Starch-based capsule coat as well as preparation method and application thereof

A starch-based, capsule-based technology, which is applied in application, capsule delivery, and pharmaceutical formulations, can solve problems such as poor use effect, difficult processing and molding, and poor plasticity of starch.

Active Publication Date: 2021-12-28
NANJING UNIV OF FINANCE & ECONOMICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the most widely used plant-based capsule coating is starch capsule coating. Its raw materials are derived from natural plants, which are rich, safe, cheap and stable in performance. The brittleness can be reduced by adding a plasticizer, but the mechanical strength is not enough, so that the performance of the prepared capsule coat is not as good as that of the gelatin capsule coat, and the use effect is poor

Method used

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  • Starch-based capsule coat as well as preparation method and application thereof
  • Starch-based capsule coat as well as preparation method and application thereof

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preparation example Construction

[0033] The present invention also provides the preparation method of the starch-based capsule coat described in the above technical scheme, comprising the following steps:

[0034] (1) mixing anion / cation starch, natural product and water to obtain an initial mixture;

[0035] (2) Melting and extruding the initial mixture obtained in the step (1) to obtain a semi-finished product;

[0036] (3) The semi-finished product obtained in the step (2) is subjected to thermocompression molding or blister molding to obtain a starch-based capsule coat;

[0037] When the raw material of the starch-based capsule coat includes a plasticizer, the plasticizer is added in step (1).

[0038] The invention mixes anion / cation starch, natural product and water to obtain primary mixture.

[0039] In the present invention, the operation of mixing the anion / cation starch, natural products and water is preferably mixed in a high-speed mixer; the mixing speed is preferably 100-2000rpm, more preferabl...

Embodiment 1

[0050] The starch-based capsule coat is prepared from the raw materials in the following mass percentages:

[0051] Carboxymethyl starch 50wt%, chitosan 30wt%, plasticizer glycerin 10wt% and the water of remainder;

[0052] The preparation method of described starch-based capsule coat, is the following steps:

[0053] (1) Carboxymethyl starch, chitosan, glycerin and water are placed in the high-speed mixer according to the corresponding proportion, and are preliminarily blended for 5 minutes at a speed of 500 rpm to obtain the initial mixture;

[0054] (2) Add the primary mixture obtained in the step (1) to a twin-screw extruder at a feed rate of 25rpm for melt extrusion. The temperatures in each zone of the extruder are respectively: 40°C in the first zone and 80°C in the second zone. ℃, 120°C in the third zone, 120°C in the fourth zone, 120°C in the fifth zone, 100°C in the sixth zone, 80°C in the seventh zone, 80°C in the die head, and the screw speed is 150rpm, and a 0.15...

Embodiment 2

[0057] The starch-based capsule coat is prepared from the raw materials in the following mass percentages:

[0058] Starch succinate 65wt%, polylysine 20wt%, plasticizer polyethylene glycol 3wt% and the water of remainder;

[0059] The preparation method of described starch-based capsule coat, is the following steps:

[0060] (1) Starch succinate, polylysine, polyethylene glycol and water are placed in a high-speed mixer in corresponding proportions, and initially blended at a speed of 1000 rpm for 3 minutes to obtain an initial mixture;

[0061] (2) Add the primary mixture obtained in the step (1) to a twin-screw extruder at a feed rate of 30rpm for melt extrusion. The temperatures in each zone of the extruder are respectively: 40°C in the first zone and 80°C in the second zone. ℃, 150℃ in the third zone, 120℃ in the fourth zone, 120℃ in the fifth zone, 100℃ in the sixth zone, 90℃ in the seventh zone, 90℃ in the die head, and the screw speed is 200rpm, and a 0.1mm thick shee...

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Abstract

The invention provides a starch-based capsule coat, which is prepared from the following raw materials in percentage by mass: 40-70wt% of anionic/cationic starch, 20-50wt% of a natural product, less than or equal to 10wt% of a plasticizer and the balance of water; the charge of the natural product is opposite to that of the anionic/cationic starch; the natural product comprises at least one of chitosan, carboxymethyl cellulose, sodium alginate, polylysine, dextran, dextran sodium sulfate and sulfonated cellulose. According to the invention, the anionic/cationic starch with charges and the natural product with opposite charges are compounded, the polyelectrolyte material can be formed under the electrostatic interaction, the acting force of the electrostatic interaction of the polyelectrolyte material is far stronger than that of hydrogen bonds and intermolecular interaction, and the polyelectrolyte material has an aggregation effect, so that the starch-based capsule coat has excellent mechanical properties.

Description

technical field [0001] The invention relates to the technical field of natural polymer materials, in particular to a starch-based capsule coat and a preparation method and application thereof. Background technique [0002] Capsule coat is a widely used filling material for medicines, food and health care products. Currently, capsule coatings are mainly divided into gelatin capsule coatings and plant capsule coatings. Among them, gelatin is a by-product of slaughtering animals, which not only causes killing and conflicts of religious beliefs, but also is expensive and prone to deterioration due to temperature. Therefore, plant-based capsule coats are currently widely researched and developed due to their advantages such as stable performance, low price, and "vegetarian" food. Among them, the most widely used plant-based capsule coating is starch capsule coating. Its raw materials are derived from natural plants, which are rich, safe, cheap and stable in performance. The bri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/38A61K47/34A61K8/11A61K8/73A61K8/88A61Q19/00A23P10/30A23P30/20
CPCA61K9/4816A61K47/36A61K47/38A61K47/34A61K8/11A61K8/732A61K8/731A61K8/736A61K8/733A61K8/88A61K8/73A61Q19/00A23P10/30A23P30/20A61K2800/56A61K2800/10
Inventor 孟令晗张林华汤洋唐鑫宇高成成汤晓智
Owner NANJING UNIV OF FINANCE & ECONOMICS
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