A bioactive degradable magnesium alloy guided bone regeneration membrane and its dense hole processing method

A technology that guides bone regeneration and bioactivity. It is applied in metal processing equipment, tissue regeneration, and manufacturing tools. It can solve problems such as lack of density distribution, increased processing difficulty, and unfavorable bone defect repair, so as to improve the treatment effect. The hole circumference is smooth and the hole quality is good

Active Publication Date: 2022-02-08
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a bioactive degradable magnesium alloy guided bone regeneration membrane, which overcomes the design of the barrier membrane in the prior art because the size of the through hole will affect the migration of soft tissue cells and the degradation rate of the barrier membrane. Too large pore size will cause soft tissue cells to grow into the bone defect area, hindering bone tissue repair; too small pore size will cause the gas generated by the degradation of the barrier membrane to be unable to be discharged smoothly, and the processing difficulty will increase; and the designed through holes are basically arranged in the entire barrier membrane In general, there is no rule of density distribution, which leads to rapid degradation of the material between the through holes of the barrier membrane, and the interconnection of the through holes makes the entire barrier membrane lose its mechanical support prematurely, which is not conducive to the repair of bone defect areas and other technical problems

Method used

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  • A bioactive degradable magnesium alloy guided bone regeneration membrane and its dense hole processing method
  • A bioactive degradable magnesium alloy guided bone regeneration membrane and its dense hole processing method
  • A bioactive degradable magnesium alloy guided bone regeneration membrane and its dense hole processing method

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Embodiment 1

[0031] In order to facilitate the pre-experiment in rats and evaluate the effect of the barrier membrane on soft tissue ingrowth and the degree of degradation, the barrier membrane model was simplified as a disc with a diameter of 8 mm and a thickness of 0.08-0.30 mm with a through-hole area. The dense holes are all distributed in a circular area with a standard diameter of 0.5mm, and the diameter of the dense holes is 0.2mm. The distribution of the dense holes is as follows: image 3 Shown (unit: mm). Dense hole specifications and distribution rules can be directly used for figure 1 oral barrier membranes.

Embodiment 2

[0033] Others are identical with embodiment 1, and difference is that the diameter of dense hole is 0.1mm, and the distribution of dense hole is as follows Figure 4 Shown (unit: mm)

Embodiment 3

[0035] Others are identical with embodiment 1, and difference is that the diameter of dense hole is 0.05mm, and the distribution of dense hole is as follows Figure 5 Shown (unit: mm)

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Abstract

The invention relates to a bioactive degradable magnesium alloy guided bone regeneration membrane and a processing method for dense pores thereof, comprising: a barrier membrane whose shape fits the bone tissue around the defect area, the barrier membrane is divided into upper and lower parts, and the upper and lower parts of the barrier membrane It is designed to have a skeleton structure area and a regularly arranged through hole area. The arrangement rule of the through hole is dense and dense. There are no through holes at the skeleton structure, and the through hole area is a plurality of 0.5‑5mm circular areas. In the above A number of dense holes less than or equal to 0.2mm are evenly distributed in the circular area, and the spacing of the dense holes is adjusted according to the corrosion rate of the actual material used and the required corrosion effect. The barrier film also includes blind holes with a depth of 0.05mm-0.25mm, and drugs are loaded in the blind holes. The through holes of the present invention can discharge degraded gas, penetrate body fluids, nutrients, and red blood cells, and hinder the penetration of soft tissue cells; the dense holes in the through hole area mainly serve to prevent early soft tissue growth, and at the same time, the implanted At the same time, it can degrade, release magnesium ions, and play an osteogenic role; the barrier membrane is designed with a skeleton structure, and there are no through holes in the skeleton structure, which can be modified and degraded slowly to maintain the mechanical support of the barrier membrane in the process of bone repair. The invention can solve the technical problem that the material between the through holes of the existing barrier membrane is rapidly degraded, and the entire barrier membrane loses mechanical support prematurely after the through holes are connected to each other, which is not conducive to the repair of the bone defect area.

Description

technical field [0001] The invention belongs to the technical field of oral medical devices, and in particular relates to a bioactive degradable magnesium alloy guiding bone regeneration film and a processing method for dense pores thereof. Background technique [0002] Periodontal disease is currently one of the most common oral diseases, and the number of patients continues to grow. Periodontal disease can lead to damage to periodontal ligament and gingival tissue, and in severe cases, it may lead to tooth loss and alveolar bone resorption in patients, especially elderly patients. If the amount of alveolar bone is insufficient, operations such as oral implants cannot be performed. Therefore, in this case, the alveolar bone defect area needs to be reconstructed first. With the development of degradable medical metal materials and medical technology, guided bone regeneration (GBR) and guided tissue regeneration (GTR) technologies have become the hotspots of bone augmentatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/50A61L27/58A61L27/54A61L27/04B23K26/0622
CPCA61L27/56A61L27/50A61L27/58A61L27/54A61L27/047B23K26/0624A61L2430/02A61L2300/102A61L2300/412A61L2300/41A61L2300/602
Inventor 郭传瑸韩建民谭成文李介博郭雨竹刘冠旗陈良伟
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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