Unlock instant, AI-driven research and patent intelligence for your innovation.

Composition for inhibiting digestive tract peristalsis and digestive tract peristalsis inhibitor

A composition and digestive tract technology, applied in the field of digestive tract peristalsis inhibitors and compositions for inhibiting digestive tract peristalsis, can solve the problem of low solubility of menthol

Active Publication Date: 2021-09-24
SHANDONG WEIGAO HONGRUI MEDICAL TECH CO LTD
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The solubility of menthol in water is very low, and the solubility of menthol in water is increased by adding a surfactant system. As the temperature changes, especially under low temperature conditions, menthol crystallizes out of water, and after freezing, it precipitates from the solution Menthol can no longer be dissolved by placing the solution at room temperature, which affects the use

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition for inhibiting digestive tract peristalsis and digestive tract peristalsis inhibitor
  • Composition for inhibiting digestive tract peristalsis and digestive tract peristalsis inhibitor
  • Composition for inhibiting digestive tract peristalsis and digestive tract peristalsis inhibitor

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] The present invention also provides a preparation method of the digestive tract motility inhibitor, comprising the following steps:

[0045] (1) Add silicon dioxide into simethicone, stir evenly, and heat at 150-200°C for 2-8 hours to obtain a defoamer;

[0046] (2) L-menthol, defoamer, solubilizer, preservative and water are heated and stirred to complete the dispersion and dissolution process;

[0047](3) adding a pH regulator to the solution prepared in step (2), adjusting the pH of the solution to 3.0 to 7.0 to obtain an inhibitor of digestive tract motility;

[0048] In some embodiments, the heating temperature in step (2) is 30-55°C.

[0049] In some embodiments, the heating temperature in step (2) is 40-50°C.

[0050] The present invention does not contain fats or oils. Aqueous menthol solutions can be made very stable by solubilizing menthol with polyoxyethylene ether hydrogenated castor oil. By preparing the process at a lower temperature, the volatilizatio...

Embodiment 1～8

[0054]

[0055]

[0056] Including the following steps:

[0057] (1) Add silicon dioxide into simethicone, stir evenly, and heat at 150-200°C for 2-8 hours to obtain a defoamer;

[0058] (2) L-menthol, defoamer, solubilizer, preservative and water are heated (30-55°C) and stirred to complete the dispersion and dissolution process;

[0059] (3) Adding a pH adjusting agent to the solution prepared in step (2), adjusting the pH of the solution to 3.0-7.0, and obtaining an inhibitor of digestive tract motility.

Embodiment 1

[0104] Experimental animal pigs were randomly divided into 8 groups. Enter the stomach through the endoscope, observe and record the number of peristalsis that affects the endoscopic observation within ten minutes. Then use the endoscope spray tube to place the embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5,

[0105]Embodiment 6, embodiment 7, embodiment 8 preparations are sprayed on pig gastric antrum position, and each sample spraying amount is 20ml, then record the number of times of peristalsis that affects endoscopic observation in every ten minutes after sample spraying and whether after sample spraying The generation of foam affects the observation, and the total observation time is 60 minutes.

[0106] Table 8

[0107]

[0108] From Table 5, it is obvious that all the preparations obtained in the examples of the present invention have good gastric motility inhibitory properties. Before spraying the preparations obtained in the examples of the...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention relates to the field of pharmaceutical preparations, in particular to a composition for inhibiting digestive tract peristalsis and a digestive tract peristalsis inhibitor. The composition for inhibiting digestive tract peristalsis and the digestive tract peristalsis inhibitor do not contain fat or oil. Polyoxyethylene ether hydrogenated castor oil is used for solubilizing menthol, so that the menthol aqueous solution is very stable. Through a preparation process at a relatively low temperature, volatilization of menthol is reduced, and the stability of the product is improved.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a composition for inhibiting digestive tract peristalsis and an inhibitor of digestive tract peristalsis. Background technique [0002] Scoronine is one of the commonly used antispasmodics before general gastroscopy. Scopolamine is an antimuscarinic drug with a similar pathway to atropine. It has peripheral anticholinergic effect and can block parasympathetic nerves. It can be used in gastroscopy to relieve smooth muscle spasm, inhibit gland secretion, and significantly shorten the operation time of gastroscopy. , to reduce the patient's pain and postoperative reaction, and to obtain higher quality gastroscopy results. [0003] However, scotronine is contraindicated in patients with glaucoma, prostatic hypertrophy, myasthenia gravis, severe heart disease, organic pyloric stenosis, gastrointestinal obstructive disease, reflux esophagitis, ulcerative colitis or toxic meg...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/44A61K31/045A61P1/06
CPCA61K47/44A61K31/045A61P1/06
Inventor 杜武华林栋青赵素霞黄显峰王清山刁盈盈邱新林李鹏娥尹翠竹
Owner SHANDONG WEIGAO HONGRUI MEDICAL TECH CO LTD