Preparation method of liposome containing glycyrrhiza inflata root extract and madecassoside

A technology of madecassoside and licorice root, which is applied in the field of liposome preparation containing licorice root extract and madecassoside, can solve the problems of function and application limitation, low bioavailability and the like, and achieves The effect of improving bioavailability

Active Publication Date: 2021-10-01
杭州花凝香生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because it is a polar macromolecular substance, it is not easy to reach the lesion through the skin epidermis, and its bioavailability is low, so its effect and application are limited.
[0005] Therefore, the existing technology has the problem of low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1. The preparation method of liposome containing licorice root extract and madecassoside comprises the following steps:

[0034] A. Add the root extract of Glycyrrhiza inflata to 1,3-propanediol, and stir and dissolve at 30-70°C to obtain solution A;

[0035] B. Add water to hydroxypropyl-β-cyclodextrin, stir and dissolve at 30-70°C, and add solution A under stirring condition, and stir at 30-70°C for 2-8 hours to obtain swelling Licorice Root Extract / Hydroxypropyl-β-cyclodextrin inclusion complex aqueous solution;

[0036] C. Use a centrifugal spray dryer to dry the licorice root extract / hydroxypropyl-β-cyclodextrin inclusion compound aqueous solution to obtain the licorice root extract / hydroxypropyl-β-cyclodextrin inclusion complex compound;

[0037] D. Add lecithin and cholesterol to caprylic / capric triglyceride, stir and dissolve at 70-90°C to obtain an oil phase;

[0038] E. Add licorice root extract / hydroxypropyl-β-cyclodextrin inclusion compound and m...

Embodiment 2

[0048] Example 2. The preparation method of liposome containing licorice root extract and madecassoside comprises the following steps:

[0049] A. Add 5 g of Glycyrrhiza inflata root extract to 20 g of 1,3-propanediol, and stir and dissolve at 50° C. to obtain solution A.

[0050] B. Add 10g of water to 10g of hydroxypropyl-β-cyclodextrin, stir and dissolve at 50°C, and add solution A under stirring conditions, and stir at 50°C for 4 hours to obtain Glycyrrhiza inflata Root extract / hydroxypropyl-β-cyclodextrin inclusion complex aqueous solution;

[0051] C. Use a centrifugal spray dryer to dry the licorice root extract / hydroxypropyl-β-cyclodextrin inclusion compound aqueous solution, the air inlet temperature is 160°C, and the pump speed is 6.3r min -1 , to obtain the root extract / hydroxypropyl-β-cyclodextrin inclusion complex of Glycyrrhiza inflata;

[0052] D. Add 5g of lecithin and 1g of cholesterol into 20g of caprylic acid / capric triglyceride, stir and dissolve at 80°C...

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Abstract

The invention discloses a preparation method of lipidosome containing a glycyrrhiza inflata root extract and madecassoside, and the method comprises the following steps: A, adding the glycyrrhiza inflata root extract into 1, 3-propylene glycol to obtain a dissolving solution A; B, adding water and the dissolving solution A into hydroxypropyl-beta-cyclodextrin, and performing stirring to obtain a glycyrrhiza inflate root extract/hydroxypropyl-beta-cyclodextrin inclusion compound aqueous solution; C, drying the aqueous solution of the glycyrrhiza inflata root extract/hydroxypropyl-beta-cyclodextrin inclusion compound to obtain a glycyrrhiza inflata root extract/hydroxypropyl-beta-cyclodextrin inclusion compound; D, adding lecithin and cholesterol into caprylic/capric triglyceride to obtain an oil phase; E, adding the glycyrrhiza inflata root extract/hydroxypropyl-beta-cyclodextrin inclusion compound and madecassoside into water to obtain a water phase; F, adding the oil phase into the water phase, and homogenizing and circulating by using a high-pressure homogenizer to obtain the liposome containing the glycyrrhiza inflata root extract and madecassoside. The preparation method has the characteristic that the bioavailability can be effectively improved.

Description

technical field [0001] The invention relates to a preparation method of licorice root extract / cyclodextrin, in particular to a preparation method of liposome containing licorice root extract and madecassoside. Background technique [0002] Inflammation is an adaptive response produced by the body after being injured or harmful stimuli, and it is closely related to the occurrence and development of many diseases. Skin inflammation is one of the common inflammatory problems. The skin is an important protective layer to protect the human body from external damage and stimuli. When external stimuli cause damage to the human body, the immune system of the skin will initiate signals to promote inflammatory factors such as arachidonic acid. ﹑The overexpression of interleukin and other inflammatory factors and histamine causes blood flow to accelerate and cell permeability to increase, leading to symptoms such as skin tightness and redness, itching, desquamation, and even burning an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K36/484A61K47/14A61K47/24A61K47/28A61K47/69A61P29/00A61P17/02A61K31/7024
CPCA61K9/1277A61K47/6951A61K36/484A61K31/7024A61K47/28A61K47/24A61K47/14A61P29/00A61P17/02A61K2300/00
Inventor 张大勇毕永贤杜雨涵周浩淼李昊刘金俊朱秀洁
Owner 杭州花凝香生物科技有限公司
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