Method for preparing 2,4-dichloroacetophenone
A technology of dichloroacetophenone and m-dichlorobenzene, which is applied to the preparation of carbon-based compounds, chemical instruments and methods, and the preparation of organic compounds, which can solve the problems of low preparation yield and poor purity, and achieve simple synthesis process , Promote dissolution and reduce reaction time
Pending Publication Date: 2021-11-09
NINGXIA RUITAI TECH +1
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Abstract
The invention discloses a method for preparing 2,4-dichloroacetophenone. The method comprises the following steps: S1, weighing dichlorobenzene, aluminum trichloride and an amide auxiliary agent, and carrying out mixing and stirring; S2, when a stirring temperature rises to 40 DEG C, dropwise adding acetyl bromide for a reaction so as to obtain 2, 4-dichloroacetophenone synthetic liquid; S3, adding the 2,4-dichloroacetophenone synthetic liquid obtained in the step 2 into hydrochloric acid for acidolysis layering, and separating and washing an oil layer after layering; S4, dehydrating the washed oil layer in a vacuum environment system, and removing light components when the temperature rises to 98 DEG C; and S5, rectifying the residues after dehydration and light component removal to obtain the 2,4-dichloroacetophenone. According to the invention, acetyl bromide is adopted as a raw material, so the activity of an electrophilic reagent can be effectively reduced, and the yield of the product can be further improved. Meanwhile, the amide auxiliary agent is supplemented in the preparation process of the 2,4-dichloroacetophenone synthetic liquid, so the dissolution of aluminum trichloride is promoted, a contact area of reactants is increased, and reaction efficiency is greatly improved.
Application Domain
Organic compound preparationCarbonyl compound preparation by condensation +1
Technology Topic
Aluminum trichlorideAcetophenone +9
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