Antiviral oral spray and preparation method thereof

An oral spray and anti-virus technology, which is applied in the direction of anti-viral agents, anti-inflammatory agents, anti-fungal agents, etc., can solve the problem of single product form, achieve convenient use, prevent oral inflammation and respiratory epithelial mucosa damage, and kill and the effect of suppressing viruses in the oral cavity

Pending Publication Date: 2021-09-03
JIANGXI DESHANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Moreover, among the disinfection products in the current market, they are mostly sold in the form of liniment, water, disinfectant, and oral liquid. The product form is single, and the form of oral spray is still less. Sprays and powder mist are sought after by the market

Method used

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  • Antiviral oral spray and preparation method thereof
  • Antiviral oral spray and preparation method thereof
  • Antiviral oral spray and preparation method thereof

Examples

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preparation example Construction

[0043] Its preparation method comprises the following method steps:

[0044] 1) Extraction, filtering,

[0045] Mix the honeysuckle, forsythia, licorice, Daqingye, wild chrysanthemum, Banlangen, Houttuynia cordata, Artemisia annua, Anemarrhena, and northern bean root in proportions by mass, and then soak in purified water for 1-10 hours. According to the ratio of material to liquid mass ratio of 1:10-15, the extraction is carried out by mixing and heating, and the extraction temperature is controlled to be 50-70 ° C and the time is 1-1.5 hours. The extracted filtrate is mixed to obtain a mixed extract;

[0046] 2) Concentrate under reduced pressure,

[0047] The step 1) mixed extract is placed in a vacuum concentrating device, and vacuum concentrating treatment is carried out. mixed concentrate;

[0048] 3) Alcohol precipitation to remove impurities,

[0049] Step 2) the mixed concentrated solution is subjected to alcohol precipitation treatment under the condition of con...

Embodiment 1

[0305] An antiviral oral spray of the present embodiment is composed of the following quality components, honeysuckle 18, skullcap 18, forsythia 18, Daqingye 16, licorice 8, Bupleurum 6, wild chrysanthemum 5-10, isatis 6, Sucralose 1.5, Menthol 0.5, Houttuynia cordata 5, 95% benzalkonium bromide 0.55, Ethanol 500, Artemisia annua 5, Anemarrhena 3, Beidougen 0.5, purified water or water for injection to add to 1000 units Mass units such as grams.

[0306] The preparation method of the antiviral oral spray of the present invention adopts a semi-biomimetic method for extraction, which comprises the following method steps:

[0307] 1) Extraction, filtering,

[0308] The honeysuckle, forsythia, licorice, Daqingye, wild chrysanthemum, Banlangen, Houttuynia cordata, Artemisia annua, Anemarrhena, and northern bean root of the above-mentioned mass proportions are mixed into a mixture and soaked in purified water for 1-10 hours , and then extract by mixing and heating according to the...

Embodiment 2

[0341] An antiviral oral spray of the present embodiment is composed of the following quality components: 20 honeysuckle, 20 skullcap, 20 forsythia, 15 daqingye, 10 licorice, 10 bupleurum, 8 wild chrysanthemum, 6 isatis, triclosan Sucrose 1.5, menthol 0.5, Houttuynia cordata 8, 95% benzalkonium bromide 0.55, ethanol 500, purified water or water for injection supplemented to 1000 units as mass units such as grams;

[0342] The preparation method of the antiviral oral spray of the present invention adopts a semi-biomimetic method for extraction, which comprises the following method steps:

[0343] 1) Extraction, filtering,

[0344] The honeysuckle, forsythia, licorice, Daqingye, wild chrysanthemum, Banlangen, Houttuynia cordata, Artemisia annua, Anemarrhena, and northern bean root of the above-mentioned mass proportions are mixed into a mixture and soaked in purified water for 1-10 hours , and then extract by mixing and heating according to the ratio of material to liquid mass ...

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Abstract

The invention discloses an antiviral oral spray and a preparation method thereof. The antiviral oral spray is prepared from the following components in parts by mass: 13 to 25 parts of honeysuckle flower, 13 to 25 parts of radix scutellariae, 13 to 25 parts of fructus forsythiae, 12 to 22 parts of folium isatidis, 6 to 11 parts of liquorice root, 5 to 10 parts of radix bupleuri, 5 to 10 parts of flos chrysanthemi indici, 5 to 10 parts of radix isatidis, 0.2 to 0.8 part of menthol, 5 to 10 parts of herba houttuyniae, 1.0 to 2.0 parts of sucralose, 0.25 to 0.85 part of 95% benzalkonium bromide, 400 to 600 parts of ethyl alcohol, and the balance purified water, wherein the total amount is 1000 parts. The antiviral oral spray has the advantages that the functions of killing and inhibiting viruses in oral cavity are realized, and the killing rate on staphylococcus aureus and pseudomonas aeruginosa reaches 99.999% within 5min; the average killing logarithmic time on candida albicans is longer than 4.00min, and the killing rate is also higher than 99.99%; and the oral inflammation and respiratory tract epithelial mucosa injury caused by virus replication can be prevented, the spreading of droplets with viruses is effectively prevented, and the function of preventing the spreading and diffusion of novel coronavirus is effectively realized.

Description

Technical field: [0001] The invention relates to the field of Chinese herbal medicine preparations, mainly to the field of preventive and antiviral oral sprays prepared by using Chinese herbal medicines, in particular to an antiviral oral spray and a preparation method. Background technique: [0002] Chinese herbal medicine is an important part of traditional medicine in our country, and it is also a medical treasure of our country and human society. Make full use of Chinese herbal medicine to maximize the utilization of Chinese herbal medicine. Practice has shown that Chinese herbal medicine has played an important role in the prevention and control of the new coronavirus. [0003] For the transmission route of the new coronavirus: droplet transmission is one of the main transmission routes, how to prepare an oral spray with preventive, disinfecting and antiviral functions. It can effectively kill and prevent viruses in the oral cavity. Therefore, how to choose the compon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K36/78A61K36/855A61P31/14A61P1/02A61P29/00A61P11/00A61P31/04A61P31/10A61P31/02A61K31/045
CPCA61K9/12A61K9/006A61K36/355A61K36/539A61K36/634A61K36/855A61K36/704A61K36/315A61K36/195A61K36/484A61K36/233A61K36/287A61K31/045A61K36/78A61K47/26A61P31/14A61P1/02A61P29/00A61P11/00A61P31/04A61P31/10A61P31/02A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/333A61K2300/00
Inventor 谢作桦周彦如盛文胜陈琦曹国义
Owner JIANGXI DESHANG PHARMA
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