Sulfonium salt cationic polymer with antibacterial property, preparation method and application

Abstract

The invention provides a sulfonium salt cationic polymer with antibacterial performance, a preparation method and application. The sulfonium salt cationic polymer comprises sulfonium salt cationic repeating units. Compared with the prior art, the sulfonium salt cationic polymer with antibacterial performance has the following beneficial effects that the sulfonium salt cationic polymer containing a sulfonium salt structure in a main chain is designed, sulfonium salt cations in a molecular structure interact with an electronegative structure on the surface of a bacterial cell membrane, and other hydrophilic and hydrophobic groups in the molecular structure are matched to act on the bacterial cell membrane; bacterial cell membranes are disintegrated, so that bacteria are killed; the polymer has the advantages of high sterilization speed, excellent antibacterial effect, high sterilization activity and broad-spectrum antibacterial performance, and has the sterilization rate of 99.9% on gram-positive bacteria and gram-negative bacteria when the polymer concentration is 100 mug / mL. Besides, the sulfonium salt cationic polymer prepared according to the invention has excellent biocompatibility and low toxicity, and when the polymer concentration is greater than or equal to 5300 mug / mL, the red blood cell hemolysis rate can still be less than or equal to 50%.

Description

technical field [0001] The invention belongs to the field of antibacterial polymers, and in particular relates to a sulfonium salt cationic polymer with antibacterial properties, a preparation method and an application. Background technique [0002] Bacteria are common pathogens in infectious diseases and foodborne diseases, especially in areas where medical resources are scarce and public health is relatively poor. Bacterial infection has become one of the main health threats in recent years. Currently, the main treatment for the problem of bacterial infections is the use of antibiotics. However, due to the abuse of antibiotics in recent years, drug-resistant bacterial infections have been increasing worldwide. Therefore, it is imperative to develop new and efficient broad-spectrum antibacterial materials. [0003] Antibacterial materials refer to the general term for materials that can kill or inhibit the growth of microorganisms. Generally, they can be divided into the ...

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Problems solved by technology

[0004] Researchers began to try to synthesize sulfonium salt polymers as antibacterial products, such as the synthesis of 4-vinylbenzyl tetramethylene sulfonium tetrafluoroborate polymers by Kanazaw et al. The results showed that this type of polymers was only effective against aureus Gram-positive bacteria including cocci have higher antibacterial activity, while Gram-negative bacteria including Escherichia coli have lower antibacterial activity and poor broad-spectrum

Although the tris(n-alkylphenyl)sulfonium salts (TAPSs) synthesized by Hirayama have high antibacterial activity, their acute toxicity and skin irritation are relatively strong.

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