The invention provides a shakeproof module with multiple cushioning chambers, and relates to the shakeproof technical field. The shakeproof module comprises an outer side film, an inner side film, a first side plate, a second side plate, a third side plate, a fourth side plate and a fifth side plate, wherein the inner side film is fixed on the outer side film in a heat sealing mode, and the first side plate, the second side plate, the third side plate, the fourth side plate and the fifth side plate are formed by sequentially bending. The first cushioning chamber is formed by the second side plate, the third side plate and the fourth side plate in a surrounding mode, the second cushioning chamber and a containing cavity are formed by the first side plate and the fifth side plate in a heat sealing mode, the included angle of the preset angle is formed between the first cushioning chamber and the second cushioning chamber, and the first side plate, the second side plate, the third side plate, the fourth side plate and the fifth side plate are provided with inflatable air chambers formed by the outer side film and the inner side film respectively. According to the scheme, shakeproof structures in the different directions are formed, and the problems that an existing shakeproof product is limited in cushioning ability, and supporting strength is insufficient are solved.