Composite hydrogel for promoting tendon-bone healing as well as preparation method and application thereof

A composite hydrogel and tendon-bone technology, applied in the field of surgical materials, can solve problems such as heterotopic ossification and loss of active ingredients, and achieve the effects of promoting bone regeneration and cartilage regeneration, promoting cell proliferation, and convenient operation

Active Publication Date: 2022-02-15
SHANGHAI SIXTH PEOPLES HOSPITAL
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing biological factor or cell injection therapy, the local effective components are lost due to the diffusion of factors or cells in the joint, and the escaped factors or cells can also cause adverse reactions such as heterotopic ossification

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composite hydrogel for promoting tendon-bone healing as well as preparation method and application thereof
  • Composite hydrogel for promoting tendon-bone healing as well as preparation method and application thereof
  • Composite hydrogel for promoting tendon-bone healing as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] This embodiment provides a composite hydrogel for promoting tendon-bone healing of old rotator cuff injuries, and its preparation method comprises the following steps:

[0036] 1. NH 2 -Synthesis of BGs

[0037] Modulation of bioactive glass by sol-gel method. Briefly, 5.6 g of cetyltrimethylammonium bromide was dissolved in 25 mL of ddH 2 In a mixed solution of O and 80mL ethanol, heat to 40°C and stir continuously until completely dissolved. Ammonia water 9.4mL, TEOS (tetraethyl orthosilicate) 15.23mL, TEP (triethyl phosphate) 1.58mL were added successively, and stirred for 30min. Add 9.62g of calcium nitrate and stir for 3 hours, and then centrifuge to separate the white precipitate from the glass sol. Finally, it was dried in an oven for 24 hours, and then sintered in a muffle furnace (550°C, 6 hours) to obtain BGs products. Add 6 g of prepared bioactive glass into 3 ml of double distilled water (ddH 2 O) and 200ml of ethanol in the mixture. After ultrasonic ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
phase transition temperatureaaaaaaaaaa
Login to view more

Abstract

The invention provides a composite hydrogel for promoting tendon-bone healing as well as a preparation method and the application thereof.The preparation method includes the steps that the surfaces of nanoscale bioglass particles are subjected to amino modification, kartogenin small molecules are grafted through amidation reaction, the materials are mixed with injectable temperature-sensitive hydrogel synthesized by methyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone and sodium chloride; and the composite hydrogel is prepared. The composite hydrogel can effectively solve the two major problems of bone loss and cartilage loss confronted by old rotator cuff injury, and is in a viscous liquid state at room temperature and gelling in an environment of more than 35 DEG C for 30 seconds, that is, the composite hydrogel can be gelling in a short time after being injected into a body, release drugs in situ and induce cell differentiation. Due to the application of the injectable temperature-sensitive system, the operation is very convenient, and the purpose of in-situ gelling and medicine release can be achieved. A new idea can be provided for clinically repairing old rotator cuff injury, and meanwhile bone regeneration and cartilage regeneration of a tendon-bone interface are promoted.

Description

technical field [0001] The invention relates to the technical field of surgical materials, in particular to a composite hydrogel for promoting tendon-bone healing, its preparation method and application. Background technique [0002] The rotator cuff, also known as the rotator cuff, is a group of tendon complexes wrapped around the humeral head. The front of the humeral head is the subscapularis tendon, the upper part is the supraspinatus tendon, and the rear is the infraspinatus tendon and teres minor tendon. The tuberosity and the border of the anatomical neck of the humerus, the inner surface is closely connected with the joint capsule, and the outer surface is the subdeltoid bursa. The movement of these tendons causes the shoulder joint to rotate internally, externally, and elevate, but more importantly, these tendons will The humeral head stabilizes on the glenoid and plays an extremely important role in maintaining the stability and movement of the shoulder joint. [...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/16A61L27/10A61L27/50A61L27/52A61L27/54
CPCA61L27/20A61L27/16A61L27/10A61L27/50A61L27/52A61L27/54A61L2430/10A61L2430/02A61L2430/06A61L2400/06A61L2300/412C08L39/06C08L29/04C08L1/02
Inventor 黄楷朱同贺赵金忠徐俊杰蒋佳
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap