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Laminarin compound with intestinal barrier repairing effect and preparation method thereof

A technology of lamina polysaccharides and polysaccharides, which is applied in the field of lamina polysaccharides and their preparation, can solve the problems of severe toxicity and side effects, and achieve the effects of improving integrity, maintaining stability, and improving intestinal fibrosis

Pending Publication Date: 2021-12-14
SHANTOU MEIHENG TETRA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, inflammatory bowel disease is mainly treated with inflammatory drugs, immunosuppressants, and biological drugs, but these drugs have relatively large toxic and side effects

Method used

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  • Laminarin compound with intestinal barrier repairing effect and preparation method thereof
  • Laminarin compound with intestinal barrier repairing effect and preparation method thereof
  • Laminarin compound with intestinal barrier repairing effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] A preparation method of lamina polysaccharides, comprising the following steps:

[0056] (1) Add laminarin and methyl isonicotinate to toluene, wherein: the mass volume ratio of laminarin and methyl isonicotinate is 1g:10mL, the temperature is 130°C, fill with nitrogen as a protective gas, stir and reflux for 36 hours , and then rotary evaporated at 70°C to obtain a solid product;

[0057] (2) Add the solid product obtained in step (1) into dimethyl sulfoxide to dissolve, wherein: the mass volume ratio of the solid product to dimethyl sulfoxide is 1g: 15mL, stir evenly at room temperature, and dissolve liquid;

[0058] (3) Add gamma-butyrolactone into dimethyl sulfoxide, wherein: the volume ratio of gamma-butyrolactone and dimethyl sulfoxide is 1:4, and then add the solution prepared in step (2) dropwise solution, mixed evenly to obtain a reaction solution;

[0059] (4) Stir the reaction solution prepared in step (3) at 90°C for 36 hours, and pour it into acetone at ...

Embodiment 2

[0063] A preparation method of lamina polysaccharides, comprising the following steps:

[0064] (1) Add laminarin and methyl isonicotinate to toluene, wherein: the mass volume ratio of laminarin and methyl isonicotinate is 1g:20mL, the temperature is 110°C, fill with nitrogen as a protective gas, stir and reflux for 54 hours , and then rotary evaporated at 60°C to obtain a solid product;

[0065] (2) Add the solid product obtained in step (1) into dimethyl sulfoxide to dissolve, wherein: the mass volume ratio of the solid product to dimethyl sulfoxide is 1g: 5mL, stir evenly at room temperature, and dissolve liquid;

[0066] (3) Add gamma-butyrolactone into dimethyl sulfoxide, wherein: the volume ratio of gamma-butyrolactone and dimethyl sulfoxide is 1:10, and then add the solution prepared in step (2) dropwise solution, mixed evenly to obtain a reaction solution;

[0067] (4) Stir the reaction solution prepared in step (3) at 70°C for 60 hours, and pour it into acetone at ...

Embodiment 3

[0071] A preparation method of lamina polysaccharides, comprising the following steps:

[0072] (1) Add laminarin and methyl isonicotinate to toluene, wherein: the mass volume ratio of laminarin and methyl isonicotinate is 1g:15mL, the temperature is 120°C, fill with nitrogen as a protective gas, stir and reflux for 48 hours , and then rotary evaporated at 65°C to obtain a solid product;

[0073] (2) Add the solid product obtained in step (1) into dimethyl sulfoxide to dissolve, wherein: the mass volume ratio of the solid product to dimethyl sulfoxide is 1g: 10mL, stir evenly at room temperature, and dissolve liquid;

[0074] (3) Add γ-butyrolactone into dimethyl sulfoxide, wherein: the volume ratio of γ-butyrolactone and dimethyl sulfoxide is 1:5, and then add the solution prepared in step (2) dropwise solution, mixed evenly to obtain a reaction solution;

[0075] (4) Stir the reaction solution prepared in step (3) at 80°C for 48 hours, and pour it into acetone at 4°C afte...

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Abstract

The invention belongs to the technical field of biological medicine, and particularly discloses a laminarin compound with an intestinal barrier repairing effect and a preparation method and application of the laminarin compound. The laminarin compound is a laminarin modified with a carboxylic acid group. The preparation method comprises the following steps: adding laminarin, pyridine and / or pyridine derivatives into an organic solvent, reacting, and drying to obtain a solid product; adding the solid product into an organic solvent for dissolving to obtain a dissolved solution; adding an organic matter containing a carboxylic acid group into an organic solvent, then adding the dissolving solution, and mixing to obtain a reaction solution; and heating the reaction liquid, cooling, pouring into an organic solvent, and drying to obtain the laminarin compound. The pyridine laminarin carboxylate modified by carboxylic acid groups has a good effect in the aspect of intestinal barrier repair, and not only can improve intestinal fibrosis, but also can regulate intestinal flora imbalance.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a laminarin compound with intestinal barrier repairing function, a preparation method and application thereof. Background technique [0002] With the continuous improvement of people's material living standards, people have more and more choices in diet. Due to the widespread popularization and abuse of fast food and food additives, people's diet structure and habits are constantly changing. High-salt, high-sugar, high-fat food Food is appearing more and more on the dining table. Such a change in dietary structure has also caused many intestinal diseases, which seriously threaten the health and stability of the intestinal tract, and then affect people's normal life and work. According to epidemiological studies, inflammatory bowel disease is mainly caused by unreasonable diet structure, and inflammatory bowel disease is a group of gastrointestinal diseases charac...

Claims

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Application Information

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IPC IPC(8): C08B37/18A61P1/00
CPCC08B37/00Y02A50/30
Inventor 张杰良李云峰余标
Owner SHANTOU MEIHENG TETRA BIOTECH CO LTD
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