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Anti-restenosis 3D printing self-expansion degradable intravascular stent and preparation method thereof

A 3D printing, vascular stent technology, applied in coating, medical science, surgery, etc., can solve the problems of low biocompatibility of implanted biomaterials, hindering the long-term clinical success of interventional therapy, etc. Good elasticity and short time effect

Active Publication Date: 2021-08-10
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to uncontrollable drug release, low biocompatibility of implanted biomaterials, active inflammatory response, induction of migration and proliferation of smooth muscle cells, and adhesion of platelets, etc., lead to serious complications such as late stent restenosis and thrombosis , hindering the long-term clinical success of the intervention

Method used

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  • Anti-restenosis 3D printing self-expansion degradable intravascular stent and preparation method thereof
  • Anti-restenosis 3D printing self-expansion degradable intravascular stent and preparation method thereof
  • Anti-restenosis 3D printing self-expansion degradable intravascular stent and preparation method thereof

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Effect test

Embodiment 1

[0040] Such as Figure 5 As shown, a preparation method for anti-restenosis 3D printing self-expanding degradable vascular stent, comprising the following steps:

[0041] (1) Preparation of heparin-like / selenocystamine / acryloyl-modified chitosan: chitosan was mixed with chlorosulfonic acid, chloroacetic acid, and selenocystamine in sequence according to the molar ratio of 20:10:10:5:1 and acryloyl chloride reaction, wherein the molar mass of chitosan is calculated according to the molecular weight of the repeating unit of 161g / mol, and the hydroxyl and amino groups on the chitosan molecule are modified with sulfonic acid groups, carboxyl groups, selenocystamine groups and acryloyl groups, and regulated Grafting rate, prepared heparan / selenocystamine / acryloyl modified chitosan, the specific reaction formula is as follows figure 1 shown;

[0042] (2) Preparation of degradable hydrophilic layer 3D printing ink: the heparan / selenocystamine / acryloyl-modified chitosan obtained in...

Embodiment 2

[0046] Such as Figure 5 As shown, a preparation method for anti-restenosis 3D printing self-expanding degradable vascular stent, comprising the following steps:

[0047] (1) Preparation of heparin-like / selenocystamine / acryloyl-modified chitosan: Chitosan was mixed with chlorosulfonic acid, chloroacetic acid, and selenocystamine in sequence according to the molar ratio of 30:10:10:5:1 and acryloyl chloride reaction, wherein the molar mass of chitosan is calculated according to the molecular weight of the repeating unit of 161g / mol, and the hydroxyl and amino groups on the chitosan molecule are modified with sulfonic acid groups, carboxyl groups, selenocystamine groups and acryloyl groups, and regulated Grafting rate, prepared heparan / selenocystamine / acryloyl modified chitosan, the specific reaction formula is as follows figure 1 shown;

[0048] (2) Preparation of degradable hydrophilic layer 3D printing ink: the heparan / selenocystamine / acryloyl-modified chitosan obtained in...

Embodiment 3

[0052] Such as Figure 5 As shown, a preparation method for anti-restenosis 3D printing self-expanding degradable vascular stent, comprising the following steps:

[0053] (1) Preparation of heparin-like / selenocystamine / acryloyl-modified chitosan: Chitosan was sequentially mixed with chlorosulfonic acid, chloroacetic acid, and selenocystamine at a molar ratio of 15:10:10:5:1 and acryloyl chloride reaction, wherein the molar mass of chitosan is calculated according to the molecular weight of the repeating unit of 161g / mol, and the hydroxyl and amino groups on the chitosan molecule are modified with sulfonic acid groups, carboxyl groups, selenocystamine groups and acryloyl groups, and regulated Grafting rate, prepared heparan / selenocystamine / acryloyl modified chitosan, the specific reaction formula is as follows figure 1 shown;

[0054] (2) Preparation of degradable hydrophilic layer 3D printing ink: the heparan / selenocystamine / acryloyl-modified chitosan obtained in step (1), ...

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Abstract

The invention discloses an anti-restenosis 3D printing self-expansion degradable intravascular stent and a preparation method thereof. The modified heparinoid / selenocystamine / acryloyl chitosan, degradable hydrophilic layer 3D printing ink and degradable hydrophobic layer 3D printing ink are prepared, a hydrophilic layer and a hydrophobic layer of the intravascular stent are printed through a double-nozzle 3D printer, water-response self-driven expanding and expanding of narrow blood vessels are achieved through ultraviolet irradiation curing forming and chemical crosslinking bonding and bonding between the hydrophilic layer and the hydrophobic layer, driving deformation of the hydrophilic layer is achieved through printing grid design, and the 3D printing self-expanding degradable intravascular stent resistant to restenosis is formed through plane grid-shaped distortion expansion. The 3D printing self-expanding degradable intravascular stent prepared by the preparation method disclosed by the invention is short in deformation driving time, free of cytotoxicity and capable of efficiently and durably catalyzing endogenous RSNO to release NO, so that rapid endothelialization, smooth muscle cell migration and proliferation resistance and platelet adhesion and activation resistance are promoted, and the target of resisting vascular restenosis is achieved.

Description

technical field [0001] The invention relates to the technical field of degradable vascular stents, in particular to an anti-restenosis 3D printed self-expanding degradable vascular stent and a preparation method thereof. Background technique [0002] According to the WHO2018 report of the World Health Organization, cardiovascular disease has become the number one killer threatening human health. Stent intervention is currently the most common and effective treatment for cardiovascular diseases. However, the new degradable anti-restenosis stent (immediately after implantation provides support for diseased blood vessels and effectively inhibits restenosis; after the completion of vascular repair, it is completely degraded, Restoring the normal physiological function of blood vessels) is still a challenge. [0003] The World Health Organization (WHO) 2018 report pointed out that cardiovascular disease has surpassed tumors to become the number one killer that seriously threaten...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/14A61L31/16B33Y70/10B33Y70/00B33Y10/00B33Y80/00
CPCA61L31/10A61L31/14A61L31/16B33Y70/10B33Y70/00B33Y10/00B33Y80/00A61L2300/232A61L2300/42A61L2300/606C08L5/08C08L5/00
Inventor 郭会龙薛巍周小雁马栋
Owner JINAN UNIVERSITY
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