Paraquat composition containing cyclodextrin derivative, and application of paraquat composition in attenuation of mammals
A mammal and paraquat technology, applied in the field of pesticides, can solve the problems of interfering with the efficacy of the drug, the curative effect cannot be accurately controlled, and the paraquat poisoning cannot be effectively prevented in advance, and the effect of improving the herbicidal effect can be achieved.
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Embodiment 1
[0040] Embodiment 1: the preparation of paraquat composition
[0041] Preparation method 1: Mix paraquat and cyclodextrin derivatives according to the ratio, add 1000ml of water to fully mix and dissolve, spin dry the water under reduced pressure and dry to obtain the paraquat composition.
[0042] According to the preparation method 1, the composition is prepared according to the ratio of the cyclodextrin derivative and the paraquat mother drug in the following table 1. The serial number of the prepared paraquat composition, the type of the cyclodextrin derivative, and the dosage of the paraquat mother solution are shown in the following table 1.
[0043] Table 1 Composition of cyclodextrin derivatives and paraquat
[0044]
[0045] Compositions HE01-HE04 were prepared according to the above-mentioned cyclodextrin derivative species, the quality of the attenuator and the quality of the mother liquor of paraquat, and no other auxiliaries were added during the preparation pr...
Embodiment 2 100
[0046] Example 2 Toxicity Test of Paraquat Compositions to Mammals
[0047] The paraquat compositions HE01-HE04 in Table 1 were diluted with sterile aqueous solution to a mass concentration of paraquat of 0.5%, and used as experimental samples for future use. Set up a control group, the control group number is HE05, and the control group is to dilute 42wt% paraquat parent drug to a paraquat mass concentration of 0.5%, which is used as a control sample for later use. Set up a blank group, the blank group number is HE06, use sterile water as the blank group, and the sterile water as the blank sample.
[0048] The above-mentioned prepared samples were subjected to animal toxicity test respectively, and three parallel groups were set up for each sample test, and each parallel group consisted of 3 mice, and each mouse was injected with 600 μL of the solution into the stomach. Then observe the number of dead mice and the number of surviving mice every day, and count the number of s...
Embodiment 3
[0052] The herbicidal effect of embodiment 3 paraquat composition
[0053] The above paraquat composition was diluted to the multiples shown in Table 3 below for testing to verify the herbicidal effect of the paraquat composition added with cyclodextrin derivatives. Firstly, the paraquat water solution of HE05 was used to carry out the concentration gradient test, and the paraquat of the control paraquat composition HE05 was diluted to 1000ppm (1mg / ml), 2000ppm (2mg / ml) and 5000ppm (5mg / ml) in the forest The weeding experiment was carried out in the weeds in the forest (the average height of the weeds in the forest is 20cm), the application time is at noon on a sunny day, three parallels are set for each concentration, and each parallel is set to 1 square meter, and the weeds are counted 15 days after the application. Grass Mortality.
[0054] Among them, the calculation method of weed mortality rate (also called weed control rate or weed control effect) is:
[0055]
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