The invention provides a 3,350mm-level ellipsoid scalloped segment liquid-filling and forming process and a die thereof. A hydromechanical deep drawing forming mode is adopted. The hydromechanical deep drawing forming mode comprises the following specific steps: a, cleaning: removing sundries on a molded surface of the die and the surface of a blank before liquid filling; b, uniformly smearing an integral molded surface of a male die of the die with lubricating oil; c, filling of a liquid filling chamber: enabling a liquid filling chamber of a female die to be filled with hydraulic oil; d, loading: placing the blank on the female die, adjusting the front and rear positions of the blank to enable the blank to be centered, and adjusting the liquid level of the liquid filling chamber to be parallel and level to the blank; e, paving an annular plastic film on one side, which is in contact with a blank holder, of the blank, and paving a plastic film of which the shape is consistent to that of the blank on the other side, which is in contact with the liquid filling chamber, of the blank; f, hydromechanical deep drawing of a part: controlling the matching relation between the pressure of the liquid-filling chamber and a blank holder force, and carrying out hydromechanical deep drawing forming on the blank; and g, unloading. A one-time liquid-filling forming process is adopted, liquid-filling forming of a 3,350mm-level ellipsoid scalloped segment is realized, a qualified product which meets use requirements is obtained, and the quality of the surface of the part and the precision of the molded surface are improved remarkably.