to stir, add 37g water, continue to stir until fully emulsified, promptly make this microemulsion.

[0167] Usage and dosage: Crossbow medicine wine is clinically used to treat knee osteoarthritis. Use needles dipped in the medicinal liquid to punctur...

Embodiment 2

[0168] Embodiment 2. A kind of microemulsion for the treatment of knee osteoarthritis, get Aconitum aconitum 50g, Bailongxu 50g, Heiguteng 50g, Toguxiang 300g and Daxueteng 30g; add 70 g of 12 times the amount of above-mentioned medicinal materials % ethanol, reflux extraction, each extraction 1h, a total of 3 extractions, filtration, recovery of ethanol under reduced pressure, vacuum drying to obtain dry extract. Take 1.5g of isopropyl myristate, 8.625g of polyoxyethylene castor oil-35, and 2.875g of absolute ethanol in a vial, set the temperature of the magnetic stirrer to 25°C, and the rotation speed to 300r / min, and stir under these conditions , after stirring evenly, add 1.5g dry extract, continue to stir, add 37g water, continue to stir until fully emulsified, promptly make this microemulsion.

[0169] Usage and dosage are the same as in Example 1.

Embodiment 3

[0170] Embodiment 3. A kind of microemulsion for the treatment of knee osteoarthritis, get Aconitum aconitum 40g, Bailongxu 25g, Heiguteng 40g, Toguxiang 70g and Daxueteng 70g; add 70g of 12 times the amount of the above-mentioned medicinal materials % ethanol, reflux extraction, each extraction 1h, a total of 3 extractions, filtration, recovery of ethanol under reduced pressure, vacuum drying to obtain dry extract. Take 1.5g of isopropyl myristate, 8.625g of polyoxyethylene castor oil-35, and 2.875g of absolute ethanol in a vial, set the temperature of the magnetic stirrer to 25°C, and the rotation speed to 300r / min, and stir under these conditions , after stirring evenly, add 1.5g dry extract, continue to stir, add 37g water, continue to stir until fully emulsified, promptly make this microemulsion.

[0171] Usage and dosage are the same as in Example 1.

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PUM

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Abstract

The invention discloses a transdermal drug delivery preparation for treating knee osteoarthritis and a preparation method thereof. The transdermal drug delivery preparation is prepared from radix aconiti kusnezoffii, white dragon's hair, periploca forrestii schltr, gaultheria yunnanensis and sargentgloryvine stem. The medicine disclosed by the invention has the effects of promoting blood circulation to arrest pain, removing dampness and dissipating blood stasis, and relaxing tendons and activating collaterals, and can effectively treat knee osteoarthritis; the prepared microemulsion is small in particle size, improves the drug stability, promotes drug absorption, is high in biocompatibility, can prolong the action time of the drug, and achieves the purpose of prolonging the drug effect.

Description

technical field [0001] The invention relates to a transdermal drug delivery preparation (also known as crossbow drug) for treating knee osteoarthritis and a preparation method thereof, belonging to the field of pharmaceutical technology. Background technique [0002] Crossbow powder was first recorded in the "Xuhanshu" (Wuxingzhi) published during the Western Jin Dynasty in China from 266 to 316 BC. According to legend, when the ancestors of the Miao nationality were hunting, they often extracted "crossbow medicine" from some highly poisonous drugs to achieve the effect of "sealing the throat at the sight of blood" and poisoning the prey. In the long-term practice of production and life, the ancestors of the Miao nationality have discovered through thousands of practices that adding some medicines for promoting blood circulation, chasing wind, repelling poison and water to the crossbow medicine can achieve the effect of curing diseases. Afterwards, attenuated drugs are adde...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61K9/107A61K47/14A61K47/44A61P19/02A61P29/00
CPCA61K36/714A61K36/185A61K36/27A61K36/45A61K9/0014A61K9/1075A61K47/44A61K47/14A61P19/02A61P29/00A61K2236/333A61K2236/39A61K2236/53A61K2236/51A61K2300/00
Inventor 张永萍徐剑刘耀杨芳芳缪艳燕曹国琼成雪
Owner 贵州中医药大学
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