Construction method of bacterial enteritis model of young rabbits

A technology for bacterial enteritis and construction method, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and plant/algae/fungus/moss components, etc. High, highly standardized, genetically stable effects

Inactive Publication Date: 2021-08-31
SICHUAN ANIMAL SCI ACAD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under natural breeding conditions, non-antibiotic antimicrobial drug evaluation tests have problems such as large randomness and many accidental factors

Method used

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  • Construction method of bacterial enteritis model of young rabbits
  • Construction method of bacterial enteritis model of young rabbits
  • Construction method of bacterial enteritis model of young rabbits

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A traditional Chinese medicine composition comprises the following components: astragalus, coptis, bitterwood, pomegranate peel and Changshan. The mass ratio of astragalus, coptis, bitterwood, pomegranate peel and Changshan is 80:140:180:230:280. The dosage form of the traditional Chinese medicine composition is powder, and the mesh size is 300 mesh.

[0039] The above-mentioned Chinese medicine composition is used for the young rabbit bacterial enteritis model, and its construction method comprises the following steps:

[0040] Get the New Zealand white rabbit that the body weight of 35 days old is 750g, artificially infect (oral) cecum Eimeria oocyst 100 / only, adopt the ration that has added above-mentioned traditional Chinese medicine composition powder to feed simultaneously 2-3 week, The daily feeding amount is 100g / rat, and the addition amount is 800g / 1000kg, and a model of bacterial enteritis in young rabbits is obtained. No antibiotics are added to the diet, an...

Embodiment 2

[0042] A traditional Chinese medicine composition comprises the following components: astragalus, coptis, bitterwood, pomegranate peel and Changshan. The mass ratio of astragalus, coptis, bitterwood, pomegranate peel and Changshan is 100:150:200:250:300. The dosage form of the traditional Chinese medicine composition is powder, and the mesh size is 300 mesh.

[0043] The above-mentioned Chinese medicine composition is used for the young rabbit bacterial enteritis model, and its construction method comprises the following steps:

[0044] Get 35 days old body weight and be the New Zealand white rabbit of 800g, artificially infect (oral) cecum Eimeria oocyst 150 / only, adopt the ration that has added above-mentioned traditional Chinese medicine composition powder to feed simultaneously 2-3 week, The daily feeding amount was 110g / rat, and the addition amount was 1000g / 1000kg, and a young rabbit model of bacterial enteritis was obtained. No antibiotics are added to the diet, and no...

Embodiment 3

[0046] A traditional Chinese medicine composition, comprising the following components: astragalus, coptis, bitterwood, pomegranate peel and Changshan, the mass ratio of astragalus, coptis, bitterwood, pomegranate peel and Changshan is 120:160:220:260:320. The dosage form of the traditional Chinese medicine composition is powder, and the mesh size is 300 mesh.

[0047] The above-mentioned Chinese medicine composition is used for the young rabbit bacterial enteritis model, and its construction method comprises the following steps:

[0048] Get 35 days old body weight and be the New Zealand white rabbit of 900g, artificially infect (oral) cecal Eimeria oocyst 200 / only, adopt the ration that has added above-mentioned traditional Chinese medicine composition powder to feed simultaneously 2-3 week, The daily feeding amount was 120g / rat, and the supplementary amount was 1200g / 1000kg to obtain a young rabbit model of bacterial enteritis. No antibiotics are added to the diet, and no ...

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Abstract

The invention provides a construction method of a bacterial enteritis model of young rabbits. Firstly, a traditional Chinese medicine composition is provided and comprises the following components: astragalus membranaceus, coptis chinensis, picrasma quassioides, pomegranate rind and antifebrile dichroa, and the traditional Chinese medicine composition is applied to construction of the bacterial enteritis model of young rabbits. The construction method of the bacterial enteritis model of the young rabbits comprises the following steps: taking the young rabbits of which the age is 35 days and the weight is 750-900 g, artificially infecting 100-200 Eimeria tenella oocysts per rabbit, and feeding the young rabbits with daily ration with the added traditional Chinese medicine composition powder for 2-3 weeks to obtain the bacterial enteritis model of the young rabbits. The daily ration with the added traditional Chinese medicine composition is used for constructing the enteritis model, stable reproducibility is achieved, the obtained model can be suitable for screening and evaluation of drugs long in treatment course, and the problems that an existing construction method is lack of stable reproducibility, higher in cost, difficult to standardize, only suitable for individual construction and the like are effectively solved.

Description

technical field [0001] The invention belongs to the technical field of establishing an enteritis model, and in particular relates to a method for establishing a young rabbit bacterial enteritis model. Background technique [0002] Animal enteritis mainly includes bacterial enteritis, viral enteritis, parasitic enteritis, nutritional enteropathy, antibiotic-associated enteritis, etc. The purpose of constructing animal enteritis models is mainly to study the pathogenesis of various enteritis and explore new therapeutic drugs. [0003] Animal enteritis models currently mainly include spontaneous animal enteritis models, transgenic animal enteritis models, and induced animal enteritis models. Spontaneous animal enteritis model refers to the natural occurrence of enteritis or enteritis-like diseases in animals. For example, the white hairy top tamarin in South America can naturally produce intestinal inflammation after being housed in cages, but the animals are rare and expensiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/02A23K50/50A23K10/30A23K10/37A61K35/68A61K36/718
CPCA01K67/02A23K50/50A23K10/30A23K10/37A61K35/68A61K36/481A61K36/718A61K36/185A01K2227/107A01K2267/03Y02P60/87
Inventor 任永军杨光友谢晓红季杨雷岷郭志强邝良德郑洁李丛艳张翠霞张翔宇杨超袁定胜唐丽杨锐李钰莹
Owner SICHUAN ANIMAL SCI ACAD
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