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Application of a traditional Chinese medicine composition in the preparation of medicines for alleviating cardiotoxicity caused by anticancer drugs

A technology of cardiotoxicity and composition, applied in the field of medicine, can solve problems such as deficiency, achieve the effects of eliminating toxic side effects, reducing myocardial cell swelling or vacuolation, and maintaining normal structure and function

Active Publication Date: 2022-04-05
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is a lack of drugs for alleviating the toxic and side effects of tumor chemotherapy drugs as a whole.

Method used

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  • Application of a traditional Chinese medicine composition in the preparation of medicines for alleviating cardiotoxicity caused by anticancer drugs
  • Application of a traditional Chinese medicine composition in the preparation of medicines for alleviating cardiotoxicity caused by anticancer drugs
  • Application of a traditional Chinese medicine composition in the preparation of medicines for alleviating cardiotoxicity caused by anticancer drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1 Chinese medicine composition and its preparation

[0053] Present embodiment provides seven kinds of Chinese medicine compositions:

[0054] 1. Composition of raw materials

[0055] Chinese medicine composition 1:

[0056] Prepare 20 parts of aconite, 10 parts of epimedium, 10 parts of dried ginger, 10 parts of licorice, 6 parts of ginseng, 6 parts of salvia miltiorrhiza, 6 parts of knotweed, 6 parts of poria cocos, 3 parts of Phellodendron phellodendri, and 3 parts of skullcap.

[0057] Chinese medicine composition 2:

[0058] Prepare 20 parts of aconite, 14 parts of epimedium, 15 parts of dried ginger, 10 parts of licorice, 10 parts of ginseng, 12 parts of poria cocos, 6 parts of knotweed, 10 parts of salvia miltiorrhiza, 5 parts of Phellodendron phellodendri, and 3 parts of skullcap.

[0059] Chinese medicine composition 3:

[0060] Prepare 30 parts of aconite, 15 parts of epimedium, 10 parts of dried ginger, 15 parts of licorice, 6 parts of ginseng,...

Embodiment 2

[0076] The attenuation effect of embodiment 2 traditional Chinese medicine composition to tumor chemotherapeutic drug poisoning mice

[0077] 1. Experimental method

[0078] 1.1 Animal grouping and handling

[0079] Kunming mice, 8-9 weeks old, weighing 25±3g. Purchased from the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine, certificate number: SCXK (Guangdong) 2018-0001.

[0080] They were adaptively raised in an SPF animal room for one week, and divided into random groups, with 8 animals in each group (half male and half male). Weigh the body weight before administration every day, and observe and record the general condition.

[0081] Normal control group: intragastric administration of pure water, 0.3mL / time, administration from day 1 to day 7, once a day, normal saline (N.S.) intraperitoneal injection of 0.3mL / time on day 1-4, 1 1 time a day.

[0082] Tumor chemotherapeutic drug group: intragastric administration of pure water, 0....

Embodiment 3

[0119] Example 3 The Attenuation of Chinese Medicine Compositions on Cardiotoxicity in Mice Caused by Tumor Chemotherapy Drugs

[0120] 1.1 Animal grouping and handling

[0121] Kunming mice, male, 8-9 weeks old, 10 in each group, recorded body weight before administration every day. The Chinese medicine composition 1-7 prepared in Example 1 was used for experimentation.

[0122] Animals were grouped and handled as follows:

[0123] Normal group: intragastric administration of pure water, 0.3mL / time / d, administration from day 1 to day 13, intraperitoneal injection of N.S. 0.3mL / time / d on day 8-11.

[0124] Tumor chemotherapeutic drug group: intragastric administration of pure water, 0.3 mL / time / d, administration from day 1 to day 13, intraperitoneal injection of CTX on day 8-11 (dosing regimen is the same as experiment 1).

[0125] Low-dose group of traditional Chinese medicine composition: intragastric administration of 0.65 g / kg / d (4.5 times the human dose) of the traditi...

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Abstract

The invention discloses the application of a traditional Chinese medicine composition in the preparation of medicines for reducing the toxicity of anticancer drugs. The traditional Chinese medicine composition is composed of the following components in parts by weight: 20-30 parts of prepared aconite, 10-15 parts of epimedium 10-15 parts of dried ginger, 10-15 parts of licorice, 6-12 parts of ginseng, 6-12 parts of salvia miltiorrhiza, 6-12 parts of knotweed, 6-12 parts of Poria cocos, 3-5 parts of Phellodendron phellodendri, and 2-4 parts of skullcap. The traditional Chinese medicine composition can be prepared into various pharmaceutically acceptable dosage forms, can eliminate or effectively reduce the toxic and side effects caused by tumor chemotherapy drugs, especially cardiotoxicity, and provides a new drug option for clinically reducing the cardiotoxicity of tumor chemotherapy drugs ; and it can also significantly enhance the efficacy of anticancer drugs, and also provides a new synergistic drug for anticancer drugs.

Description

technical field [0001] The invention relates to the technical field of medicine, and more specifically relates to the application of a traditional Chinese medicine composition in the preparation of medicines for alleviating cardiotoxicity caused by anticancer drugs. Background technique [0002] Cancer (malignant tumor) seriously endangers human health. Anticancer drugs (small molecule chemical drugs and antibody drugs) are the basic means of treating cancer by inhibiting the growth of tumor cells. However, the side effects caused by anticancer drug treatment, such as gastrointestinal adverse reactions, bone marrow suppression, and damage to important organs (heart, liver, kidney, lung), etc., also cause additional damage to the body and mind of cancer patients. Among them, cardiotoxicity is a common problem of side effects of anticancer drugs. Some commonly used cancer chemotherapy drugs are cardiotoxic, which can cause myocardial cell death and fibrosis, cardiomyopathy, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P9/00A61P9/04A61P9/06A61P35/00G01N30/02G01N30/90
CPCA61K36/714A61K36/296A61K36/9068A61K36/484A61K36/258A61K36/537A61K36/704A61K36/076A61K36/756A61K36/539A61P35/00A61P9/00A61P9/06A61P9/04G01N30/02G01N30/90A61K2236/331A61K2236/55A61K2300/00
Inventor 胡英杰钟鹏程沈小玲符林春
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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