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Bone cement hydrogel composite material for vertebroplasty and preparation method of bone cement hydrogel composite material

A technology of vertebroplasty and composite materials, applied in the field of bone cement hydrogel composite materials and its preparation, can solve the problems of surrounding tissue necrosis, accelerated intervertebral discs, compression of nerves, etc., to improve biocompatibility, absorb water and store water The effect of strong ability and good mechanical properties

Active Publication Date: 2021-11-26
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its main disadvantages in actual clinical application are as follows: 1) A large amount of heat is released during the polymerization process, and its maximum temperature exceeds the tolerance range of human tissues, reaching 80°C or even higher, resulting in necrosis of surrounding tissues, so PMMA bone cement is exothermic when solidified problems that need to be resolved
2) The PMMA material is non-degradable, and it is easy to loosen in the body for a long time, and it will affect the second operation. In addition, once the bone cement strengthens the vertebral body and then fractures, the bone cement can protrude to the spinal canal and compress the nerve; 3) PMMA The elastic modulus of PMMA is higher, which can lead to adjacent vertebrae fracture and accelerate intervertebral disc degeneration; 4) PMMA has no biological activity
[0005] But so far, there is still no report on the realization of a hybrid bone cement that can be used for vertebroplasty and can be loaded with bioactive factors.

Method used

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  • Bone cement hydrogel composite material for vertebroplasty and preparation method of bone cement hydrogel composite material
  • Bone cement hydrogel composite material for vertebroplasty and preparation method of bone cement hydrogel composite material
  • Bone cement hydrogel composite material for vertebroplasty and preparation method of bone cement hydrogel composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0043] A bone cement hydrogel composite material for vertebroplasty, prepared by the following method:

[0044] (1) Preparation of oxidized sodium hyaluronate:

[0045] Weigh 5g of sodium hyaluronate and add it to 500mL of ultrapure water, and keep stirring at room temperature until the oxidized sodium hyaluronate is completely dissolved. Then, 1 g of sodium periodate was weighed and dissolved in 5 mL of ultrapure water in the dark, and the dissolved sodium periodate solution was added dropwise to the oxidized sodium hyaluronate solution under dark conditions. After the mixed solution was stirred for 24 hours in the dark, 2 mL of ethylene glycol was added to terminate the reaction. Subsequently, the resulting reaction solution was put into a dialysis bag (MWCO 7000), and placed in ultrapure water for dialysis for 3 days, during which the water was changed three times a day. Finally, the solution was placed in a -20°C to -80°C ultra-low temperature refrigerator to freeze Afterw...

Embodiment 5-6

[0075] Osteogenesis tests were carried out with the bone cement hydrogel composite materials doped with osteogenic factors and bone cement hydrogel composite materials not doped with osteogenic factors respectively as samples:

[0076] (1) The composite material prepared by the present invention is: PMMA bone cement+15% hydrogel+BMP-2 sample aseptic production: the mold is sterilized, and aseptic tools are prepared, and it is completed in the ultra-clean bench. According to the amount of MMA liquid, add BMP-2 to the oxidized sodium hyaluronate solution at 20ug / ml, and prepare samples according to the method of the aforementioned Examples 1-5

[0077] (2) Preparation of extract: sample: medium = 1:5 (w / v), that is, 0.1 g / ml medium is placed in a 24-well plate, and extracted at 37° C. for 24 hours.

[0078] (3) ALP staining: Rat mesenchymal stem cells (inoculation size 10 5 / ml) after digestion and resuspension, planted in a 24-well plate, and after 24 hours, the culture medium ...

Embodiment 7

[0081] A bone cement hydrogel composite material for vertebroplasty, prepared by the following method:

[0082] (1) Preparation of oxidized sodium hyaluronate (same as Example 1):

[0083] (2) Dissolving 100 mg of oxidized sodium hyaluronate in 10 ml of deionized water to prepare an oxidized sodium hyaluronate solution;

[0084] 100mg carboxymethyl chitosan was dissolved in 10ml deionized water to prepare carboxymethyl chitosan solution;

[0085] Add osteogenic factor ALP to oxidized sodium hyaluronate solution or carboxymethyl chitosan solution;

[0086] (3) First add the powder component of the commercially available PMMA bone cement (SpinePlex bone cement) into a sterile vessel, and then add the liquid component and hydrogel (that is, oxidized hyaluronic acid containing osteogenic factor ALP) in proportion Sodium acid sodium solution and carboxymethyl chitosan solution), wherein the amount of ALP added is based on the amount of MMA in PMMA bone cement, and 5 μg of osteoge...

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Abstract

The invention relates to a bone cement hydrogel composite material for vertebroplasty and a preparation method of the bone cement hydrogel composite material. The bone cement hydrogel composite material comprises the following components in percentage by volume: 70-95% of PMMA bone cement and 5-30% of hydrogel. Compared with the prior art, according to the synthesized bone cement hydrogel composite material, the content of PMMA is reduced, besides, the curing temperature is reduced, bioactive substances are loaded in hydrogel, the mixed bone cement is endowed with biological activity, the vertebral body is stabilized, the pain of a patient is relieved, and besides, local osteogenesis is promoted.

Description

technical field [0001] The invention relates to materials for vertebroplasty, in particular to a bone cement hydrogel composite material for vertebroplasty and a preparation method thereof. Background technique [0002] Vertebroplasty (PVP) is commonly used in the treatment of osteoporotic vertebral fractures, pathological vertebral fractures, and vertebral metastases due to its advantages of minimally invasiveness, effective stabilization of the vertebral body, and pain relief. Polymethyl methacrylate (PMMA) bone cement is currently the widely used bone cement material in PVP surgery. It has high strength and can be cured quickly to restore the strength and stiffness of the diseased vertebra. However, its main disadvantages in actual clinical application are as follows: 1) A large amount of heat is released during the polymerization process, and its maximum temperature exceeds the tolerance range of human tissues, reaching 80°C or even higher, resulting in necrosis of surro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/52A61L27/16A61L27/50A61L27/20C08B37/08
CPCA61L27/54A61L27/52A61L27/16A61L27/50A61L27/20C08B37/0072A61L2430/38A61L2300/232A61L2300/404A61L2300/412C08L33/12C08L5/08
Inventor 孙鑫金文杰李海燕张鑫
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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