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Bionic skin scaffold and preparation method thereof

A skin and dermis technology, applied in the field of bionic skin scaffolds and its preparation, can solve the problems of tissue generation rate mismatch

Active Publication Date: 2021-11-19
NOVAPRINT THERAPEUTICS SUZHOU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the through-hole porosity of the dermis is uniform, which does not match the tissue generation rate when repairing the skin

Method used

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  • Bionic skin scaffold and preparation method thereof
  • Bionic skin scaffold and preparation method thereof
  • Bionic skin scaffold and preparation method thereof

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Experimental program
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Effect test

preparation example Construction

[0039] The preparation method of the above-mentioned bionic skin scaffold includes: sequentially injecting the gel solution of the dermis layer, the gel solution of the epidermis layer and the gel solution of the dense layer into the mold, and then cross-linking it by a composite cross-linking agent for 1-48 hours after it is shaped, Then demould.

[0040] The gel solution is used to prepare the above-mentioned biomimetic skin scaffold. On the one hand, the structure of the above-mentioned biomimetic skin scaffold can make the skin wound be repaired better; The three-layer structure of the bionic skin scaffold has no obvious boundaries, has better mechanical properties, and is closer to the structure of human skin.

[0041] In order to prepare the bionic skin scaffold with the above structure more conveniently, the structure of the mold can be improved. figure 2 For the schematic structural diagram of the skin mold provided by the embodiment of this application, please refer...

Embodiment 1

[0056] The preparation method of bionic skin support comprises the steps:

[0057] (1), configure dense layer gel solution: 25mg / ml sodium alginate, 5mg / ml chitosan, 5mg / ml sodium carboxymethylcellulose, 5mg / ml gelatin, 5mg / ml sodium hyaluronate and 5% glycerin.

[0058] Prepare epidermal gel solution: 20mg / ml sodium alginate, 10mg / ml collagen, 5mg / ml chitosan, 5mg / ml sodium carboxymethylcellulose, 10mg / ml gelatin and 3mg / ml sodium hyaluronate.

[0059]Prepare dermis gel solution: 15mg / ml sodium alginate, 20mg / ml collagen, 2mg / ml chitosan, 2mg / ml sodium carboxymethylcellulose, 20mg / ml gelatin and 2mg / ml sodium hyaluronate.

[0060] Configure composite cross-linking agent: cross-linking agent A component is 1% glutaraldehyde; cross-linking agent B component is 8% calcium chloride.

[0061] (2), first inject a certain amount of dermal layer gel solution into the skin mold, leveling; then inject a certain amount of epidermal gel solution into the skin mold, leveling; finally in...

Embodiment 2

[0064] Embodiment 2 is an improvement made on the basis of Embodiment 1. The difference of Embodiment 2 is that the skin mold in Embodiment 1 is placed in an environment of -80°C together with the gel solution inside for precooling. Then it was freeze-dried for 24 hours to set the shape; it was modified to: place the skin mold together with the gel solution inside in an environment of 4° C. for 3 hours to set the shape.

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Abstract

The invention provides a bionic skin scaffold and a preparation method thereof, and relates to the technical field of bionic skin scaffolds. The bionic skin scaffold comprises a compact layer, an epidermal layer and a corium layer which are sequentially arranged from top to bottom. The corium layer is provided with a plurality of first through holes and a plurality of second through holes which penetrate through the upper surface and the lower surface of the corium layer, the epidermal layer is provided with a plurality of third through holes which penetrate through the upper surface and the lower surface of the epidermal layer, one first through hole and one third through hole are correspondingly arranged and communicate, and the second through holes and the third through holes are arranged in a staggered mode and do not communicate. The sum of the hole area sum of the section holes of the plurality of first through holes and the hole area sum of the section holes of the plurality of second through holes is larger than the hole area sum of the section holes of the plurality of third through holes. The bionic skin scaffold simulates a full-thickness skin structure, has pores with different gradients, is beneficial to generation of blood vessels and accelerates wound repair.

Description

technical field [0001] The present application relates to the technical field of bionic skin stents, in particular, to a bionic skin stent and a preparation method thereof. Background technique [0002] The skin is the largest organ in the human body and has important physiological functions. The treatment of large-area skin defects caused by trauma, burns and scalds is a major clinical problem. Traditional autologous skin transplantation is still an important clinical treatment method for the treatment of large areas of severe full-thickness skin injuries, but there are problems such as shortage of sources and secondary injuries. [0003] In order to alleviate the above problems, artificial skin scaffolds are used for clinical treatment. The existing artificial skin scaffolds simulate the dermal structure of the skin to a certain extent and achieve clinical therapeutic effects, but there are still problems such as insufficient bionic degree of tissue structure. There are ...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/58A61L27/56A61L27/60A61L27/20A61L27/24A61L27/22
CPCA61L27/58A61L27/56A61L27/60A61L27/20A61L27/24A61L27/222
Inventor 杨熙牛长梅赵伟新周晨
Owner NOVAPRINT THERAPEUTICS SUZHOU CO LTD
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