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Immune globulin and lipopolysaccharide composite immunopotentiator

A technology of immunoglobulin and immune enhancer, which is applied in the field of animal blood immunoglobulin and placental lipopolysaccharide compound immune enhancer and its preparation field, and can solve the problem that the use, sales and report of lipopolysaccharide and immunoglobulin compound agent have not yet been found. To achieve the effect of strong immune synergism, significant economic benefits and good palatability

Pending Publication Date: 2021-12-10
河南省健达动保有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the existing immunoglobulin products are single products as immunomodulators, and there is no use, sales and reports about lipopolysaccharide and immunoglobulin complexes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A compound immune enhancer of animal blood immunoglobulin and placental lipopolysaccharide, which is composed of the following raw materials in parts by weight: pig blood immunoglobulin and pig placental lipopolysaccharide as main raw materials, added with sterile physiological saline and auxiliary materials, The specific formula is that every 100 mL contains 0.4 g of animal blood immunoglobulin; 0.5 g of placental lipopolysaccharide; 2 g of corn oligopeptide powder; 1 g of sodium alginate;

[0033] The animal blood immunoglobulin is obtained through the following extraction process steps:

[0034] (1) Collect fresh animal blood that has passed the quarantine and centrifuge at 3800r / min for 8 minutes, and discard the filter residue after centrifugation;

[0035] (2) Add NaCl and ammonium sulfate to the filtrate, add 20%% ammonium sulfate to 1L, stir with a stirrer for 30 minutes, then centrifuge at 3800r / min for 8 minutes, and discard the supernatant after centrifugatio...

Embodiment 2

[0052] A compound immune enhancer of animal blood immunoglobulin and placental lipopolysaccharide, which is composed of the following raw materials in parts by weight: sheep blood immunoglobulin and sheep placental lipopolysaccharide are the main raw materials, and sterile physiological saline and auxiliary materials are added. The specific formula is that every 100 mL contains 1 g of animal blood immunoglobulin; 1.0 g of placental lipopolysaccharide; 10 g of corn oligopeptide powder; 5 g of sodium alginate; the rest is supplemented by sterile normal saline, pH 8.0.

[0053] The animal blood immunoglobulin is obtained through the following extraction process steps:

[0054] (1) Collect fresh sheep blood that has passed the quarantine and centrifuge at 4000r / min for 10 minutes, and discard the filter residue after centrifugation;

[0055] (2) Add NaCl and ammonium sulfate to the filtrate, add 30% ammonium sulfate to 1L, stir with a stirrer for 30 minutes, then centrifuge at 400...

Embodiment 3

[0072] A compound immune enhancer of animal blood immunoglobulin and placental lipopolysaccharide, which is composed of the following raw materials in parts by weight: bovine blood immunoglobulin and bovine placental lipopolysaccharide as main raw materials, added with sterile physiological saline and auxiliary materials, The specific formula is that every 100 mL contains 0.7 g of animal blood immunoglobulin; 0.8 g of placental lipopolysaccharide; 6 g of corn oligopeptide powder; 3 g of sodium alginate; the rest is supplemented by sterile normal saline, pH 7.0.

[0073] The animal blood immunoglobulin is obtained through the following extraction process steps:

[0074] (1) Collect fresh bovine blood that has passed the quarantine and centrifuge at 3900r / min for 9 minutes, and discard the filter residue after centrifugation;

[0075] (2) Add NaCl and ammonium sulfate to the filtrate, add 25% ammonium sulfate to 1L, stir with a stirrer for 30 minutes, then centrifuge at 3900r / mi...

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PUM

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Abstract

The invention provides an animal blood immune globulin and placenta lipopolysaccharide composite immunopotentiator. The composite immunopotentiator is prepared by taking animal blood immune globulin and placenta lipopolysaccharide as main raw materials and adding sterile normal saline and auxiliary materials. A formula is that every 100 mL of the immunopotentiator contains 0.4-1 g of animal blood immune globulin, 0.5-1.0 g of placenta lipopolysaccharide, 2-10 g of corn oligopeptide powder, 1-5 g of sodium alginate, and the balance of the sterile normal saline. The composite immunopotentiator perfectly combines the animal blood immune globulin and the placenta lipopolysaccharide, so that the animal blood immune globulin and the placenta lipopolysaccharide exert a synergistic effect, and compared with existing similar products in the market, the composite immunopotentiator is relatively high in bioavailability, strong in immune synergistic effect, free of toxic and side effects and capable of promoting animal growth, improving the health state of animals, reducing the taking frequency and shortening the treatment course. The aim of reducing and replacing antibiotics is achieved, and the food safety of human beings is indirectly improved.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a composite immune enhancer of animal blood immunoglobulin and placental lipopolysaccharide and a preparation method thereof. Background technique [0002] Animal placental lipopolysaccharide is a mixture of biologically active polypeptides and nucleotides, which can transfer the cellular immune function of donor cells to recipient cells, non-specifically enhance general cellular immunity, and improve recipient immunity. Function, and safe and non-toxic, no drug residue, is a new type of immunomodulator. It is mainly used for the treatment of viral infections and autoimmune diseases. It can significantly increase the antibody titer and enhance the immune effect when used with vaccines. [0003] Immunoglobulin (IG) is a general term for antibody proteins that directly participate in the immune response. Animal blood contains a large amount of immunoglobulin, which is the main substa...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61K47/42A61K47/36A61P37/04C07K16/06C07K1/36C07K1/34C07K1/30C12P19/14C12P19/04A61K31/739
CPCA61K39/395A61K31/739A61K47/42A61K47/36A61P37/04C07K16/065C12P19/14C12P19/04A61K2039/505A61K2300/00
Inventor 杨得富
Owner 河南省健达动保有限公司