Ophthalmic compositions
An ophthalmic composition, polymer technology, applied in or can be combined with the existing field, can solve the problems of patient compliance, time-consuming, troublesome, etc.
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example 1
[0092] Terpolymer-Poly(PEG 200 Synthesis of MA-co-MPC-co-VPBA) Terpolymer
[0093] About 1.011 g of VPBA was dissolved in 25.0 g of PrOH to obtain a VPBA solution, which was introduced through a syringe equipped with a 5 μm nylon filter into a 2 Inlet, overhead stirrer, thermocouple, condenser and bubbler in a 500 mL reactor. About 12.278g of PEG 200 MA was dissolved in 20.0 g DI water, poured into the reactor and rinsed with an additional 15.0 g DI water. About 6.714 g of MPC was dissolved in 20.0 g DI water, poured into the reactor and rinsed with an additional 15.0 g DI water. About 00693 g of AAPH was dissolved in 5.0 g deionized water, poured into the reactor and rinsed with an additional 2 x 5.0 g deionized water, followed by 5.0 g deionized water and 65.0 g n-propanol. Approximately 3.65 mL of mercaptoethanol (βME) solution (0.274 g βME in 100 mL of DI water) was added with a micropipette.
[0094] The reaction solution was purged with nitrogen (200 mL / min) for 30 ...
example 2
[0100] Synthesis of terpolymers
[0101] Poly (MPC 0.4 -co-NVP 0.5 -co-VPBA 0.1 )
[0102] In a 20 ml vial, 1.18 g (4 mmol) of MPC, 0.556 g (5 mmol) of NVP and 0.148 g (1 mmol) of VPBA were added and 10 ml of ethanol, 1.64 mg (0.01 mmol) of vazo64 were added. Nitrogen was gently bubbled into the solution for 5 min to eliminate oxygen and the vial was then sealed. Polymerization was carried out at 60°C for 6 hours. After cooling the vial, the contents were poured into a large mixture of diethyl ether and chloroform (8 / 2 by volume) to eliminate any remaining monomer and precipitate polymer. The precipitate was filtered off using a glass filter and dried under vacuum.
[0103] Poly (MPC 0.6 -co-BMA 0.3 -co-VPBA 0.1 )
[0104] In a 20 ml vial, 1.77 g (6 mmol) of MPC, 0.426 g (3 mmol) of BMA and 0.148 g (1 mmol) of VPBA were added and 10 ml of ethanol, 1.64 mg (0.01 mmol) of vazo64 were added. Nitrogen was gently bubbled into the solution for 5 min to eliminate o...
example 3
[0114] Synthesis of terpolymers
[0115]2-methacryloyloxyethylphosphorylcholine (MPC) (Mw=295.27), 4-vinylphenylboronic acid (VPBA, Mw=147.97), and optionally a third monomer (methyl Add n-butyl acrylate (BMA, Mw = 142.20) or di(ethylene glycol) methyl ether methacrylate (DGMEMA, Mw = 188.22), ethanol and DI water to a 1L jacketed reactor in the amounts shown in Table 8. Degas the solution at a nitrogen flow rate of 250 mL / min for 30 minutes. Dissolve Vazo-56 in 20 to 30 g of DI water. Degas the initiator solution at a nitrogen flow rate of about 50 mL / min in an additional funnel Gas for 30 minutes. The solution was heated in the reactor to 49° C. The initiator solution was added and the solution temperature was maintained for 16 hours.
[0116] purification:
[0117] The post-reaction solution was diluted to about 10% solids with DI water. The solution from the synthesis step was filtered through a course-fritted filter. The solution was filtered to 7.5%-5.0% solids for p...
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