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A kind of preparation method and application of high entropy nanozyme

A nanozyme and high-entropy technology, applied in the field of high-entropy nanozyme preparation, achieves the effect of simple method, excellent activity and good medical application prospect

Active Publication Date: 2022-05-13
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As a nanomaterial with catalytic activity similar to natural enzymes, nanozymes have not been reported to prepare high-entropy nanozymes based on high-entropy alloys.

Method used

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  • A kind of preparation method and application of high entropy nanozyme
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  • A kind of preparation method and application of high entropy nanozyme

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preparation example Construction

[0015] The preparation method of the high-entropy nanozyme proposed by the present invention comprises the following steps:

[0016] (1) Five compounds of ruthenium acetylacetonate, rhodium acetylacetonate, palladium acetylacetonate, platinum acetylacetonate and iridium acetylacetonate are poured into the acetylacetone solution, and the mass ratio of the mixed solution is: acetylacetone: ruthenium acetylacetonate: acetylacetonate Rhodium: palladium acetylacetonate: platinum acetylacetonate: iridium acetylacetonate = 1: (0.02~0.001): (0.02~0.001): (0.02~0.001): (0.02~0.001): (0.02~0.001); the utilization power is 250W The mixed solution was ultrasonically treated for 10 minutes. After the compound in the reaction solution was fully dissolved, it was stirred with a magnetic stirrer at a stirring speed of 600 rpm for 10 to 30 minutes to obtain the first solution;

[0017] (2) Add a surfactant in the first solution, and use a power of 250W to ultrasonically treat the mixed solutio...

Embodiment 1

[0029] (1) Five compounds of ruthenium acetylacetonate, rhodium acetylacetonate, palladium acetylacetonate, platinum acetylacetonate and iridium acetylacetonate are poured into the acetylacetone solution, and the mass ratio of the mixed solution is acetylacetonate: ruthenium acetylacetonate: rhodium acetylacetonate : palladium acetylacetonate: platinum acetylacetonate: iridium acetylacetonate = 1:0.02:0.02:0.02:0.02:0.02. Ultrasonic treatment of the mixed solution with a power of 250W for 10 minutes, after the compound in the reaction solution is fully dissolved, stirred for 10 minutes with a magnetic stirrer at a stirring speed of 600 rpm to obtain the first solution;

[0030] (2) Add the surfactant cetyltrimethylammonium chloride in the first solution, and use a power of 250W to ultrasonically treat the mixed solution for 10 minutes. After the surfactant in the reaction solution is fully dissolved, the stirring speed Stir with a magnetic stirrer at 600 rpm for 10 minutes so ...

Embodiment 2

[0034](1) Five compounds of ruthenium acetylacetonate, rhodium acetylacetonate, palladium acetylacetonate, platinum acetylacetonate and iridium acetylacetonate are poured into the acetylacetone solution, and the mass ratio of the mixed solution is acetylacetonate: ruthenium acetylacetonate: rhodium acetylacetonate : palladium acetylacetonate: platinum acetylacetonate: iridium acetylacetonate = 1:0.001:0.001:0.001:0.001:0.001. Ultrasonic treatment of the mixed solution with a power of 250W for 10 minutes, after the compound in the reaction solution is fully dissolved, stirred for 10 minutes with a magnetic stirrer at a stirring speed of 600 rpm to obtain the first solution;

[0035] (2) Add the surfactant cetyltrimethylammonium chloride in the first solution, and use a power of 250W to ultrasonically treat the mixed solution for 10 minutes. After the surfactant in the reaction solution is fully dissolved, the stirring speed Stir with a magnetic stirrer at 600 rpm for 10 minutes...

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Abstract

The invention belongs to the technical field of functional materials, and in particular relates to a preparation method and application of a high-entropy nanozyme. The method uses ruthenium acetylacetonate, rhodium acetylacetonate, palladium acetylacetonate, platinum acetylacetonate, iridium acetylacetonate and acetylacetonate as raw materials. In a strong alkaline solvent, polymer precursors are generated through intermolecular polymerization reactions, and high-entropy nanozymes are obtained by means of calcination. The invention has the advantages of simple method, small and uniform nanoparticle size, adjustable nanoparticle density and the like, and no redundant solvent is added to the reaction system, thereby realizing the requirement of green environmental protection. The preparation method of the high-entropy nanomaterial proposed by the present invention can promote the further development of related research on nanozymes and high-entropy alloys. The high-entropy nanomaterial prepared by the method has excellent peroxidase-like activity and can catalyze hydrogen peroxide to generate hydroxyl radicals with strong cytotoxicity, so it has good medical application prospects.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and in particular relates to a preparation method and application of a high-entropy nanozyme. Background technique [0002] Metal alloy materials are ubiquitous in our daily life and have played an extremely important role in the process of human development. In recent years, a new alloy design concept has broken through the traditional thinking. Researchers mixed five or more elements in a (nearly) equal atomic ratio to obtain a single-phase solid solution alloy with a simple crystal structure. It is believed that the maximum configuration entropy achieved through compositional regulation in the multi-component system played an important role in stabilizing the structure of the new alloy, so the researchers named it "high-entropy alloy". High-entropy alloys, referred to as HEAs, are defined as alloys formed of five or more equal or approximately equal amounts of metals. That is, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J23/46B01J35/02A61K33/24A61K33/243A61P35/00B82Y30/00B82Y40/00
CPCB01J23/468B01J35/0013B01J35/023B82Y30/00B82Y40/00A61K33/243A61K33/24A61P35/00A61K2300/00
Inventor 梁琼麟艾永建
Owner TSINGHUA UNIV
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