Medical hemostatic composite material and preparation method thereof

A composite material and composite polysaccharide technology, applied in the field of medical materials, can solve the problems of affecting wound healing time, secondary infection, poor antibacterial effect, etc., and achieve the effect of inhibiting the growth of bacteria, protecting wounds, and good water retention

Inactive Publication Date: 2021-11-02
广州市周平喜医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Uncontrolled hemorrhage is the most important cause of death in wars, traffic accidents and other accidental injuries. Effective hemostasis is inseparable from the application of hemostatic materials. Although traditional hemostatic materials can play a very important role in rescuing the wounded and saving lives in a short period of time, they are almost ineffective for large blood vessel bleeding or bleeding from large wounds. At the same time, the antibacterial effect of traditional hemostatic materials is poor, and external bacteria can enter the human body through the wound to cause secondary infection, which seriously affects the healing time of the wound

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) In parts by weight, weigh 10 parts of pullulan, 8 parts of chitosan, 2 parts of ε-polylysine with a molecular weight of 3600, 3 parts of sodium citrate, and 1 part of carboxymethyl cellulose Sodium, 20 parts deionized water.

[0039] Add chitosan and sodium citrate into deionized water, and stir at 500 r / min for 30 minutes in a water bath at 60°C to obtain a chitosan mixture;

[0040] (2) Add pullulan, ε-polylysine and sodium carboxymethylcellulose into the chitosan mixture, stir at 500r / min for 1 hour in a water bath at 60°C, and form the polysaccharide mixture;

[0041] (3) Put the polysaccharide mixture in an ultrasonic cell pulverizer, and ultrasonically treat it with a power of 500W for 1 hour at room temperature to obtain a self-made modified composite polysaccharide solution;

[0042] (4) In parts by weight, weigh 30 parts of self-made modified compound polysaccharide solution, 1 part of gum arabic, 1 part of gelatin, 1 part of sodium hyaluronate, 5 parts of c...

Embodiment 2

[0047] (1) In parts by weight, weigh 11 parts of pullulan, 9 parts of chitosan, 3 parts of ε-polylysine with a molecular weight of 3900, 4.5 parts of sodium citrate, and 1.5 parts of carboxymethylcellulose Sodium, 25 parts deionized water.

[0048] Add chitosan and sodium citrate into deionized water, and stir at 550r / min for 35min in a water bath at 65°C to obtain a chitosan mixture;

[0049] (2) Add pullulan, ε-polylysine and sodium carboxymethylcellulose into the chitosan mixture, stir at 550r / min for 1.5h in a water bath at 65°C, and the polysaccharide mixture ;

[0050] (3) Put the polysaccharide mixture in an ultrasonic cell pulverizer, and ultrasonically treat it with a power of 550W for 1.5 hours at room temperature to obtain a self-made modified composite polysaccharide solution;

[0051] (4) In parts by weight, weigh 45 parts of self-made modified compound polysaccharide solution, 2 parts of gum arabic, 2.5 parts of gelatin, 2.5 parts of sodium hyaluronate, 8.5 par...

Embodiment 3

[0056] (1) In parts by weight, weigh 12 parts of pullulan, 10 parts of chitosan, 4 parts of ε-polylysine with a molecular weight of 4300, 6 parts of sodium citrate, and 2 parts of carboxymethylcellulose Sodium, 30 parts deionized water.

[0057] Add chitosan and sodium citrate to deionized water, and stir at 600r / min for 40min in a water bath at 70°C to obtain a chitosan mixture;

[0058] (2) Add pullulan, ε-polylysine and sodium carboxymethyl cellulose to the chitosan mixture, stir at 600r / min for 2 hours in a water bath at 70°C, and obtain the polysaccharide mixture;

[0059] (3) Put the polysaccharide mixture in an ultrasonic cell pulverizer, and ultrasonically treat it with a power of 600W for 2 hours at room temperature to obtain a self-made modified composite polysaccharide solution;

[0060] (4) In parts by weight, weigh 60 parts of self-made modified compound polysaccharide solution, 3 parts of gum arabic, 4 parts of gelatin, 4 parts of sodium hyaluronate, 12 parts of...

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PUM

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Abstract

The invention discloses a medical hemostatic composite material. The medical hemostatic composite material comprises the following raw materials: 30-60 parts of a self-made modified compound polysaccharide solution, 1-3 parts of Arabic gum, 1-4 parts of gelatin, 1-4 parts of sodium hyaluronate, 5-12 parts of calcium chloride, 2-4 parts of stearic acid, 2-8 parts of polyethylene glycol, 0.5-4 parts of polyoxyethylene sorbitan monooleate, 2-4 parts of glycerol monolaurate, 10-20 parts of glycerol, 0.5-2 parts of hydrogen peroxide, 0.5-2 parts of tannic acid and 45-70 parts of deionized water. The invention also discloses a preparation method of the medical hemostatic composite material. The medical hemostatic composite material prepared by the invention has good hemostatic and antibacterial effects.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a medical hemostatic composite material and a preparation method thereof. Background technique [0002] Uncontrolled hemorrhage is the most important cause of death in wars, traffic accidents and other accidental injuries. Effective hemostasis is inseparable from the application of hemostatic materials. Although traditional hemostatic materials can play a very important role in rescuing the wounded and saving lives in a short period of time, they are almost ineffective for large blood vessel bleeding or bleeding from large wounds. At the same time, the antibacterial effect of traditional hemostatic materials is poor, and external bacteria can enter the human body through the wound to cause secondary infection, which seriously affects the healing time of the wound. Contents of the invention [0003] In view of the above-mentioned defects, the present invention provide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/04A61L24/00
Inventor 陈国林
Owner 广州市周平喜医疗科技有限公司
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