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Method for determining contents of multi-index components in Tongtian oral liquid

A measurement method and technology of oral liquid, applied in measuring devices, separation of materials, analysis of materials, etc., can solve problems such as inability to evaluate the quality of Tongtian oral liquid, large formulations of Tongtian oral liquid, complex chemical components, etc., and achieve low price and method Simple and highly sensitive results

Pending Publication Date: 2022-02-25
鉴甄检测技术(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the relatively large formula of Tongtian Oral Liquid and the complex chemical composition, the above method cannot effectively evaluate the quality of Tongtian Oral Liquid and is not practical enough

Method used

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  • Method for determining contents of multi-index components in Tongtian oral liquid
  • Method for determining contents of multi-index components in Tongtian oral liquid
  • Method for determining contents of multi-index components in Tongtian oral liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The present embodiment provides a method for determining the content of multi-index components in Tongtian Oral Liquid, which includes the following steps:

[0051] (1) Preparation of reference substance solution: Take appropriate amount of 18 kinds of reference substances, weigh them accurately, add 75% methanol to prepare each 1mL containing 0.3 μg of acteoside, 20 μg of procuroside, and 5-O-methylvesamicin Alcohol glycoside 1μg, apigenin-7-O-glucoside 2μg, hydrated oxidized proscurdin 1μg, ligustonin A 0.4μg, caffeine 20μg, paeoniflorin 40μg, rosmarinic acid 1μg, liquiritin 0.3μg, Mixed reference substance of lisenside E 2 μg, liquiritin 2 μg, isoliquiritin 0.3 μg, luteolin 2 μg, oxidized paeoniflorin 2 μg, isochlorogenic acid B 3 μg, isochlorogenic acid A 2 μg, isochlorogenic acid C 2 μg Solution, that is.

[0052] (2) Preparation of the test solution: Accurately measure 1mL of this product, put it in a 25mL measuring bottle, add 75% methanol to dilute to the mark,...

Embodiment 2

[0070] The present embodiment provides a method for determining the content of multi-index components in Tongtian Oral Liquid, which includes the following steps:

[0071] (1) Preparation of reference substance solution: same as in Example 1.

[0072] (2) Preparation of test solution: same as in Example 1.

[0073] (3) Preparation of mobile phase: with embodiment 1.

[0074] (4) Setting of chromatographic conditions: flow rate: 0.2mL / min; other conditions are the same as in Example 1.

[0075] (5) Setting of QDa condition: same as embodiment 1.

[0076] (6) Determination of samples: 1 μL of each of the reference substance solution and the test solution were precisely drawn, injected into the liquid chromatograph, and measured. In Tongtian Oral Liquid (batch number: 19090040), each ml contains Chuanxiong Ligusticum Ligusticum Lactone A (C 12 h 16 o 2 ) in terms of 0.02mg; containing notopterygium and angelica dahurica and procuroside (C 20 h 24 o 9 ) and hydrated oxidi...

Embodiment 3

[0078] The present embodiment provides a method for determining the content of multi-index components in Tongtian Oral Liquid, which includes the following steps:

[0079] (1) Preparation of reference substance solution: same as in Example 1.

[0080] (2) Preparation of test solution: same as in Example 1.

[0081] (3) Preparation of mobile phase: with embodiment 1.

[0082] (4) Setting of chromatographic conditions: flow rate: 0.5mL / min; other conditions are the same as in Example 1.

[0083] (5) Setting of QDa condition: same as embodiment 1.

[0084] (6) Determination of samples: 1 μL of each of the reference substance solution and the test solution were precisely drawn, injected into the liquid chromatograph, and measured. In Tongtian Oral Liquid (batch number: 19090040), each ml contains Chuanxiong Ligusticum Ligusticum Lactone A (C 12 h 16 o 2 ) in terms of 0.02mg; containing notopterygium and angelica dahurica and procuroside (C 20 h 24 o 9 ) and hydrated oxidi...

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Abstract

The invention provides a method for determining contents of multi-index components in Tongtian oral liquid, which comprises the following steps of using an ultra-high performance liquid chromatography-tandem QDa detector; simultaneously determining the contents of 18 components in the Tongtian oral liquid: cimicifugin, decurin, 5-O-methylvisammioside, apigenin-7-O-glucoside, hydrated oxidized peucedanin, senkyunolide A, caffeine, paeoniflorin, rosmarinic acid, liquiritigenin, parishin E, liquiritin, isoliquiritin, galuteolin, oxidized paeoniflorin, isochlorogenic acid B, isochlorogenic acid A, and isochlorogenic acid C. The method is easy to operate, rapid, efficient, accurate and reliable, the stability of the production process can be effectively monitored, and a guarantee is provided for the quality of the Tongtian oral liquid.

Description

technical field [0001] The invention relates to the technical field of content determination of traditional Chinese medicine components, in particular to a method for determining the content of multi-index components in Tongtian Oral Liquid. Background technique [0002] Tongtian Oral Liquid is based on the classic traditional Chinese medicine "Chuanxiong Tea Tiaosan". It is composed of 11 medicinal materials such as Chuanxiong, Chishao, Tianma, Notopterygium, Angelica, Asarum, Chrysanthemum, Mint, Fangfeng, Tea, and Licorice. The effect of dispelling blood stasis, expelling wind and relieving pain is mainly used clinically for the treatment of migraine caused by stagnation of blood stagnation and disturbance of pathogenic wind. In the prescription, Chuanxiong promotes blood circulation and removes blood stasis, promotes qi and relieves depression, dispels wind and relieves pain as the monarch drug; notopterygium, angelica dahurica, and Gastrodia elata are combined to reliev...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/72
CPCG01N30/02G01N30/06G01N30/72
Inventor 周丹丹崔雨晴沙禕炜米卓尔陈方超吴清云
Owner 鉴甄检测技术(上海)有限公司
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