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Preparation method of plasma separation membrane

A technology of plasma separation membrane and diamino, applied in the field of plasma separation membrane, can solve the problems of hemolysis separation accuracy and efficiency, and achieve the effect of low cost, simple process and good separation effect

Active Publication Date: 2021-10-22
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems of easy hemolysis and poor separation accuracy and efficiency in the traditional autologous blood separation and purification technology in clinical operation, the present invention proposes a new method for preparing plasma separation membrane

Method used

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  • Preparation method of plasma separation membrane
  • Preparation method of plasma separation membrane
  • Preparation method of plasma separation membrane

Examples

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Embodiment 1

[0027] This example provides the specific preparation process of the plasma separation membrane.

[0028] O-carboxymethyl chitosan was dissolved in 10 ml DMSO (0.05 M concentration), and HOBT (0.005 M), N-tert-butoxycarbonylethylenediamine (0.05 M) and EDCI ( 0.1 M), stirring at 100rpm, reacting at 0°C for 36h, filtering and washing with saturated sodium carbonate solution to obtain bisaminochitosan derivatives protected by tert-butoxycarbonyl groups, adding 5ml trifluoroacetic acid for 2h and then adding 30ml saturated carbonic acid The sodium aqueous solution was stirred for 1 h, filtered and washed with 20 ml of saturated sodium bicarbonate solution to obtain bisamino chitosan derivatives. The prepared diaminochitosan derivative (0.1g) was blended with graphene oxide (0.1g). After ultrasonication for 45min, DMAP (0.23g) and DCC (2.3g) were added, and stirred at reflux for 36 h. The solution was washed with deionized water, methanol, and acetone each with 30ml, and then dri...

Embodiment 2

[0031] (1) Dissolve O-carboxymethyl chitosan in 10 ml of dichloromethane (concentration: 0.15 M), add HOBT (0.15 M), N-tert-butoxycarbonylethylenediamine (0.3 M) and EDCI (0.3 M), stirred at 800rpm, reacted at 30°C for 12h, filtered and washed with saturated sodium bicarbonate to obtain a bisaminochitosan derivative protected by tert-butoxycarbonyl, added 5ml trifluoroacetic acid to react for 2h Then add potassium carbonate aqueous solution and continue to stir for 1 h, obtain bisamino chitosan derivatives after filtering and washing. Add 8ml of trifluoroacetic acid to react for 2h, add 40ml of saturated sodium carbonate aqueous solution and continue to stir for 2h, filter and wash with 20ml of saturated sodium bicarbonate solution to obtain diaminochitosan derivatives. The prepared diaminochitosan derivative (0.15g) was blended with graphene oxide (0.1g). After ultrasonication for 60min, DMAP (0.23g) and DCC (2.3g) were added and stirred at reflux for 24 h. The solution was ...

Embodiment 3

[0034](1) Dissolve O-carboxymethyl chitosan in 10 ml of chloroform (concentration: 0.1 M), add HOBT (0.02 M), N-tert-butoxycarbonylethylenediamine (0.1 M) to the mixed solution and EDCI (0.15 M), stirring at 1000 rpm, reacting at 10 degrees for 24 hours, filtering and washing with saturated potassium carbonate solution, to obtain bisaminochitosan derivatives protected by tert-butoxycarbonyl groups, adding 15ml of trifluoroacetic acid to react for 12 hours and then adding 100ml of saturated aqueous sodium carbonate solution continued to stir for 4h, filtered and washed with 20ml of saturated sodium bicarbonate solution to obtain a diaminochitosan derivative. The prepared diaminochitosan derivative (0.1g) was blended with graphene oxide (0.15g). After ultrasonication for 30min, DMAP (0.23g) and DCC (2.3g) were added and stirred at reflux for 48 h. The solution was washed with deionized water, methanol, and acetone with 30ml each, and then dried at 30°C for 48h to obtain a diamin...

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Abstract

The invention belongs to the technical field of plasma separation membranes, and relates to a preparation method of a plasma separation membrane. The invention discloses a membrane with a plasma separation function, which is prepared on the basis of a membrane separation technology. The preparation method comprises the following steps: synthesizing a diamino chitosan-graphene oxide hybrid material, enabling the hybrid material to deposit a membrane on an aluminum oxide hollow fiber support body through a vacuum suction filtration method, and adjusting the membrane structure by controlling conditions such as concentration and deposition time of the hybrid material, so as to achieve the purpose of separating plasma. The preparation method is simple in process, relatively low in cost and good in separation effect, and has a prospect of large-scale process production.

Description

technical field [0001] The invention belongs to the technical field of plasma separation membranes, and relates to a preparation method of plasma separation membranes. Background technique [0002] With the rapid development of my country's medical and health services, medical technology and hygiene levels have been significantly improved, the public's demand for medical services is increasing, the number of operations is increasing sharply, and the amount of blood used in clinical medicine continues to increase. However, due to the shortage of blood sources, the blood supply is becoming increasingly tense, and the problem of "blood shortage" is serious. Some operations have been canceled because the relevant blood sources cannot be prepared, which seriously affects the treatment of patients. At the same time, in clinical practice, allogeneic blood transfusion may lead to potential complications and adverse reactions such as viral infection, immunosuppression, transfusion-re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D67/00B01D69/08B01D69/10B01D71/74
CPCB01D71/74B01D67/0079B01D69/08B01D69/10
Inventor 谢颖储震宇金万勤
Owner NANJING UNIV OF TECH
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