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Sulfated schizophyllan, preparation method thereof and application of sulfated schizophyllan in cosmetics

A technology of schizophyllan and sulfation, which is applied in the field of sulfation of schizophyllan and its preparation, can solve the problems of low solubility, low yield of carboxymethylated products, and low yield, and achieve enhanced moisturizing activity Effect

Active Publication Date: 2022-02-08
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] During the derivatization modification of schizophyllan, the yield of carboxymethylated products is low because some schizophyllan has not been substituted successfully or the degree of substitution is too low And the problem of low solubility; problems such as low degree of substitution or low yield also exist in the sulfation modification technology of existing polysaccharides. Sulfated schizophyllan with good properties and good moisturizing activity and preparation method thereof

Method used

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  • Sulfated schizophyllan, preparation method thereof and application of sulfated schizophyllan in cosmetics
  • Sulfated schizophyllan, preparation method thereof and application of sulfated schizophyllan in cosmetics
  • Sulfated schizophyllan, preparation method thereof and application of sulfated schizophyllan in cosmetics

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Experimental program
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Embodiment 1

[0045] Take 2g of dried Schizophyllan, put it into a screw-necked Erlenmeyer flask, add 300mL of DMF, and infiltrate in a dry environment for 12h. Add 4 g of pyridine sulfur trioxide, react in a water bath at 70° C. for 2 h, and stir at 700 rpm. Then quickly lower the temperature to 20°C, add concentrated sulfuric acid with 1 times the mass of dry Schizophyllan, and continue the reaction for 10 minutes. After the reaction, add 400mL pre-cooled distilled water, adjust the pH value of the solution to 7.5 with 2mol / L NaOH, add 95% ethanol until the final concentration of ethanol is 75% for alcohol precipitation, polysaccharides are redissolved in distilled water, and the molecular weight cut-off It was dialyzed for 72 hours with a 30kD ultrafiltration membrane, concentrated under reduced pressure at 50°C, and freeze-dried to obtain sulfated schizophyllan (S-SPG1). figure 2 It is the infrared spectrogram of embodiment 1 product S-SPG1. compared to figure 1 , S-SPG1 has new cha...

Embodiment 2

[0047] Take 6g of dried Schizophyllan, put it into a screw-necked Erlenmeyer flask, add 960mL DMF, and infiltrate it in a dry environment for 14h. Add 24.0 g of pyridine sulfur trioxide, react in a water bath at 60° C. for 1 h, and stir at 900 rpm. Then quickly lower the temperature to 10°C, add concentrated sulfuric acid twice the mass of the dry Schizophyllan, and continue the reaction for 40 minutes. After the reaction, add 1200mL pre-cooled distilled water, adjust the pH value of the solution to 7.0 with 4mol / L NaOH, add 95% ethanol until the final concentration of ethanol is 60% for alcohol precipitation. It was dialyzed for 84 hours with a 5kD ultrafiltration membrane, concentrated under reduced pressure at 45°C, and freeze-dried to obtain sulfated schizophyllan (S-SPG2). The infrared characterization of S-SPG2 is shown in the figure below. image 3 It is the infrared spectrogram of embodiment 2 product S-SPG2. compared to figure 1 , S-SPG2 at 1260~1210cm -1 , 840~8...

Embodiment 3

[0049] Take 3g of dried Schizophyllan, put it into a screw-necked Erlenmeyer flask, add 540mL DMF, and infiltrate it in a dry environment for 8h. Add 18.0 g of pyridine sulfur trioxide, react in a water bath at 80° C. for 4 h, and stir at 800 rpm. Then rapidly lower the temperature to 0°C, add concentrated sulfuric acid three times the mass of the dried Schizophyllan, and continue the reaction for 30 minutes. After the reaction, add 600mL pre-cooled distilled water, adjust the pH value of the solution to 8.0 with 2.5mol / L NaOH, add 95% ethanol until the final concentration of ethanol is 80% for alcohol precipitation, and redissolve the polysaccharide in distilled water. Dialyzed by a 3kD ultrafiltration membrane for 96 hours, concentrated under reduced pressure at 40°C, and freeze-dried to obtain sulfated schizophyllan (S-SPG3). Figure 4 It is the infrared spectrogram of embodiment 3 product S-SPG3. compared to figure 1 , S-SPG2 is also at 1260~1210cm -1 , 840~810cm -1 ,...

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Abstract

The invention discloses sulfated schizophyllan, a preparation method of the sulfated schizophyllan and application of the sulfated schizophyllan in cosmetics. The sulfated schizophyllan is prepared by the following steps: reacting infiltrated schizophyllan with pyridine sulfur trioxide, reducing the temperature to 0-20 DEG C, adding concentrated sulfuric acid to continuously react, dissolving a reaction product by distilled water, adjusting the pH value of the solution, carrying out alcohol precipitation, redissolving, dialyzing, concentrating under reduced pressure and drying, thereby obtaining the sulfated schizophyllan. The addition amount of the pyridine sulfur trioxide is controlled to be 2-6 times of the mass of the schizophyllan, the reaction temperature of the schizophyllan and the pyridine sulfur trioxide is 50-80 DEG C, and the reaction time is 1-4 hours; the addition amount of the concentrated sulfuric acid is controlled to be 1-3 times of the mass of the schizophyllan, and the continuous reaction time is 10-40 minutes. The yield of the sulfated schizophyllan prepared by the method is high and is 90-200%, the substitution degree of the product is 1.6-2.0, and the product is high in solubility and does not need to be dissolved by heating.

Description

technical field [0001] The invention relates to a sulfated schizophyllan, in particular to a sulfated schizophyllan, its preparation method and its application in cosmetics. Background technique [0002] The skin is the first barrier of the human body and plays an irreplaceable role in protecting the body's moisture. The epidermis of the skin acts as a barrier, mainly to prevent moisture from escaping and to protect its structure from damage. In order to maintain good elasticity, moisture and moisturization of the skin, generally speaking, a water content of 10% to 20% is required. Therefore, maintaining skin moisture is a major research direction of skin care cosmetics. And as consumers pay more attention to moisturizing their own skin, the demand for skin care products with good moisturizing effect continues to increase. [0003] Schizophyllan is a neutral exopolysaccharide secreted by Schizophyllum fungi. Schizophyllan is a β-glucan connected by β-(1-3) glycosidic bon...

Claims

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Application Information

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IPC IPC(8): C08B37/02A61K8/73A61Q19/00
CPCC08B37/0024A61K8/73A61Q19/00
Inventor 郑必胜贺子倩郭朝万伍磊胡露裴运林
Owner SOUTH CHINA UNIV OF TECH
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