Application of flavonoid compound to preparation of cholinesterase inhibitor and medicine for preventing and/or treating Alzheimer disease
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- QIQIHAR UNIVERSITY
- Publication Date
- 2021-08-20
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Abstract
Description
technical field
[0001] The invention relates to the technical field of medicine, in particular to the application of a flavonoid compound in the preparation of cholinesterase inhibitors and drugs for preventing and / or treating Alzheimer's disease. Background technique
[0002] Alzheimer's disease (AD) is a chronic neurodegenerative disease that usually begins in late middle age or old age. The severe brain atrophy of AD patients, the senile plaques formed by the aggregation of β-amyloid protein outside the nerve cells and the neurofibrillary tangles formed by the hyperphosphorylation of Tau protein inside the nerve cells, cause neuron damage and death, and the continuous degeneration of neurons leads to the death of patients. Clinically, it shows symptoms such as progressive memory loss, impaired thinking, disorientation, mood and personality changes.
[0003] Due to the complex pathogenesis of AD and the pathogenesis involving a variety of physiological changes in the brai...