Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Preparation method of chlorquinaldol

A technology of chloroquinaldol and methylquinoline, which is applied in the field of drug synthesis, can solve the problems of large amount of sodium hypochlorite solution, increased cost of waste liquid treatment, and reduced yield, so as to avoid the generation and increase of impurities, and the requirements are not high. The effect of reducing production time

Pending Publication Date: 2021-10-22
北京斯利安药业有限公司
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] This process eliminates the pollution of chlorine gas, but still uses highly volatile hydrochloric acid, and the amount of sodium hypochlorite solution is large, which will dissolve part of the generated product during the reaction process, resulting in a decrease in yield, and more waste liquid generated, increasing cost of waste disposal

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of chlorquinaldol
  • Preparation method of chlorquinaldol
  • Preparation method of chlorquinaldol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Put 10g of 8-hydroxy-2-methylquinoline, 50mL of dichloromethane and 0.35g of aluminum chloride into a 250mL reaction bottle, stir and cool down to 20-30°C, add 7.8g of dichlorohydantoin, and keep warm at 32-41°C Reaction 7h.

[0065] Cool the reaction solution to 20-30°C, filter, add 15mL of concentrated hydrochloric acid dropwise to the filtrate, precipitate out, filter, add 150mL of water, stir to dissolve, slowly add ammonia water until the pH is 2.8, precipitate solid, filter, rinse, Dried rough.

[0066] The crude product was refined with 160 mL of absolute ethanol and 20 mL of water to obtain 8.7 g of pure chloroquinaldol, with a yield of 60.32% and a HPLC purity of 99.23%.

Embodiment 2

[0068] Put 20g of 8-hydroxy-2-methylquinoline, 200mL of chloroform and 1.0g of aluminum chloride into a 500mL reaction bottle, stir and cool down to 20-30°C, add 15.3g of dichlorohydantoin, and keep it warm at 32-41°C for 8h .

[0069] Cool the reaction solution to 20-30°C, filter, add 20mL of concentrated hydrochloric acid dropwise to the filtrate, precipitate out, filter, add 200mL of water, stir to dissolve, slowly add ammonia water until the pH is 3.5, precipitate solid, filter, rinse, Dried rough.

[0070] The crude product was refined with 280 mL of absolute ethanol and 30 mL of water to obtain 19.0 g of pure chloroquinaldol, with a yield of 65.85% and a HPLC purity of 99.43%.

Embodiment 3

[0072] Put 10g of 8-hydroxy-2-methylquinoline, 80mL of dichloromethane and 0.5g of aluminum chloride into a 250mL reaction bottle, stir and cool down to 20-30°C, add 7.7g of dichlorohydantoin, and keep warm at 32-41°C Reaction 9h.

[0073] Cool the reaction solution to 20-30°C, filter, add 12mL of concentrated hydrochloric acid dropwise into the filtrate, precipitate out, filter, add 100mL of water, stir to dissolve, slowly add ammonia water until the pH is 4.0, precipitate solid, filter, rinse, Dried rough.

[0074] The crude product was refined with 100 mL of acetonitrile and 10 mL of water to obtain 9.5 g of pure chloroquinaldol, with a yield of 66.05% and an HPLC purity of 99.71%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation method of chlorquinaldol. The preparation method comprises the following step: in the presence of a catalyst Lewis acid, subjecting a material I containing 8-hydroxy-2-methylquinoline and dichlorohydantoin to reacting so as to obtain the chlorquinaldol. According to the invention, dichlorohydantoin is used as a reaction raw material to replace chlorine, so good selectivity is achieved, byproducts are few, reaction operability is strong, light shielding and gas protection are not needed, quality and yield are improved, the purity of chlorquinaldol is 99.00% or more, and the quality of chlorquinaldol is ensured. In the reaction process, generation of waste liquid is reduced, pollution to the environment is avoided to the maximum extent, cost is saved, quality is improved, and the method is an environment-friendly process suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of drug synthesis, in particular to a preparation method of chloroquinaldol. Background technique [0002] Chlorquinaldol is a broad-spectrum bacteriostatic agent with the following structure: [0003] [0004] The chemical name is: 5,7-dichloro-8-hydroxy-2-methylquinoline, the molecular weight is 228.07, it is a yellow needle-like crystal with a slightly pungent smell, and it has antifungal, trichomonas, bacteria (G+ and G-), antimicrobial pathogen activity such as chlamydia and mycoplasma. Because it is slightly soluble in water, pathogenic microorganisms generally enter the pathogenic cells through endocytosis, which changes the pH value of the pathogenic cells, inhibits the metabolism of the pathogens, and eventually leads to the death of the pathogens, while human epithelial cells have no phagocytosis function for chloroquinaldol, so the When the medicine is used externally, it has less adverse rea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D215/28
CPCC07D215/28
Inventor 阮长浩廖俊凯张书彬郑莎易斌
Owner 北京斯利安药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com