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Titanium-based implant for promoting synostosis, preparation method and application thereof

A technology of implant and osseointegration, applied in the direction of prosthesis, pharmaceutical formula, coating, etc., to achieve the effect of good hydrophilicity, increased proliferative ability, and huge commercial value

Active Publication Date: 2021-09-28
DENTAL HOSPITAL SHANXI MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, there is no report on loading bovine pancreatic β cell exosomes on the surface of the implant to form a Ti-Exo-TiO2 composite structure to improve the osseointegration rate of the implant

Method used

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  • Titanium-based implant for promoting synostosis, preparation method and application thereof
  • Titanium-based implant for promoting synostosis, preparation method and application thereof
  • Titanium-based implant for promoting synostosis, preparation method and application thereof

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Embodiment 1

[0038] Preparation and performance of embodiment 1 titanium-based implant

[0039] 1.1 Preparation of exosomes from bovine pancreatic β cells

[0040] ① Isolation and culture of bovine pancreatic β cells

[0041] a. Take the pancreas from the slaughterhouse, store it in an ice box at low temperature, and send it to the biosafety laboratory within 6 hours.

[0042] b. Under a sterile environment, after washing the bovine pancreas with 75% alcohol three times, cut out a bovine pancreas weighing 10 g and soak it in 20 mL of standard phosphate balanced salt buffer solution (pH=7.4).

[0043] c. Place the washed pancreas in a 6cm petri dish, cut it into pieces, add 5mL of type IV collagenase, and digest at 37°C for 45min. During this period, pipette the sample several times with a 1mL pipette tip, and place the above sample on a constant temperature incubation shaker for 37 Shake at 30 rpm for 10 minutes at ℃ to make the enzyme fully contact with the sample to achieve the best di...

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Abstract

The invention discloses a titanium-based implant for promoting synostosis, a preparation method and application thereof, and belongs to the field of biological implants. The preparation method includes the steps of loading bovine pancreas beta cell exosomes on the surface of a pure titanium-based implant by using a chemical fixation method, and then depositing a TiO2 nano layered film on the surface of an Exo-Ti implant by using an atomic layer deposition technology to form a Ti-Exo-TiO2 sandwich composite structure, so as to develop and prepare the titanium-based implant loaded with the bovine pancreas beta cell exosomes. A Ti-Exo-TiO2 nano layered film is uniform and highly conformal, and has better hydrophilicity, antibacterial property and corrosion resistance. According to the titanium-based implant, the proliferation and osteogenic differentiation capacity of bone marrow mesenchymal stem cells can be remarkably improved, the osteogenic speed of the surface of the implant is increased, and the bone-implant contact rate and the removal torque of the implant are remarkably improved. The titanium-based implant for promoting synostosis is suitable for industrial popularization and application, and a new product is provided for the field of medical implant human body materials.

Description

technical field [0001] The invention relates to the field of biological implants, in particular to a titanium-based implant for promoting osseointegration, its preparation method and application. Background technique [0002] Dental implants have become the preferred method of restoration for missing or missing dentition. At present, a major problem facing dental implants is that due to the lack of initial stability of the implants, continuous micro-movements cause osseointegration failures, which eventually lead to early loss of the implants. Among elderly people with osteoporosis, diabetes, periodontal disease, and smokers, the osseointegration rate of implants caused by various systemic diseases is reduced, which has become the main risk of artificial dental implant failure. Therefore, how to improve the osseointegration rate of implants and expand the indications of dental implants is still an urgent problem to be solved in the treatment of artificial dental implants. ...

Claims

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Application Information

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IPC IPC(8): A61L27/38A61L27/06A61L27/30A61L27/50A61L27/54C23C16/455C23C16/40
CPCA61L27/3804A61L27/3865A61L27/06A61L27/306A61L27/50A61L27/54C23C16/45555C23C16/405A61L2430/12A61L2300/412A61L2400/18A61L2420/02A61L2400/12
Inventor 王兴李晖菲赵彬田春瑞
Owner DENTAL HOSPITAL SHANXI MEDICAL UNIV
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