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Micromotor carrier and preparation method and application thereof

A micro-motor and carrier technology, applied in the field of micro-motors, can solve problems such as weak ability to cross cell and tissue barriers, and achieve the effect of improving delivery efficiency

Active Publication Date: 2021-10-15
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional micro-nano drug preparations mainly move through passive diffusion, and can only perform Brownian motion in body fluids, and their ability to cross cell and tissue barriers is relatively weak.

Method used

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  • Micromotor carrier and preparation method and application thereof
  • Micromotor carrier and preparation method and application thereof
  • Micromotor carrier and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The present embodiment provides a kind of unloaded micromotor carrier (microtablet form), and its preparation method comprises the following steps:

[0043] (1) Screen magnesium particles to obtain magnesium powder particles with a particle size of 9-15 μm; use magnesium particles as the core, and use ion sputtering (current 25-35mA, processing time 2-4min) to prepare coated Au the micro motor;

[0044](2) Using spin coating technology, the chitosan solution is coated on the surface of the micromotor, and the thickness of the chitosan coating is 1-3 μm; then use a 5-fold diluted phospholipid solution (cholesterol and lecithin 1:1 mixed) to The micromotor is coated with the spin coating method, and the thickness of the phospholipid film is about 1-3 μm. After tableting, the micromotor is coated with esterified starch (DS value 1.5-2.5) to obtain a non-drug-loaded micromotor carrier (such as figure 1 Shown), its particle size is 15-20μm.

[0045] like figure 2 As sho...

Embodiment 2

[0047] This embodiment provides a micromotor carrier (microtablet form) loaded with insulin, according to image 3 The process flow shown and the schematic diagram of insulin oral delivery, its preparation method comprises the following steps:

[0048] (1) Screen magnesium particles to obtain magnesium powder particles with a particle size of 9-15 μm; use magnesium particles as the core, and use ion sputtering (current 25-35mA, processing time 2-4min) to prepare coated Au the micro motor;

[0049] (2) adopt spin-coating technology, the chitosan solution (the concentration of insulin in chitosan solution is 1wt%) that will be loaded with insulin is coated on micromotor surface, and the chitosan coating thickness is at 1-3 μ m; Use a 5-fold diluted phospholipid solution (cholesterol and lecithin 1:1 mixture) to coat the micromotor by spin coating. The thickness of the phospholipid film is about 1-3 μm. -2.5) Coating the micromotors to obtain insulin-loaded micromotor carriers ...

Embodiment 3

[0052] This embodiment provides a micromotor carrier (microtablet form) loaded with insulin, according to image 3 The process flow shown and the schematic diagram of insulin oral delivery, its preparation method comprises the following steps:

[0053] (1) Screen magnesium particles to obtain magnesium powder particles with a particle size of 20-28 μm; use magnesium particles as the core, and use ion sputtering (current 25-35mA, processing time 2-4min) to prepare coated Au the micro motor;

[0054] (2) adopt spin-coating technology, the chitosan solution (the concentration of insulin in chitosan solution is 1wt%) that will be loaded with insulin is coated on micromotor surface, and the chitosan coating thickness is at 1-3 μ m; Use a 5-fold diluted phospholipid solution (cholesterol and lecithin 1:1 mixture) to coat the micromotor by spin coating. The thickness of the phospholipid film is about 1-3 μm. -2.5) Coating the micromotor to prepare a micromotor carrier loaded with i...

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Abstract

The invention belongs to the technical field of micromotors, and discloses a micromotor carrier and a preparation method and application thereof. The micromotor carrier comprises a magnesium-based micromotor, an Au coating layer, a chitosan coating, a phospholipid layer and an esterified starch layer from inside to outside. The micromotor carrier is a self-driven micromotor, has a good colon targeting characteristic, is suitable for being used as an oral administration carrier of drugs, especially polypeptide and protein drugs, and can improve the contact probability of colon and the infiltration capacity of the colon to intestinal mucosa, so that the acceptable daily intake and bioavailability of the colon part to the drugs are improved.

Description

technical field [0001] The invention belongs to the technical field of micro-motors, and in particular relates to a micro-motor carrier and a preparation method and application thereof. Background technique [0002] Oral administration has the advantages of good compliance, simplicity and convenience, and is an ideal way of administration. However, when polypeptide biomacromolecular drugs (such as insulin) pass through the human digestive tract, the harsh digestive environment in the gastrointestinal tract can easily lead to damage to the drug structure and activity, resulting in a decrease in its bioavailability. However, traditional insulin preparations mainly achieve the therapeutic effect through subcutaneous injection, which has the disadvantages of inconvenient administration, and long-term injection will cause harm to the skin and subcutaneous tissue, and it is easy to cause adverse risks such as allergies. Therefore, how to improve the delivery ability of insulin in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K38/28A61K47/02A61K47/36A61K47/28A61K47/24
CPCA61K9/5078A61K9/5089A61K9/5036A61K9/5015A61K9/501A61K38/28A61K47/02
Inventor 涂盈锋刘坤刘秋月王双虎杨佳蓉
Owner SOUTHERN MEDICAL UNIVERSITY
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