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Zirconium oxide implant surface osteogenesis activation promoting treatment method

An implant, zirconia technology, applied in the direction of prosthesis, medical science, coating, etc., can solve the problems of unfavorable protein components and osteoblast adsorption, poor osteogenic induction performance, etc., to promote proliferation and adhesion, Reduce the effect of low toxicity

Pending Publication Date: 2021-08-27
AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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  • Application Information

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Problems solved by technology

A large number of in vivo and in vitro experiments were performed to evaluate the feasibility of zirconia as an implant material, but it was found that the osteoinductive properties of zirconia materials were not as good as those of pure titanium implants
Zirconia is biologically inert and has fewer organic functional groups on the surface, which is not conducive to the adsorption of protein components in blood and osteoblasts, which has become a major problem that limits the wide application of zirconia implants.

Method used

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  • Zirconium oxide implant surface osteogenesis activation promoting treatment method
  • Zirconium oxide implant surface osteogenesis activation promoting treatment method
  • Zirconium oxide implant surface osteogenesis activation promoting treatment method

Examples

Experimental program
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Effect test

Embodiment 1

[0036] A method for preparing a zirconia implant, the process is as follows figure 1 shown, including the following steps:

[0037]Take three zirconia ceramic tiles (5%Y 2 o 3 , 95% ZrO 2 , Zhuhai Yuebojia New Material Co., Ltd., China) were ultrasonically cleaned three times with ethanol and pure water, respectively, and then dried.

[0038] The cleaned and dried tiles were respectively immersed in polyethyleneimine solution (5 mg / ml with deionized water, pH 9.0) for 4 hours, and after incubation, they were air-dried in a ventilated environment at room temperature for 4 hours.

[0039] 1 g of chitosan was dissolved in 100 mL of 1% (v / v) glacial acetic acid solution using a magnetic stirrer to prepare a 1 mg / mL chitosan solution. After soaking the air-dried tiles in the chitosan solution for 4 hours, the air-dried tiles were stored at 4° C. under sterile conditions for future use.

[0040] Prepare a 100 mg / mL chlorogenic acid dimethyl sulfoxide solution, dilute the chloro...

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Abstract

The invention discloses a zirconium oxide implant surface osteogenesis activation promoting treatment method. A zirconium oxide implant comprises a matrix, a coating and active molecules, the matrix is zirconium oxide ceramic, the coating is a polyethyleneimine / chitosan coating attached to the surface of the matrix, and the active molecules are chlorogenic acid grafted on the coating. After the active molecules are grafted on the surface of the zirconium oxide implant by the method, cell adhesion and osteogenic differentiation can be effectively promoted, namely, the zirconium oxide implant has better osteogenic activity promoting capability and has a very good clinical application prospect.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a treatment method for promoting osteogenesis on the surface of a zirconia implant. Background technique [0002] The dark gray color of traditional titanium implants limits its application in the anterior region and in some patients with insufficient peri-implant mucosal thickness. With the deepening of the concept of "metal-free planting", zirconia is considered to be an ideal substitute for titanium due to its good biocompatibility, aesthetic effect and mechanical properties such as high fracture toughness and high flexural strength. A large number of in vivo and in vitro experiments were performed to evaluate the feasibility of zirconia as an implant material, but it was found that the osteoinductive properties of zirconia materials were not as good as those of pure titanium implants. Zirconia is biologically inert and has fewer organic functional groups on the surface, whic...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/50
CPCA61L27/34A61L27/50
Inventor 谢海峰吴桐何峰洪高英
Owner AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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