Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of clarithromycin capsule

A technology for clarithromycin and capsules, which is applied in the field of preparation of clarithromycin capsules, can solve the problems that affect the comprehensive performance of clarithromycin capsules, the percentage of granules are sticky and punched, the difference in capsule filling volume needs to be improved, etc., and achieves low price and easy acquisition. Effect

Pending Publication Date: 2021-10-29
HAINAN HAISHEN TONGZHOU PHARM CO LTD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The granule percentage of clarithromycin capsules currently on the market, the stickiness during filling, and the difference in capsule filling volume all need to be improved, which affects the overall performance of clarithromycin capsules

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of clarithromycin capsule
  • Preparation method of clarithromycin capsule
  • Preparation method of clarithromycin capsule

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0018] The present invention provides a kind of preparation method of clarithromycin capsule, comprises the following steps:

[0019] a. Mix clarithromycin and diluent according to the prescription amount, add binder, and stir quickly to make wet granules;

[0020] b. drying the prepared wet granules into dry granules;

[0021] c. The dry granules are sieved and granulated, and mixed with a lubricant;

[0022] d. Determine the content of clarithromycin in the granules to determine the weight of the granules;

[0023] e, filling as capsules.

[0024] The diluent is starch, the binder is starch slurry, and the lubricant is magnesium stearate.

[0025] Further, step a is also included before step a 0 : Sieve starch and magnesium stearate through 100 sieves.

[0026] The drying temperature in the step b is 60°C; in the step c, the dry granules are passed through a 18-mesh sieve for granulation.

[0027] The embodiment of the present invention utilizes four factors and three ...

Embodiment 1

[0032] In this example, 1000 clarithromycin capsules were prepared, and 250.0 g clarithromycin was directly filled into capsules without adding auxiliary materials (starch, starch slurry concentration, magnesium stearate).

Embodiment 2

[0034] The present embodiment prepares 1000 clarithromycin capsules, the steps are as follows:

[0035] a 0 100 mesh sieves are passed through the magnesium stearate;

[0036] a. Add 250 g of clarithromycin and 50 ml of starch slurry with a concentration of 8% to the wet granulator, stir rapidly for 5 minutes, and prepare wet granules;

[0037] b. Drying the prepared wet granules at 60°C into dry granules;

[0038] c. The dry granules are passed through a 18-mesh sieve for granulation, and 2.7 g of magnesium stearate is added and mixed;

[0039] d. Determine the content of clarithromycin in the granules to determine the weight of the granules;

[0040] e. Capsule filling is carried out with a capsule filling machine, and the empty capsule shell is a No. 0 capsule.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation method of the clarithromycin capsule, which comprises the following steps: a, mixing the clarithromycin and the diluent according to a prescription dosage, adding the adhesive, and quickly stirring to prepare wet particles; b, drying the prepared wet particles into dry particles; c, sieving and finishing the dry particles, adding a lubricant and mixing; d, measuring the content of clarithromycin in the particles, and determining the weight of the particles; and e, filling into capsules. The diluent is starch, the adhesive is starch slurry, and the lubricant is magnesium stearate. By utilizing the preparation method of the clarithromycin capsule provided by the invention, the clarithromycin capsule with better comprehensive performance of particle percentage (percentage of particles not passing through 30 meshes accounting for the total amount), sticking during filling and capsule filling quantity difference can be prepared, and auxiliary materials required for preparation are low in price and easy to obtain.

Description

technical field [0001] The invention relates to a preparation method of a pharmaceutical preparation, in particular to a preparation method of clarithromycin capsules. Background technique [0002] Clarithromycin is a macrolide antibiotic, and its mechanism of action is to inhibit the binding of the 50s subunit of nuclear protein and inhibit protein synthesis to produce antibacterial effect. Compared with arithromycin, its antibacterial activity in vitro is similar, but its antibacterial activity against some bacteria (such as Staphylococcus aureus, Streptococcus, Haemophilus influenzae, etc.) in vivo is stronger than that of erythromycin. In addition to the original effect of erythromycin on Gram-positive bacteria, it is also effective on some Gram-negative bacteria (such as Haemophilus influenzae, Bordetella pertussis, Neisseria gonorrhoeae, Legionella pneumophila) and some anaerobic bacteria ( Such as Bacteroides fragilis, Peptostreptococcus, Propionibacterium acnes, etc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/12A61K31/7048A61P31/04
CPCA61K9/1652A61K9/1617A61K9/1682A61K31/7048A61P31/04
Inventor 韦家华刘玉李丙寅
Owner HAINAN HAISHEN TONGZHOU PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com