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Direct vat set fermentation inoculant for relieving constipation-type irritable bowel syndrome and preparation method and application thereof

A technology for irritable bowel syndrome and fermentative inoculum, applied in microorganism-based methods, biochemical equipment and methods, bacteria used in food preparation, etc., can solve problems such as side effects, constipation recurrence, etc. Growth and stability-enhancing effects

Pending Publication Date: 2022-02-15
上海益维尔康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The drug therapy disclosed in the prior art has a good therapeutic effect on constipation-predominant irritable bowel syndrome. However, the drug therapy often leads to a certain degree of dependence. Once the patient stops using the drug, the constipation often recurs, and the drug therapy may Some side effects, such as headache, abdominal pain, diarrhea and cardiovascular disease, etc.

Method used

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  • Direct vat set fermentation inoculant for relieving constipation-type irritable bowel syndrome and preparation method and application thereof
  • Direct vat set fermentation inoculant for relieving constipation-type irritable bowel syndrome and preparation method and application thereof
  • Direct vat set fermentation inoculant for relieving constipation-type irritable bowel syndrome and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0067] This example provides a direct-injection fermented bacterial agent for alleviating constipation-type irritable bowel syndrome, which includes 30 parts of Streptococcus thermophilus ST81 fermented product, 1.5 parts of Lactobacillus bulgaricus LB42 fermented product, lactobacillus 2.5 parts of Fidobacterium BLa80 fermentation product, 12.5 parts of trehalose, 4 parts of maltodextrin, 1 part of β-cyclodextrin, 3 parts of sucrose, 1.5 parts of glycerin, 0.05 parts of mannitol and 0.2 parts of Tween-80. Among them, the number of live bacteria of Bifidobacterium lactis BLa80 in the direct-injection fermented bacterial agent for relieving constipation-type irritable bowel syndrome was 1×10 11 cfu / g.

[0068] Its preparation method is as follows:

[0069] (1) Inoculate the Bifidobacterium lactis BLa80 preserved in the glycerol tube in the MRS liquid medium at a ratio of 2%, culture it statically at 37°C for 22 hours, and activate it for 3 generations. The activated seeds wer...

Embodiment 2

[0074] This example provides a direct-injection fermented bacterial agent for alleviating constipation-type irritable bowel syndrome, which includes 25 parts of Streptococcus thermophilus ST81 fermented product, 2 parts of Lactobacillus bulgaricus LB42 fermented product, lactobacillus 2.5 parts of Mycobacterium BLa80 fermentation product, 14 parts of trehalose, 8 parts of maltodextrin, 1.5 parts of β-cyclodextrin, 2 parts of sucrose, 2.2 parts of glycerin, 0.25 parts of Tween-800 and 0.05 parts of mannitol.

[0075] Its preparation method is as follows:

[0076] (1) Streptococcus thermophilus ST81 stored in glycerol tubes was inoculated into MRS liquid medium at a ratio of 2%, cultured statically at 37°C for 22 hours, and activated for 3 generations. Inoculate the activated seeds into a fermenter with 2% inoculum, incubate at pH 5.5, 37°C for 11 hours, collect the bacterial solution and centrifuge at 10,000 r / min for 10 minutes, discard the supernatant, collect the bacterial s...

Embodiment 3

[0081] This example provides a direct-injection fermented bacterial agent for alleviating constipation-type irritable bowel syndrome, which includes 32 parts of Streptococcus thermophilus ST81 fermented product, 1.5 parts of Lactobacillus bulgaricus LB42 fermented product, lactobacillus 2.5 parts of Mycobacterium BLa80 fermentation product, 13 parts of trehalose, 3 parts of maltodextrin, 1.5 parts of β-cyclodextrin, 2 parts of sucrose, 0.01 part of mannitol, 1 part of glycerol and 0.2 parts of Tween-80.

[0082] Its preparation method is as follows:

[0083] (1) Lactobacillus bulgaricus LB42 preserved in glycerol tubes was inoculated in MRS liquid culture medium at a ratio of 2%, cultured statically at 37°C for 22 hours, and activated for 3 generations. Inoculate the activated seeds into a fermenter with 2% inoculum, incubate at pH 5.5, 37°C for 11 hours, collect the bacterial solution and centrifuge at 10,000 r / min for 10 minutes, discard the supernatant, collect the bacteria...

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Abstract

The invention relates to a direct vat set fermentation inoculant for relieving constipation type irritable bowel syndrome as well as a preparation method and application of the direct vat set fermentation inoculant. The direct vat set fermentation inoculant for relieving constipation type irritable bowel syndrome comprises a streptococcus thermophilus ST81 fermentation product, a lactobacillus bulgaricus LB42 fermentation product, a bifidobacterium lactis BLa80 fermentation product and a protective agent. The bifidobacterium lactis BLa80 plays a key role in regulating intestinal health and relieving constipation-type irritable bowel syndrome, and is combined with the streptococcus thermophilus ST81 and the lactobacillus bulgaricus LB42, so that on one hand, three florae are mutually promoted to facilitate the proceeding of a fermentation process and promote the growth of beneficial florae, and on the other hand, the three florae are mutually matched, so the fermented food has the significant synergistic effect on regulating the intestinal flora and relieving the constipation-type irritable bowel syndrome, and the prepared fermented food can improve the symptoms such as constipation, abdominal pain and the like, make the defecation smoother, and effectively relieve the constipation-type irritable bowel syndrome.

Description

technical field [0001] The invention belongs to the technical field of food processing, and relates to a direct-injection fermented bacterial agent and its preparation method and application, in particular to a direct-injected fermented inocula for alleviating constipation-type irritable bowel syndrome, its preparation method and application. Background technique [0002] Irritable bowel syndrome (IBS) is a group of persistent or intermittent episodes characterized by abdominal pain, bloating, changes in bowel habits and / or stool characteristics, and the lack of gastrointestinal structural and biochemical abnormalities Dysfunctional diseases. Irritable bowel syndrome with constipation (IBS-C) is one of the more common types of IBS. Patients will experience a series of gastrointestinal symptoms, such as abdominal pain, abdominal distension, abdominal discomfort, etc., and may also be accompanied by psychological problems such as anxiety and depression. At present, drug ther...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A23C9/123A23L11/50A23L33/00C12R1/46C12R1/225C12R1/01
CPCC12N1/20A23L11/50A23C9/123A23C9/1238A23L33/00A23V2002/00A23V2400/123A23V2400/249A23V2400/531A23V2200/32A23V2250/5024A23V2250/5072A23V2250/5116
Inventor 方曙光董瑶汪欣朱建国
Owner 上海益维尔康生物科技有限公司
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