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Preparation method of ultra-high molecular weight poly-L-lactic acid

A technology of L-polylactic acid and ultra-high molecular weight, which is applied in the field of preparation of ultra-high molecular weight L-lactic acid, can solve the problems of long preparation time, poor controllability of molecular weight distribution, and high dosage of initiator and catalyst, so as to reduce the dosage and shorten the process Time, optimize the effect of heating

Pending Publication Date: 2021-10-19
上海曜爱生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned inventions can prepare high-molecular-weight L-polylactic acid products by lactide ring-opening polymerization, but their disadvantages are long preparation time, high dosage of initiators and catalysts, and poor controllability of molecular weight distribution.

Method used

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  • Preparation method of ultra-high molecular weight poly-L-lactic acid
  • Preparation method of ultra-high molecular weight poly-L-lactic acid
  • Preparation method of ultra-high molecular weight poly-L-lactic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Weigh 3kg of L-lactide and place it in a pre-treated glass reactor (5L), then put it into a microwave ultrasonic reactor and heat it to 110°C until the monomer melts, add 0.2713g of n-octanol, control The molar ratio of L-lactide to initiator was 10000:1, and then 0.0105 g of stannous octoate was added to make the molar ratio of L-lactide to catalyst 800000:1. Vacuumize the reactor to below 100Pa, then break the vacuum with argon to replace the residual air in the system, repeat this operation 3 times, and finally vacuumize to below 100Pa and perform sealing treatment; set the microwave radiation power to 90W, ultrasonic The frequency is 25KHz, so that the L-lactide monomer can be fully mixed with the catalyst, and finally the polymerization reaction is carried out at 65°C for 8 hours; after the reaction is completed, the block L-lactic acid material is sliced ​​and frozen in liquid nitrogen Put it into a pulverizer to obtain granular L-lactic acid; remove imp...

Embodiment 2

[0027] Example 2 Weigh 3kg of L-lactide and place it in a pre-treated glass reactor (5L), then put it into a microwave ultrasonic reactor and heat it to 110°C until the monomer melts, add 0.2713g of n-octanol, and control The molar ratio of L-lactide to the initiator was 10000:1, and 1.0549 g of stannous octoate was added to make the molar ratio of L-lactide to the catalyst 8000:1. Vacuumize the reactor to below 100Pa, then break the vacuum with argon to replace the residual air in the system, repeat this operation 3 times, and finally vacuumize to below 100Pa and perform sealing treatment; set the microwave radiation power to 90W, ultrasonic The frequency is 25KHz, so that the L-lactide monomer can be fully mixed with the catalyst, and finally the polymerization reaction is carried out at 65°C for 8 hours; after the reaction is completed, the block L-lactic acid material is sliced ​​and frozen in liquid nitrogen Put it into a pulverizer to obtain granular L-lactic acid; remov...

Embodiment 3

[0028] Example 3 Weigh 3kg of L-lactide and place it in a pretreated glass reactor (5L), then put it into a microwave ultrasonic reactor and heat it to 110°C until the monomer melts, add 0.6783g of n-octanol, and control The molar ratio of L-lactide to the initiator was 4000:1, and 1.0549 g of stannous octoate was added to make the molar ratio of L-lactide to the catalyst 8000:1. Vacuumize the reactor to below 100Pa, then break the vacuum with argon to replace the residual air in the system, repeat this operation 3 times, and finally vacuumize to below 100Pa and perform sealing treatment; set the microwave radiation power to 90W, ultrasonic The frequency is 25KHz, so that the L-lactide monomer can be fully mixed with the catalyst, and finally the polymerization reaction is carried out at 65°C for 8 hours; after the reaction is completed, the block L-lactic acid material is sliced ​​and frozen in liquid nitrogen Put it into a pulverizer to obtain granular L-lactic acid; remove ...

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Abstract

The invention discloses a preparation method of ultra-high molecular weight poly (L-lactic acid), which comprises the following steps: carrying out ring opening polymerization on L-lactide by adopting a microwave ultrasonic method to prepare poly (L-lactic acid), and carrying out supercritical treatment on the poly (L-lactic acid) to realize high yield and high molecular weight centralized controllability of the poly (L-lactic acid). And the beneficial effects of improving the production benefit, reducing the cost and protecting the environment are achieved.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a preparation method of ultra-high molecular weight L-polylactic acid. Background technique [0002] Polylactic acid (PLA) is a new type of green material with good biocompatibility and biodegradability. PLA is a polymer material formed by the polymerization of small molecule lactic acid from biomass raw materials (starch) fermented by microorganisms. 2 and H 2 O participates in the metabolism of the human body. Therefore, PCL has broad prospects in biomedical fields, such as tissue repair engineering, drug controlled release, medical sutures, and so on. At present, the synthesis and preparation of ultra-high molecular weight polylactic acid is also a major research hotspot. Its excellent thermodynamic properties can replace metal materials as biodegradable orthopedic implant materials. For example, degradable bone nails require a molecular weight of more than one million. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/08C08G63/85
CPCC08G63/08C08G63/85Y02P20/54
Inventor 孙乐青周慧丽张婷婷赵瑾柳仁民
Owner 上海曜爱生物科技有限公司
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