The invention proposes an installation and adjustment system and method for a multi-layer nested X-ray grazing incidence optical lens, and the system comprises a suspension subsystem, a measurement subsystem, a displacement subsystem, a pre-installation supporting device, an optical supporting platform, and a focal plane receiving screen. The method comprises seven steps: preparation, suspension, pre-installation, alignment, measurement, binding, and supporting structure installation. The system and method can greatly improve the installation and adjustment precision, speed and yield of the multi-layer nested X-ray grazing incidence optical lens, achieve no-stress installation and adjustment, improve the optical performance, are easy to implement, is high in universality, is high in installation and adjustment precision, and is high in installation and adjustment efficiency.