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Preparation process of ganoderma lucidum spore oil soft capsule

A technology of Ganoderma lucidum spore oil and Ganoderma lucidum spores is applied in the directions of capsule delivery, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. It can solve the problem that the disintegration time of soft capsules affects product stability and quality, extraction failure, The separation kettle is easy to block and other problems, so as to achieve the effect of improving the wall breaking rate, improving the extraction rate and high biological activity.

Pending Publication Date: 2021-11-05
康道生物(南通)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Ganoderma lucidum spore oil soft capsules in the prior art are filtered and extracted by ultra-fine pulverizer, because the spore powder has a high degree of refinement during extraction, and the pipeline is easily blocked when the gas enters the separation tank, resulting in extraction failure; the soft capsule filling The oil particles are dripped on the surface of the gelatin, and then the rubber is sealed when it is lowered by the acceleration of gravity, and it forms a spherical shape under the action of surface tension and gradually solidifies into a soft capsule. The peptide fragments hydrolyzed by gelatin collagen and amino acid molecules undergo cross-linking reactions. During storage, there are problems that the disintegration time of the soft capsule is prolonged, and the capsule shell and the content of Ganoderma lucidum bun oil contact the inner wall to form a film, which affects the stability and quality of the product.

Method used

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  • Preparation process of ganoderma lucidum spore oil soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A kind of preparation technology of Ganoderma lucidum spore oil soft capsule, its processing step is as follows:

[0023] S1: take the ganoderma lucidum spore raw material, sieve and granulate the ganoderma lucidum spore granules after ultrafine pulverization and wall breaking;

[0024] Supercritical CO is used in ultrafine pulverization and wall breaking treatment 2 Through the nozzle, the ganoderma spore raw material is brought to hit the hard target at a pressure of 35MPa and a temperature of -12°C for jet crushing, and the pressure is reduced to 8Mpa to separate and obtain the ganoderma spore powder. The sieving fineness is 300 mesh. The granulation mechanism of the ganoderma spore powder is as follows: 80 mesh ganoderma spores and vacuum-dried;

[0025] S2: Take Ganoderma lucidum spores and undergo supercritical extraction and separation to obtain Ganoderma lucidum spore oil, Ganoderma lucidum spore oil and Ganoderma lucidum spore powder, soybean lecithin, active ...

Embodiment 2

[0033] A kind of preparation technology of Ganoderma lucidum spore oil soft capsule, its processing step is as follows:

[0034] S1: take the ganoderma lucidum spore raw material, sieve and granulate the ganoderma lucidum spore granules after ultrafine pulverization and wall breaking;

[0035] Supercritical CO is used in ultrafine pulverization and wall breaking treatment 2 Through the nozzle, the ganoderma spore raw material is brought to hit the hard target at a pressure of 40MPa and a temperature of 5°C for jet crushing, and the pressure is reduced to 9Mpa to separate and obtain the ganoderma spore powder. The sieving fineness is 300 mesh, and the ganoderma spore powder is granulated to 60 Objective ganoderma lucidum spores and vacuum drying;

[0036] S2: Take Ganoderma lucidum spores and undergo supercritical extraction and separation to obtain Ganoderma lucidum spore oil. The mass ratio of Ganoderma lucidum spore oil to Ganoderma lucidum spore powder, soybean lecithin, a...

Embodiment 3

[0045] A kind of preparation technology of Ganoderma lucidum spore oil soft capsule, its processing step is as follows:

[0046] S1: take the ganoderma lucidum spore raw material, sieve and granulate the ganoderma lucidum spore granules after ultrafine pulverization and wall breaking;

[0047] Supercritical CO is used in ultrafine pulverization and wall breaking treatment 2 Through the nozzle, the ganoderma spore raw material is brought to hit the hard target at a pressure of 26MPa and a temperature of 10°C for jet crushing, and the pressure is reduced to 8Mpa to separate and obtain the ganoderma spore powder. The sieving fineness is 300 mesh, and the ganoderma spore powder is granulated to 100 Objective ganoderma lucidum spores and vacuum drying;

[0048] S2: Take Ganoderma lucidum spores and undergo supercritical extraction and separation to obtain Ganoderma lucidum spore oil. The mass ratio of Ganoderma lucidum spore oil and Ganoderma lucidum spore powder, soybean lecithin...

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Abstract

The invention relates to a preparation process of a ganoderma lucidum spore oil soft capsule. The preparation process comprises the following steps: taking a ganoderma lucidum spore raw material, carrying out superfine grinding wall breaking treatment, sieving, granulating to obtain ganoderma lucidum spore granules, carrying out supercritical extraction, separating to obtain ganoderma lucidum spore oil, preparing soft capsule contents from the ganoderma lucidum spore oil with ganoderma lucidum spore powder, soybean lecithin, active peptides, docosahexaenoic acid and vitamins, taking the soft capsule contents and sealing layer mucilage, carrying out glue dripping molding, carrying out fluidized bed spraying, coating with binding layer mucilage and sustained-release layer mucilage in sequence, and carrying out drying and shaping to obtain a finished product. The sealing layer mucilage, the binding layer mucilage and the sustained-release layer mucilage wrap the ganoderma lucidum spore oil compound soft capsule contents to prepare the ganoderma lucidum spore oil soft capsule with multiple layers of capsule shells, the sealing layer mucilage blocks the self-oxidation or cross-linking effect of amino acid residues in the soft capsule content and gelatin, the binding layer mucilage increases the binding property and avoids layering, the sustained-release layer mucilage is antioxidant and controllable in release, so that the disintegration time is prevented from being prolonged, and the quality stability and biological activity of the product are improved.

Description

technical field [0001] The invention relates to a preparation process of ganoderma lucidum spore oil soft capsules, belonging to the technical field of spore oil soft capsules. Background technique [0002] Ganoderma lucidum spore oil soft capsule is made of broken Ganoderma lucidum spore powder as raw material, and refined from fat-soluble substances extracted by supercritical CO2 fluid. It is a health product mainly used for adjuvant therapy and daily health care of tumor patients. The Ganoderma lucidum spore oil soft capsules in the prior art are filtered and extracted by ultra-fine pulverizer, because the spore powder has a high degree of refinement during extraction, and the pipeline is easily blocked when the gas enters the separation tank, resulting in extraction failure; the soft capsule filling The oil particles are dripped on the surface of the gelatin, and then the rubber is sealed when it is lowered by the acceleration of gravity, and it forms a spherical shape ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L31/00A23L33/10A23L33/115A23L33/18A23L33/12A23L33/155A23P10/30A23P20/20A61K36/074A61K9/48A61K47/36A61P35/00
CPCA23L31/00A23L33/10A23L33/115A23L33/18A23L33/12A23L33/155A23P10/30A23P20/20A61K36/074A61K9/4816A61K47/36A61P35/00A61K2236/37A23V2002/00A23V2250/208A23V2300/44A23V2300/48A23V2300/14A23V2250/18A23V2250/55A23V2250/1882A23V2250/702A23V2250/71A23V2250/712A23V2250/714A23V2250/5108A23V2250/5076A23V2250/5432A23V2250/6406A23V2250/5024A23V2250/506A23V2250/511A23V2250/5072A23V2250/5022A23V2200/242A23V2250/5118A23V2250/5026
Inventor 施小燕
Owner 康道生物(南通)有限公司
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