Frame type bone joint prosthesis, and preparation method and application thereof
A bone joint and frame-type technology, applied in the field of frame-type bone joint prosthesis and its preparation, can solve the problems of high risk and cumbersome operation, etc., and achieve the effect of prolonging the action time, simple operation, and promoting bone regeneration
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Embodiment 1
[0076] Example Frame bone joint prosthesis an embodiment of the invention provides
[0077] Frame bone joint prosthesis provided by the present embodiment as figure 1 , figure 2 , image 3 , Figure 4 with Figure 5 , In which figure 1 A frame-type structure of each bone joint prosthesis of FIG resolution; figure 2 Frame is a schematic structural shape bone joint prosthesis; image 3 A-A sectional view of a joint prosthesis to bone framed; Figure 4 Frame is a B-B sectional bone and joint prosthesis of FIG; Figure 5 C-C sectional view of FIG joint prosthesis is framed bone.
[0078]Frame bone prosthetic material according to the present embodiment may be made of titanium alloy, tantalum, polylactic acid, PEEK materials, materials used, preferred embodiments of the present embodiment is prepared using a titanium alloy material.
[0079] Frame bone joint prosthesis according to the present embodiment employs 2D prepared by printing, comprising in the upper three sections, the upper layer...
Embodiment 2
[0097] Recipe selection promoting regeneration of bone and joint hydrogel Example 2
[0098] The present embodiment uses the frame type titanium bone joint prosthesis provided in Example 1, respectively, according to different formulations of hydrogels into three groups, wherein the first group was the control group were GelMA hydrogel, the second group uses GelMA hydrogel + osteogenic agent group, the third group uses a hydrogel GelMA + + osteogenic microenvironment of bone regeneration additive groups, wherein the hydrogel is GelMA 5% GelMA hydrogel, osteoinductive agents include 1mg / ml zoledronic acid, 100mmol / L of β- glycerophosphate, 10 - 3 mol / L dexamethasone, vitamin C 500ug / ml of bone regeneration additives include bone morphogenic 3mg / ml protein generated BMP-2,30ug / ml fibroblast growth factor, vascular endothelial 3ug / ml growth factor, 30mg / ml lyophilized powder Prudential stem cells, and using 0.5% photoinitiator LAP, osteogenic vitro experiments. Each ...
Embodiment 3
[0099] Volume 3 embodiment hydrogel with autologous bone particles selected embodiments ratio
[0100] The present embodiment uses the frame type titanium bone joint prosthesis provided in Example 1, and using a third set of the hydrogel formulations as provided by Example 2, wherein the volume ratio of the hydrogel and autologous bone particles are selected to be 1: 0,1: 1,1: 2,1: 3 and 1: 4, the hydrogel investigated with autologous bone volume ratio of particles of different gel formulations covering effect of the surface of the prosthesis, the results shown in table 1 shown, respectively, wherein when the volume ratio of 1: 0 and 1: 2, a partial picture frame type of bone joint prosthesis after covering hydrogels such Figure 10 Indicated.
[0101] Table 1,
[0102]
[0103] As more autologous tissue regeneration could promote rapid healing. It is seen from Table 1, when only contain a hydrogel, although the gel covering solid, void-free residue, but the lack of autologous ti...
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Abstract
Description
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Application Information
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