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Preparation method of vitamin B12 microcapsule tablet

A B12 and vitamin technology, applied in microcapsule preparation, microsphere preparation, function of food ingredients, etc., can solve the problems of insufficient stability of microencapsulated products and single processing of microcapsule solution, and achieve large-scale production and stable solution. , The effect of good product quality

Pending Publication Date: 2021-11-26
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The conventional technology only uses a single wall material and a single core material when preparing the microcapsule solution, and the treatment of the microcapsule solution is relatively simple, and the microencapsulated product is not stable enough

Method used

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  • Preparation method of vitamin B12 microcapsule tablet
  • Preparation method of vitamin B12 microcapsule tablet
  • Preparation method of vitamin B12 microcapsule tablet

Examples

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preparation example Construction

[0026] a B vitamin 12 The preparation method of microcapsule tablet, this method comprises the following steps:

[0027] (1) Weigh 1g of pure vitamin B 12 Solid particles, added to the release trigger component (1:1 chitosan: aminoalkyl methacrylate copolymer), VB 12 The mass ratio (w / w) to the release trigger component is 1:20 to 1:25. After mixing, add it to deionized water, stir on a shaker for 10 minutes and mix well, so as to obtain VB 12 aqueous solution;

[0028] (2) Mix cellulose ether with zein, shellac, gluten, polylactic acid, and hydrophobic starch derivatives in equal proportions to prepare a hydrophobic polymer, and then mix with modified chitosan at a ratio of 1:8 to 1:10 Mix and dissolve in deionized water, and mix well to obtain a wall material aqueous solution;

[0029] (3) Vitamin B 12 The aqueous solution and the wall material aqueous solution are mixed at a ratio of 1:5 to 1:9, and then subjected to high-pressure homogenization treatment. The paramete...

Embodiment 1

[0032] Embodiment 1: A kind of vitamin B 12 The preparation method of microcapsule tablet is characterized in that, comprises the following steps: (1) take by weighing the pure product vitamin B of 1g 12 Solid particles, added to the release trigger component (1:1 chitosan: aminoalkyl methacrylate copolymer), VB 12 The mass ratio (w / w) to the release trigger component is 1:20, after mixing, add it to deionized water, stir on the shaker for 10min and mix well, so as to obtain VB 12 (2) Mix cellulose ether with zein, shellac, gluten, polylactic acid, and hydrophobic starch derivatives in equal proportions to prepare a hydrophobic polymer, and then mix it with modified chitosan at a ratio of 1:8 to dissolve In deionized water, mix uniformly to obtain wall material aqueous solution; (3) vitamin B 12 The aqueous solution and the wall material aqueous solution are mixed at a ratio of 1:5, and then subjected to high-pressure homogenization treatment. Carry out spray drying treatme...

Embodiment 2

[0033] Embodiment 2: A kind of vitamin B 12 The preparation method of microcapsule tablet is characterized in that, comprises the following steps: (1) take by weighing the pure product vitamin B of 1g 12 Solid particles, added to the release trigger component (1:1 chitosan: aminoalkyl methacrylate copolymer), VB 12 The mass ratio (w / w) to the release trigger component is 1:21. After mixing, add it to deionized water, stir on a shaker for 10 minutes and mix well, so as to obtain VB 12 (2) Mix cellulose ether with zein, shellac, gluten, polylactic acid, and hydrophobic starch derivatives in equal proportions to prepare a hydrophobic polymer, and then mix it with modified chitosan at a ratio of 1:8.5 to dissolve In deionized water, mix uniformly to obtain wall material aqueous solution; (3) vitamin B 12 The aqueous solution and the wall material aqueous solution are mixed at a ratio of 1:6, and then subjected to high-pressure homogenization treatment. Carry out spray drying tr...

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Abstract

The invention discloses a preparation method of a vitamin B12 microcapsule tablet, which belongs to the field of functional food processing. The method mainly comprises the following steps: (1) mixing vitamin B12 solid particles with a release triggering component, and adding the mixture into deionized water to prepare a vitamin B12 aqueous solution; (2) mixing a hydrophobic polymer and modified chitosan, dissolving in deionized water, and uniformly mixing to prepare a wall material aqueous solution; (3) mixing the aqueous solution of vitamin B12 with the aqueous solution of the wall material, and carrying out high-pressure homogenization treatment; (4) performing spray drying treatment; and (5) tabletting, sterilizing and packaging. A conventional microcapsule method is improved, the modified chitosan and the hydrophobic polymer are used as wall materials, and the vitamin B12 embedded microcapsule tablet is obtained through high-pressure homogenization and spray drying. The tablets prepared by the method are easy to store and good in solubility, and can be eaten by vegetarians and vitamin B12 lacking people.

Description

technical field [0001] The invention belongs to the field of functional food processing, and mainly relates to a vitamin B 12 Preparation method of microcapsule tablet. Background technique [0002] Vitamin B 12 Also known as cobalamin, it is a vitamin with a relatively complex chemical structure. The human body cannot synthesize it by itself, and its source is completely dependent on food (mainly animal protein) supply. Vitamin B 12 Its stability is mainly affected by light, heat, and pH of the solution, and various analogs will be generated during food processing. Currently, the vitamin B 12 Stability improvement research has become a hot spot in the field of cobalamin research at home and abroad. protect vitamin B 12 , prevent it from being destroyed during food processing, and increase vitamin B 12 Efficient utilization needs to be solved urgently. [0003] In general, microencapsulation is a viable approach to protect bioactive compounds and thereby increase the...

Claims

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Application Information

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IPC IPC(8): B01J13/04A23L33/15
CPCB01J13/043A23L33/15A23V2002/00A23V2200/30A23V2250/706A23V2250/511
Inventor 滕飞和铭钰吴长玲李礼佳张梦
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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