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A kind of mesoporous silica-lipid composite nanomaterial and its preparation method and application

A composite nanomaterial, mesoporous silica technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of increasing the risk of thrombosis and tumor metastasis, damage to the vascular system, poor biodegradability, etc., and achieve a short preparation cycle. , The effect of inhibiting tumor growth and low cost

Active Publication Date: 2022-07-15
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, tumor vascular repair may damage normal vasculature, increasing the risk of thrombus and tumor metastasis
In addition, due to size limitation and poor biodegradability, large-sized mesoporous silica nanoparticles are difficult to remove from the body and easily cause biological toxicity.
[0004] The above-mentioned mesoporous silica nanomaterials have some serious problems in tumor therapy as drug carriers, which limit their further application.

Method used

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  • A kind of mesoporous silica-lipid composite nanomaterial and its preparation method and application
  • A kind of mesoporous silica-lipid composite nanomaterial and its preparation method and application
  • A kind of mesoporous silica-lipid composite nanomaterial and its preparation method and application

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Embodiment 1

[0033] In the present embodiment, a preparation process of a mesoporous silica-lipid composite nanomaterial includes:

[0034] Dissolve 1.67g CTAB in a mixed solvent of 200mL deionized water and 31μL ammonia water, place it in a 30°C water bath and stir for 30min until CTAB is completely dissolved, then add 1.28mL methyl orthosilicate and 1.5mL 3-aminopropyl trisulfate. Ethoxysilane, continue to stir in a 30°C water bath for 24 hours; freeze-dry to obtain aminosilica nanomaterials. 500 mg of aminosilica nanomaterials were placed in 120 mL of mixed solvent composed of 90% ethanol and 10% hydrochloric acid, and after stirring at 70°C for 24 hours, the supernatant solution was removed by centrifugation, washed with ethanol and deionized water for several times, and vacuumized. Dry to obtain amino mesoporous silica nanomaterials. 10 mg of amino-mesoporous silica nanomaterials were dispersed in 5 mL of deionized water, and then transferred into a lipid membrane (the The preparation...

Embodiment 2

[0041] In the present embodiment, a preparation process of a mesoporous silica-lipid composite nanomaterial includes:

[0042] Dissolve 2g CTAB in a mixed solvent of 200mL deionized water and 63μL ammonia water, place it in a 40°C water bath and stir for 30min until CTAB is completely dissolved, then add 1.5mL methyl orthosilicate and 2mL 3-aminopropyl triethoxy base silane, continue to stir in a 40°C water bath for 16 hours; freeze-dry to obtain aminosilica nanomaterials. 500 mg of aminosilica nanomaterials were placed in 120 mL of mixed solvent composed of 90% ethanol and 10% hydrochloric acid, and after stirring at 70°C for 24 hours, the supernatant solution was removed by centrifugation, washed with ethanol and deionized water for several times, and vacuumized. Dry to obtain amino mesoporous silica nanomaterials. 10 mg of amino-mesoporous silica nanomaterials were dispersed in 5 mL of deionized water, and then transferred into a lipid film prepared in advance by 35.4 mg o...

Embodiment 3

[0049] In the present embodiment, a preparation process of a mesoporous silica-lipid composite nanomaterial includes:

[0050] Dissolve 2g CTAB in a mixed solvent of 240mL deionized water and 63μL ammonia water, place it in a 25°C water bath and stir for 30min until CTAB is completely dissolved, then add 2mL methyl orthosilicate and 2.5mL 3-aminopropyl triethoxy base silane, continue to stir in a 30°C water bath for 12 hours; freeze-dry to obtain aminosilica nanomaterials. 500 mg of aminosilica nanomaterials were placed in 120 mL of mixed solvent composed of 90% ethanol and 10% hydrochloric acid, and after stirring at 70°C for 24 hours, the supernatant solution was removed by centrifugation, washed with ethanol and deionized water for several times, and vacuumized. Dry to obtain amino mesoporous silica nanomaterials. 5 mg of amino-mesoporous silica nanomaterials were dispersed in 5 mL of deionized water, and then transferred into a lipid membrane (the The preparation is obta...

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Abstract

The invention discloses a mesoporous silica-lipid composite nanomaterial, a preparation method and application thereof, which are composed of amino mesoporous silica and lipid, wherein the mass ratio of amino mesoporous silica and lipid is (5-20): (20-44). The invention provides a mesoporous silica-lipid composite nanomaterial, which is in the form of a core-shell nanoparticle structure. The particle size of the dried particles under an electron microscope is about 20 nm, and the hydrated particle size is about 32 nm under neutral conditions. Upon triggering, the hydrated particle size was reduced to about 17 nm. When injected intravenously into tumor-bearing mice, the mesoporous silica-lipid composite nanomaterials can effectively accumulate in tumor tissue, and then in the acidic environment of tumor tissue, the particle size is reduced, enabling deep penetration of tumor tissue. After being loaded with anticancer drugs, the nanomaterial can effectively kill tumor cells and significantly inhibit tumor growth.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, in particular to a mesoporous silica-lipid composite nanomaterial and a preparation method and application thereof. Background technique [0002] The use of nanomaterials to load chemotherapeutic drugs can help reduce the systemic toxicity of drugs, improve the circulation of drugs in the body and improve the therapeutic effect of drugs, which plays an important role in tumor treatment. The distribution of nanomaterials in tumor tissue directly affects the therapeutic effect of their loaded drugs. Research by the Canadian Cancer Research Center has shown that the volatilization of antitumor drug efficacy depends on the effective accumulation and deep penetration of drug-loaded nanomaterials in tumor tissue (Nat. Rev. Cancer 2006, 6:583-592). In addition, many scientists at home and abroad have shown that it is difficult for drug-loaded nanomaterials to penetrate into the deep pa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/04A61K47/22A61K47/24A61K31/704A61P35/00B82Y5/00B82Y40/00
CPCA61K47/02A61K47/22A61K47/24A61K31/704A61P35/00B82Y5/00B82Y40/00
Inventor 何勇菊
Owner CENT SOUTH UNIV
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