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Enhanced adsorbable lumina bracket and preparation method thereof

An enhanced, absorbing tube technology, applied in the field of luminal stents, can solve problems such as unfavorable surgical operations and stent implantation, unfavorable luminal tissue repair and regeneration, and inability to adhere closely to tissues, etc., to achieve convenient clinical implantation , conducive to repair and regeneration, and beneficial to the effect of clinical operations

Inactive Publication Date: 2019-06-07
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, materials with high mechanical strength, such as polylactic acid and polyglycolide, have insufficient flexibility and cannot be fully compressed after being made into a stent, which is not conducive to surgical operation and stent implantation. Tight attachment is not conducive to the repair and regeneration of the human body's own luminal tissue; and materials with good flexibility, such as polydioxanone, polytrimethylene carbonate, etc., have insufficient support strength after being made into a stent, especially when they degrade During the process, the strength of the stent drops too fast, causing the stent to fall off or break prematurely, endangering the health of the patient.

Method used

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  • Enhanced adsorbable lumina bracket and preparation method thereof
  • Enhanced adsorbable lumina bracket and preparation method thereof
  • Enhanced adsorbable lumina bracket and preparation method thereof

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Experimental program
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Embodiment 1

[0032] An enhanced absorbable luminal stent, the enhanced absorbable luminal stent uses a medical nanofiber-reinforced composite material, the medical nanofiber-reinforced composite material is composed of a base material and nano short fibers, and the nano short fibers maintain a crystalline form Uniformly dispersed in the base material, the mass percentage of nano-short fibers in the composite material is 5%; the base material is polydioxanone; the nano-short fibers are crystalline polyester materials, and the crystalline The polyester material is polyglycolide; the nano short fiber has a diameter of 100 nm and a length of 1 μm.

Embodiment 2

[0034] An enhanced absorbable luminal stent, the enhanced absorbable luminal stent uses a medical nanofiber-reinforced composite material, the medical nanofiber-reinforced composite material is composed of a base material and nano short fibers, and the nano short fibers maintain a crystalline form Uniformly dispersed in the base material, the mass percentage of nano-short fibers in the composite material is 30%; the base material is polytrimethylene carbonate; the nano-short fibers are crystalline polyester materials, and the crystalline poly The ester material is polyglycolide; the nano short fiber has a diameter of 500nm and a length of 50μm.

Embodiment 3

[0036] An enhanced absorbable luminal stent, the enhanced absorbable luminal stent uses a medical nanofiber-reinforced composite material, the medical nanofiber-reinforced composite material is composed of a base material and nano short fibers, and the nano short fibers maintain a crystalline form Uniformly dispersed in the base material, the mass percentage of nano-short fibers in the composite material is 45%; the base material is polydioxanone; the nano-short fibers are crystalline polyester materials, and the crystalline The polyester material is polylactide; the nano short fiber has a diameter of 200nm and a length of 10μm.

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Abstract

The invention discloses an enhanced adsorbable lumina bracket and a preparation method thereof. The enhanced adsorbable lumina bracket is made from a medical nanofiber enhanced composite, and the nanofiber enhanced composite consists of a base material and nanometer short fibers, wherein the nanometer short fibers can maintain a crystal form and is uniformly dispersed to the base material. The lumina bracket is prepared from a nanofiber enhanced material. The material adopts polycaprolactone, poly(trimethylene carbonate) and polydioxanone as flexible base materials, and adopts polylactide or polyglycolide acid short fibers as support materials, so that the support strength is improved, the bracket elasticity is improved, contraction and transportation are easy to realize, and clinical implantation is convenient. The made bracket has enough support properties and reserves flexibility. After being used, the bracket is good in jointing degree with tissue, and is high in strength. Repair and regeneration of self lumina tissue of human bodies are facilitated, and the degradation speed is moderate. Clinical operation of the bracket is facilitated, and the prospective treatment effect isachieved.

Description

technical field [0001] The invention relates to the technical field of luminal stents, in particular to an enhanced absorbable luminal stent and a preparation method thereof. Background technique [0002] The stenosis or obstruction of the human lumen due to trauma, disease, surgery, etc. usually affects the function of tissues and organs, and in severe cases will threaten the life and health of patients. Implanting luminal stents into narrow or obstructed parts is an ideal treatment for such diseases It is beneficial to lumen reconstruction and reduces the incidence of complications. Commonly used luminal stents include esophageal stents, intestinal stents, urethral stents, biliary stents, and nasal cavity stents; existing luminal stent products are mostly made of metal, such as 316L Stainless steel, nickel-titanium alloy, cobalt-chromium alloy, etc. are made of metal weaving or carving. This type of stent has high mechanical strength, good toughness, and is easy to compres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/14D01F6/62
CPCA61L31/129A61L31/14A61L31/148A61L2400/12C08L67/04
Inventor 刘阳王宪朋董浩朱爱臣马丽霞吴倩倩李俊起李文明庄婕尹弢张琳王传栋王勤
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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